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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for PTGS2 |
Basic gene info. | Gene symbol | PTGS2 |
Gene name | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | |
Synonyms | COX-2|COX2|GRIPGHS|PGG/HS|PGHS-2|PHS-2|hCox-2 | |
Cytomap | UCSC genome browser: 1q25.2-q25.3 | |
Genomic location | chr1 :186640943-186649559 | |
Type of gene | protein-coding | |
RefGenes | NM_000963.3, | |
Ensembl id | ENSG00000073756 | |
Description | PGH synthase 2PHS IIcyclooxygenase 2bprostaglandin G/H synthase 2prostaglandin H2 synthase 2 | |
Modification date | 20141222 | |
dbXrefs | MIM : 600262 | |
HGNC : HGNC | ||
Ensembl : ENSG00000073756 | ||
HPRD : 02599 | ||
Vega : OTTHUMG00000035473 | ||
Protein | UniProt: P35354 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PTGS2 | |
BioGPS: 5743 | ||
Gene Expression Atlas: ENSG00000073756 | ||
The Human Protein Atlas: ENSG00000073756 | ||
Pathway | NCI Pathway Interaction Database: PTGS2 | |
KEGG: PTGS2 | ||
REACTOME: PTGS2 | ||
ConsensusPathDB | ||
Pathway Commons: PTGS2 | ||
Metabolism | MetaCyc: PTGS2 | |
HUMANCyc: PTGS2 | ||
Regulation | Ensembl's Regulation: ENSG00000073756 | |
miRBase: chr1 :186,640,943-186,649,559 | ||
TargetScan: NM_000963 | ||
cisRED: ENSG00000073756 | ||
Context | iHOP: PTGS2 | |
cancer metabolism search in PubMed: PTGS2 | ||
UCL Cancer Institute: PTGS2 | ||
Assigned class in ccmGDB | A - This gene has a literature evidence and it belongs to cancer gene. | |
References showing role of PTGS2 in cancer cell metabolism | 1. Habermann N, Ulrich CM, Lundgreen A, Makar KW, Poole EM, et al. (2013) PTGS1, PTGS2, ALOX5, ALOX12, ALOX15, and FLAP SNPs: interaction with fatty acids in colon cancer and rectal cancer. Genes & nutrition 8: 115-126. go to article |
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Phenotypic Information for PTGS2(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: PTGS2 |
Familial Cancer Database: PTGS2 |
* This gene is included in those cancer gene databases. |
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
KEGG_ARACHIDONIC_ACID_METABOLISM |
Others | |
OMIM | 600262; gene. |
Orphanet | |
Disease | KEGG Disease: PTGS2 |
MedGen: PTGS2 (Human Medical Genetics with Condition) | |
ClinVar: PTGS2 | |
Phenotype | MGI: PTGS2 (International Mouse Phenotyping Consortium) |
PhenomicDB: PTGS2 |
Mutations for PTGS2 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
There's no structural variation information in COSMIC data for this gene. |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows PTGS2 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
There's no copy number variation information in COSMIC data for this gene. |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=75) | (# total SNVs=17) |
(# total SNVs=1) | (# total SNVs=0) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr1:186643865-186643865 | p.A479S | 3 |
chr1:186645692-186645692 | p.R293W | 2 |
chr1:186643501-186643501 | p.R600H | 2 |
chr1:186648497-186648497 | p.C42C | 2 |
chr1:186645242-186645242 | p.P349T | 2 |
chr1:186648237-186648237 | p.N89S | 2 |
chr1:186644514-186644514 | p.R424S | 2 |
chr1:186643631-186643631 | p.N557D | 2 |
chr1:186645642-186645642 | p.W309* | 2 |
chr1:186648219-186648219 | p.R95Q | 2 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 1 | 3 |   | 11 |   |   | 2 |   | 4 |   |   | 8 | 2 | 2 |   |   | 10 | 5 |   | 10 |
# mutation | 1 | 3 |   | 11 |   |   | 2 |   | 4 |   |   | 10 | 2 | 2 |   |   | 11 | 5 |   | 12 |
nonsynonymous SNV | 1 | 2 |   | 8 |   |   | 1 |   | 3 |   |   | 8 | 1 | 1 |   |   | 10 | 4 |   | 10 |
synonymous SNV |   | 1 |   | 3 |   |   | 1 |   | 1 |   |   | 2 | 1 | 1 |   |   | 1 | 1 |   | 2 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr1:186643808 | p.C42C | 2 |
chr1:186648497 | p.R293L | 2 |
chr1:186645691 | p.R293W | 2 |
chr1:186645692 | p.P498S | 2 |
chr1:186645267 | p.R585H | 1 |
chr1:186648486 | p.P427P | 1 |
chr1:186643546 | p.P249S | 1 |
chr1:186645824 | p.M99I | 1 |
chr1:186643805 | p.S583Y | 1 |
chr1:186646898 | p.E410K | 1 |
Other DBs for Point Mutations |
Copy Number for PTGS2 in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for PTGS2 |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
ACTR3B,ADH4,ARID5A,C6orf15,CCND2,DGKI,HOXA11, HOXA11-AS,IRX1,NRG1,OR2T1,PDC,PLA2G4A,PTGS2, QRICH2,SPHK1,SYN3,TAC4,TFAP2D,TMEM132E,TMEM14E | ATF3,B3GNT5,BTG2,CXCL2,CYR61,DUSP1,DUSP5, EGR1,EGR2,FOS,FOSB,IL1B,MAP3K8,NCOA7, NFKBIZ,NR4A2,PTGS2,RGS16,TRIB1,ZFP36,ZFP36L1 | ||||
A2ML1,ACTBL2,ARHGAP29,C8orf86,CAV2,CP,CST6, DAPK1,F3,IGFBP3,IL1RAPL1,ITGA3,LIPK,LOC285830, NKX3-1,PODXL,PRAMEF6,PSG6,PSG9,PTGES,PTGS2 | ATP6V0E2,CCDC160,CCL3,CH25H,EGR1,EGR2,IL9, INTU,KLF11,KLHL20,LOC221710,MSLNL,NALCN,PAGE2, PTGS2,RNU4ATAC,SIK1,SNORA9,TNF,UBE2G2,ZSCAN12P1 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for PTGS2 |
Cross-referenced pharmacological DB IDs from Uniprot |
DB Category | DB Name | DB's ID and Url link |
Chemistry | BindingDB | P35354; -. |
Chemistry | ChEMBL | CHEMBL2094253; -. |
Chemistry | GuidetoPHARMACOLOGY | 1376; -. |
Organism-specific databases | PharmGKB | PA293; -. |
Organism-specific databases | CTD | 5743; -. |
Drug-Gene Interaction Network |
* Gene Centered Interaction Network. |
* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB00154 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved; nutraceutical | gamma-Homolinolenic acid | ||
DB00159 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved; nutraceutical | Icosapent | ||
DB00233 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved | Aminosalicylic Acid | ||
