Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

Home

	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for LSM2

Basic gene info.	Gene symbol	LSM2
	Gene name	LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
	Synonyms	C6orf28\|G7B\|YBL026W\|snRNP
	Cytomap	UCSC genome browser: 6p21.3
	Genomic location	chr6_mcf_hap5 :3144865-3154459
	Type of gene	protein-coding
	RefGenes	NM_021177.4,
	Ensembl id	ENSG00000204392
	Description	U6 snRNA-associated Sm-like protein LSm2protein G7bsmall nuclear ribonuclear protein D homologsnRNP core Sm-like protein Sm-x5
	Modification date	20141207
dbXrefs	MIM : 607282
	HGNC : HGNC
	Ensembl : ENSG00000204392
	HPRD : 06282
	Vega : OTTHUMG00000031121
Protein	UniProt: Q9Y333 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_LSM2
	BioGPS: 57819
	Gene Expression Atlas: ENSG00000204392
	The Human Protein Atlas: ENSG00000204392
Pathway	NCI Pathway Interaction Database: LSM2
	KEGG: LSM2
	REACTOME: LSM2
	ConsensusPathDB
	Pathway Commons: LSM2
Metabolism	MetaCyc: LSM2
	HUMANCyc: LSM2
Regulation	Ensembl's Regulation: ENSG00000204392
	miRBase: chr6_mcf_hap5 :3,144,865-3,154,459
	TargetScan: NM_021177
	cisRED: ENSG00000204392
Context	iHOP: LSM2
	cancer metabolism search in PubMed: LSM2
	UCL Cancer Institute: LSM2
Assigned class in ccmGDB	B - This gene belongs to cancer gene.

Top

Phenotypic Information for LSM2(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: LSM2
	Familial Cancer Database: LSM2

* This gene is included in those cancer gene databases.

						.
Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in	Therapeutic Vulnerabilities in Cancer¹

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
REACTOME_METABOLISM_OF_MRNA REACTOME_METABOLISM_OF_RNA

Others
OMIM	607282; gene.
Orphanet
Disease	KEGG Disease: LSM2
	MedGen: LSM2 (Human Medical Genetics with Condition)
	ClinVar: LSM2
Phenotype	MGI: LSM2 (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: LSM2

Mutations for LSM2

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

There's no structural variation information in COSMIC data for this gene.

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows LSM2 related fusion information.

Head Gene

Tail Gene

Accession

Gene_a

qStart_a

qEnd_a

Chromosome_a

tStart_a

tEnd_a

Gene_a

qStart_a

qEnd_a

Chromosome_a

tStart_a

tEnd_a

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

Top

Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

There's no copy number variation information in COSMIC data for this gene.

Top

SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=3

Top

Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=8)	Stat. for Synonymous SNVs (# total SNVs=3)

Stat. for Deletions (# total SNVs=0)	Stat. for Insertions (# total SNVs=0)
There's no deleted snv.	There's no inserted snv.

Top

Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr6:31765563-31765563	p.R87G	3
chr6:31765567-31765567	p.A85A	2
chr6:31765565-31765565	p.A86V	2
chr6:31765628-31765628	p.S65L	1
chr6:31765635-31765635	p.R63W	1
chr6:31765646-31765646	p.N59S	1
chr6:31766264-31766264	p.S31F	1
chr6:31773857-31773857	p.D22D	1
chr6:31773919-31773919	p.L2V	1
chr6:31773924-31773924	p.?	1

Top

SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=1

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample	1			1			1					1					1
# mutation	1			1			1					1					1
nonsynonymous SNV	1			1			1										1
synonymous SNV												1

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

Top

Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chr6:31765774	p.S31F	1
chr6:31766264	p.L2V	1
chr6:31773919	p.Y69Y	1
chr6:31765615	p.S56L	1
chr6:31765655	p.P52H	1

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for LSM2 in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

Top

Gene Expression for LSM2

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

Top

CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

Top

Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


ABCF1,ABT1,CCDC167,CSNK2B,FKBPL,GTF2H4,HMGA1, LSM2,NDUFAF4,NPM3,NUDT3,NELFE,RPP21,SNRPC, SNRPD1,SNRPG,TAF11,TUBB,UQCRH,WDR46,ZNRD1	C17orf49,CSNK2B,CUTA,DGUOK,DPM2,DYRK4,LSM2, PDCD6,PFDN5,POLR2G,PPIA,PPIH,RPL27A,RPS24, SF3B14,SNRPD2,SNRPF,SSR2,SUPT4H1,UBE2I,UXT

CKS2,COX7A2,GADD45GIP1,LSM2,LSM3,MRPL11,MRPL14, MRPL22,MRPL54,MYEOV2,NDUFA11,NDUFA13,PPIL1,RPL35, RPS10,RPS18,SF3B5,SRSF3,SNRPC,SNRPG,TIMM8B	ADSL,ELP6,TMEM261,GEMIN6,LSM2,MRPL11,MRPL49, MRPL52,MRPS14,MRPS15,MRPS7,NHP2,NUDCD2,POLE3, POLR2G,RPL35,RPSAP58,SNRPC,SNRPD2,STOML2,TOMM6

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

Top

Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

Top

Pharmacological Information for LSM2

Cross-referenced pharmacological DB IDs from Uniprot

DB Category	DB Name	DB's ID and Url link
Organism-specific databases	PharmGKB	PA25929; -.
Organism-specific databases	CTD	57819; -.

Drug-Gene Interaction Network

* Gene Centered Interaction Network.

* Drug Centered Interaction Network.

DrugBank ID	Target Name	Drug Groups	Generic Name	Drug Centered Network	Drug Structure
DB00564	LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)	approved; investigational	Carbamazepine

Top

Cross referenced IDs for LSM2

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information