Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for G6PC2
Basic gene info.Gene symbolG6PC2
Gene nameglucose-6-phosphatase, catalytic, 2
SynonymsIGRP
CytomapUCSC genome browser: 2q24.3
Genomic locationchr2 :169757749-169766510
Type of geneprotein-coding
RefGenesNM_001081686.1,
NM_021176.2,
Ensembl idENSG00000262563
DescriptionG-6-Pase 2G6Pase 2glucose-6-phosphatase 2islet-specific G6CP-related proteinislet-specific glucose-6-phosphatase catalytic subunit-related proteinislet-specific glucose-6-phosphatase-related protein
Modification date20141207
dbXrefs MIM : 608058
HGNC : HGNC
HPRD : 16272
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_G6PC2
BioGPS: 57818
Gene Expression Atlas: ENSG00000262563
The Human Protein Atlas: ENSG00000262563
PathwayNCI Pathway Interaction Database: G6PC2
KEGG: G6PC2
REACTOME: G6PC2
ConsensusPathDB
Pathway Commons: G6PC2
MetabolismMetaCyc: G6PC2
HUMANCyc: G6PC2
RegulationEnsembl's Regulation: ENSG00000262563
miRBase: chr2 :169,757,749-169,766,510
TargetScan: NM_001081686
cisRED: ENSG00000262563
ContextiHOP: G6PC2
cancer metabolism search in PubMed: G6PC2
UCL Cancer Institute: G6PC2
Assigned class in ccmGDBC

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Phenotypic Information for G6PC2(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: G6PC2
Familial Cancer Database: G6PC2
* This gene is included in those cancer gene databases.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_GLYCOLYSIS_GLUCONEOGENESIS
KEGG_GALACTOSE_METABOLISM
KEGG_STARCH_AND_SUCROSE_METABOLISM
REACTOME_METABOLISM_OF_CARBOHYDRATES

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: G6PC2
MedGen: G6PC2 (Human Medical Genetics with Condition)
ClinVar: G6PC2
PhenotypeMGI: G6PC2 (International Mouse Phenotyping Consortium)
PhenomicDB: G6PC2

Mutations for G6PC2
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows G6PC2 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=5

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=41)
Stat. for Synonymous SNVs
(# total SNVs=5)
Stat. for Deletions
(# total SNVs=0)
Stat. for Insertions
(# total SNVs=0)
There's no deleted snv.There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr2:169764546-169764546p.S342C5
chr2:169764176-169764176p.V219L3
chr2:169764282-169764282p.T254M3
chr2:169763180-169763180p.T149T1
chr2:169764539-169764539p.P340S1
chr2:169757922-169757922p.N27K1
chr2:169764111-169764111p.P197R1
chr2:169758968-169758968p.H78N1
chr2:169764377-169764377p.N286D1
chr2:169763190-169763190p.L153I1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=1

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample 2 3  3    631  42 10
# mutation 2 3  3    631  42 12
nonsynonymous SNV 2 3  3    431  31 11
synonymous SNV           2    11 1
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr2:169764237p.N27K,G6PC21
chr2:169757925p.C165R1
chr2:169764517p.F325I1
chr2:169761069p.F28L,G6PC21
chr2:169764244p.V179A1
chr2:169757948p.P332P1
chr2:169764518p.R36M,G6PC21
chr2:169763190p.G182E1
chr2:169764282p.L333L1
chr2:169757987p.F49C,G6PC21

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for G6PC2 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for G6PC2

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ADAM7,CGB,CGB1,CGB5,DHRS7B,FOXD4L2,G6PC2,
GCG,GSTTP1,INS,LOC727924,MUC20,OLIG3,OR4N3P,
PWAR4___F2RL3___PAWR,PPY,SNORD115-26,TBX10,TEX28,TTR,USP22
AOX2P,PP2D1,CGB2,EP400NL,FLJ10213,G6PC2,GRM8,
HELT,HPVC1,IAPP,LOC283922,LOC91948,LRGUK,NRSN1,
OR10H1,OR10J5,OR5P2,PCDHGB2,PRDM7,SLC6A19,USH2A

ASRGL1,ATOH1,ATP2A3,ATP8A1,LINC00469,CD5L,FAM167A,
FAM174B,FOXD4L1,G6PC2,GPR20,HRK,IMPA2,INSL4,
KLK11,MAGEA1,PTGER2,RASD2,ST6GALNAC1,SYTL1,TOX
BSND,SMCO2,C5orf58,SAPCD1,CLCNKB,COL9A2,EPGN,
FANK1,G6PC2,GNRH1,KIAA1468,LOC100240734,MDM2,NEUROD2,
PMS2,PRR25,SNHG12,TBC1D26,TDRD5,UCN2,ZNF100
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for G6PC2


There's no related Drug.
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Cross referenced IDs for G6PC2
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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