DB00244 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved | Mesalazine | ||
DB00316 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved | Acetaminophen | ||
DB00328 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved; investigational | Indomethacin | ||
DB00461 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved | Nabumetone | ||
DB00465 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved | Ketorolac | ||
DB00469 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved | Tenoxicam | ||
DB00480 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved; investigational | Lenalidomide | ||
DB00482 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved; investigational | Celecoxib | ||
DB00500 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved | Tolmetin | ||
DB00533 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | withdrawn; investigational | Rofecoxib | ||
DB00554 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved; investigational | Piroxicam | ||
DB00573 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved | Fenoprofen | ||
DB00580 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | withdrawn; investigational | Valdecoxib | ||
DB00586 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved | Diclofenac | ||
DB00605 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved | Sulindac | ||
DB00712 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved | Flurbiprofen | ||
DB00749 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved; investigational | Etodolac | ||
DB00784 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved | Mefenamic acid | ||
DB00788 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved | Naproxen | ||
DB00795 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved | Sulfasalazine | ||
DB00812 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved | Phenylbutazone | ||
DB00814 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved | Meloxicam | ||
DB00821 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved | Carprofen | ||
DB00861 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved | Diflunisal | ||
DB00870 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved | Suprofen | ||
DB00936 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved | Salicyclic acid | ||
DB00939 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved | Meclofenamic acid | ||
DB00945 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved | Acetylsalicylic acid | ||
DB00963 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved | Bromfenac | ||
DB00991 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved | Oxaprozin | ||
DB01009 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved | Ketoprofen | ||
DB01014 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved; investigational | Balsalazide | ||
DB01041 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved; withdrawn; investigational | Thalidomide | ||
DB01050 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved | Ibuprofen | ||
DB01283 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved; investigational | Lumiracoxib | ||
DB01294 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved | Bismuth Subsalicylate | ||
DB01397 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved | Magnesium salicylate | ||
DB01398 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved | Salicylate-sodium | ||
DB01399 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved | Salsalate | ||
DB01401 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved | Trisalicylate-choline | ||
DB01419 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved | Antrafenine | ||
DB01435 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved | Antipyrine | ||
DB01600 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved | Tiaprofenic acid | ||
DB01628 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved; investigational | Etoricoxib | ||
DB02266 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | experimental | Flufenamic Acid | ||
DB02709 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | experimental; investigational | Resveratrol | ||
DB03014 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | experimental | Heme | ||
DB03477 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | experimental | 1-Phenylsulfonamide-3-Trifluoromethyl-5-Parabromophenylpyrazole | ||
DB03866 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | experimental | Prostaglandin G2 | ||
DB04552 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved | Niflumic Acid | ||
DB04743 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | experimental | Nimesulide | ||
DB06725 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved | Lornoxicam | ||
DB06802 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved | Nepafenac | ||
DB00317 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved; investigational | Gefitinib | ||
DB01234 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved; investigational | Dexamethasone | ||
DB00864 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved; investigational | Tacrolimus | ||
DB01242 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved | Clomipramine | ||
DB01101 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved; investigational | Capecitabine | ||
DB00526 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | approved; investigational | Oxaliplatin |
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Cross referenced IDs for PTGS2 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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