Cancer Cell Metabolism Gene Database

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for PTGS2
Basic gene info.Gene symbolPTGS2
Gene nameprostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
SynonymsCOX-2|COX2|GRIPGHS|PGG/HS|PGHS-2|PHS-2|hCox-2
CytomapUCSC genome browser: 1q25.2-q25.3
Genomic locationchr1 :186640943-186649559
Type of geneprotein-coding
RefGenesNM_000963.3,
Ensembl idENSG00000073756
DescriptionPGH synthase 2PHS IIcyclooxygenase 2bprostaglandin G/H synthase 2prostaglandin H2 synthase 2
Modification date20141222
dbXrefs MIM : 600262
HGNC : HGNC
Ensembl : ENSG00000073756
HPRD : 02599
Vega : OTTHUMG00000035473
ProteinUniProt: P35354
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PTGS2
BioGPS: 5743
Gene Expression Atlas: ENSG00000073756
The Human Protein Atlas: ENSG00000073756
PathwayNCI Pathway Interaction Database: PTGS2
KEGG: PTGS2
REACTOME: PTGS2
ConsensusPathDB
Pathway Commons: PTGS2
MetabolismMetaCyc: PTGS2
HUMANCyc: PTGS2
RegulationEnsembl's Regulation: ENSG00000073756
miRBase: chr1 :186,640,943-186,649,559
TargetScan: NM_000963
cisRED: ENSG00000073756
ContextiHOP: PTGS2
cancer metabolism search in PubMed: PTGS2
UCL Cancer Institute: PTGS2
Assigned class in ccmGDBA - This gene has a literature evidence and it belongs to cancer gene.
References showing role of PTGS2 in cancer cell metabolism1. Habermann N, Ulrich CM, Lundgreen A, Makar KW, Poole EM, et al. (2013) PTGS1, PTGS2, ALOX5, ALOX12, ALOX15, and FLAP SNPs: interaction with fatty acids in colon cancer and rectal cancer. Genes & nutrition 8: 115-126. go to article

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Phenotypic Information for PTGS2(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: PTGS2
Familial Cancer Database: PTGS2
* This gene is included in those cancer gene databases.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_ARACHIDONIC_ACID_METABOLISM

check002.gifOthers
OMIM 600262; gene.
Orphanet
DiseaseKEGG Disease: PTGS2
MedGen: PTGS2 (Human Medical Genetics with Condition)
ClinVar: PTGS2
PhenotypeMGI: PTGS2 (International Mouse Phenotyping Consortium)
PhenomicDB: PTGS2

Mutations for PTGS2
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows PTGS2 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=4

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=75)
Stat. for Synonymous SNVs
(# total SNVs=17)
Stat. for Deletions
(# total SNVs=1)
Stat. for Insertions
(# total SNVs=0)
There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr1:186643865-186643865p.A479S3
chr1:186643631-186643631p.N557D2
chr1:186645642-186645642p.W309*2
chr1:186648219-186648219p.R95Q2
chr1:186645968-186645968p.Y240*2
chr1:186645691-186645691p.R293Q2
chr1:186643498-186643498p.S601*2
chr1:186645692-186645692p.R293W2
chr1:186643501-186643501p.R600H2
chr1:186645242-186645242p.P349T2

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=4

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample13 11  2 4  822  105 10
# mutation13 11  2 4  1022  115 12
nonsynonymous SNV12 8  1 3  811  104 10
synonymous SNV 1 3  1 1  211  11 2
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr1:186645691p.C42C2
chr1:186645692p.R293L2
chr1:186643808p.R293W2
chr1:186648497p.P498S2
chr1:186646005p.G340G1
chr1:186643623p.H212N1
chr1:186646956p.R46L1
chr1:186644398p.I544I1
chr1:186645624p.H337Y1
chr1:186648534p.N208N1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for PTGS2 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for PTGS2

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ACTR3B,ADH4,ARID5A,C6orf15,CCND2,DGKI,HOXA11,
HOXA11-AS,IRX1,NRG1,OR2T1,PDC,PLA2G4A,PTGS2,
QRICH2,SPHK1,SYN3,TAC4,TFAP2D,TMEM132E,TMEM14E
ATF3,B3GNT5,BTG2,CXCL2,CYR61,DUSP1,DUSP5,
EGR1,EGR2,FOS,FOSB,IL1B,MAP3K8,NCOA7,
NFKBIZ,NR4A2,PTGS2,RGS16,TRIB1,ZFP36,ZFP36L1

A2ML1,ACTBL2,ARHGAP29,C8orf86,CAV2,CP,CST6,
DAPK1,F3,IGFBP3,IL1RAPL1,ITGA3,LIPK,LOC285830,
NKX3-1,PODXL,PRAMEF6,PSG6,PSG9,PTGES,PTGS2
ATP6V0E2,CCDC160,CCL3,CH25H,EGR1,EGR2,IL9,
INTU,KLF11,KLHL20,LOC221710,MSLNL,NALCN,PAGE2,
PTGS2,RNU4ATAC,SIK1,SNORA9,TNF,UBE2G2,ZSCAN12P1
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for PTGS2
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link
ChemistryBindingDB P35354; -.
ChemistryChEMBL CHEMBL2094253; -.
ChemistryGuidetoPHARMACOLOGY 1376; -.
Organism-specific databasesPharmGKB PA293; -.
Organism-specific databasesCTD 5743; -.

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB00154prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approved; nutraceuticalgamma-Homolinolenic acid
DB00159prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approved; nutraceuticalIcosapent
DB00233prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approvedAminosalicylic Acid
DB00244prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approvedMesalazine
DB00316prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approvedAcetaminophen
DB00328prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approved; investigationalIndomethacin
DB00461prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approvedNabumetone
DB00465prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approvedKetorolac
DB00469prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approvedTenoxicam
DB00480prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approved; investigationalLenalidomide
DB00482prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approved; investigationalCelecoxib
DB00500prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approvedTolmetin
DB00533prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)withdrawn; investigationalRofecoxib
DB00554prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approved; investigationalPiroxicam
DB00573prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approvedFenoprofen
DB00580prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)withdrawn; investigationalValdecoxib
DB00586prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approvedDiclofenac
DB00605prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approvedSulindac
DB00712prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approvedFlurbiprofen
DB00749prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approved; investigationalEtodolac
DB00784prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approvedMefenamic acid
DB00788prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approvedNaproxen
DB00795prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approvedSulfasalazine
DB00812prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approvedPhenylbutazone
DB00814prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approvedMeloxicam
DB00821prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approvedCarprofen
DB00861prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approvedDiflunisal
DB00870prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approvedSuprofen
DB00936prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approvedSalicyclic acid
DB00939prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approvedMeclofenamic acid
DB00945prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approvedAcetylsalicylic acid
DB00963prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approvedBromfenac
DB00991prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approvedOxaprozin
DB01009prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approvedKetoprofen
DB01014prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approved; investigationalBalsalazide
DB01041prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approved; withdrawn; investigationalThalidomide
DB01050prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approvedIbuprofen
DB01283prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approved; investigationalLumiracoxib
DB01294prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approvedBismuth Subsalicylate
DB01397prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approvedMagnesium salicylate
DB01398prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approvedSalicylate-sodium
DB01399prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approvedSalsalate
DB01401prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approvedTrisalicylate-choline
DB01419prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approvedAntrafenine
DB01435prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approvedAntipyrine
DB01600prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approvedTiaprofenic acid
DB01628prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approved; investigationalEtoricoxib
DB02266prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)experimentalFlufenamic Acid
DB02709prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)experimental; investigationalResveratrol
DB03014prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)experimentalHeme
DB03477prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)experimental1-Phenylsulfonamide-3-Trifluoromethyl-5-Parabromophenylpyrazole
DB03866prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)experimentalProstaglandin G2
DB04552prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approvedNiflumic Acid
DB04743prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)experimentalNimesulide
DB06725prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approvedLornoxicam
DB06802prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approvedNepafenac
DB00317prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approved; investigationalGefitinib
DB01234prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approved; investigationalDexamethasone
DB00864prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approved; investigationalTacrolimus
DB01242prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approvedClomipramine
DB01101prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approved; investigationalCapecitabine
DB00526prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)approved; investigationalOxaliplatin


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Cross referenced IDs for PTGS2
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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