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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for RENBP |
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Phenotypic Information for RENBP(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: RENBP |
Familial Cancer Database: RENBP |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM |
Others | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: RENBP |
MedGen: RENBP (Human Medical Genetics with Condition) | |
ClinVar: RENBP | |
Phenotype | MGI: RENBP (International Mouse Phenotyping Consortium) |
PhenomicDB: RENBP |
Mutations for RENBP |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
There's no structural variation information in COSMIC data for this gene. |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows RENBP related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
BF799253 | RENBP | 170 | 191 | X | 153205691 | 153205712 | RAD23A | 180 | 371 | 19 | 13059069 | 13059528 |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
There's no copy number variation information in COSMIC data for this gene. |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=26) | (# total SNVs=10) |
(# total SNVs=2) | (# total SNVs=0) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr23:153206997-153206997 | p.S283S | 2 |
chr23:153201002-153201002 | p.F359I | 1 |
chr23:153209078-153209078 | p.Q118* | 1 |
chr23:153206986-153206986 | p.P287H | 1 |
chr23:153209596-153209596 | p.T40M | 1 |
chr23:153208402-153208402 | p.L188M | 1 |
chr23:153205581-153205581 | p.Q341K | 1 |
chr23:153209094-153209094 | p.G112G | 1 |
chr23:153209604-153209604 | p.G37G | 1 |
chr23:153208406-153208406 | p.L186L | 1 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 2 | 1 |   | 4 | 1 |   | 2 |   | 2 |   |   | 3 | 3 | 1 |   |   | 3 | 2 | 1 | 7 |
# mutation | 3 | 1 |   | 4 | 1 |   | 2 |   | 2 |   |   | 3 | 3 | 1 |   |   | 4 | 2 | 1 | 7 |
nonsynonymous SNV | 2 |   |   | 3 | 1 |   | 2 |   | 2 |   |   | 3 | 2 | 1 |   |   | 3 | 1 | 1 | 5 |
synonymous SNV | 1 | 1 |   | 1 |   |   |   |   |   |   |   |   | 1 |   |   |   | 1 | 1 |   | 2 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chrX:153205581 | p.Q351K | 1 |
chrX:153209857 | p.I164I | 1 |
chrX:153207102 | p.E14A | 1 |
chrX:153209166 | p.L348P | 1 |
chrX:153205589 | p.E159A | 1 |
chrX:153207421 | p.R347H | 1 |
chrX:153209359 | p.F136L | 1 |
chrX:153205592 | p.M335T | 1 |
chrX:153207423 | p.G122G | 1 |
chrX:153209401 | p.L334L | 1 |
Other DBs for Point Mutations |
Copy Number for RENBP in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for RENBP |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
ANGPTL6,SOWAHD,APOE,BRI3,FUOM,THEMIS2,C1QA, C1QB,CYBA,DOK2,FERMT3,GPX1,IFI30,NCF4, RENBP,RHOG,SPI1,IGFLR1,TNFRSF4,TYMP,TYROBP | C1QA,TOR4A,CD68,CTSL,CTSZ,DOK2,FCGRT, FOLR2,FTL,COLGALT1,IFFO1,LOXL3,NRROS,MCOLN1, MGAT1,MPP1,NCF4,RENBP,SPI1,TCN2,TRPV2 | ||||
ACP5,ADPRH,C1orf85,CECR1,CPVL,CTSH,CTSZ, CYB5R1,FGD3,GBGT1,HSD17B14,KCNAB2,KLHDC8B,NPL, PLA1A,RENBP,SCPEP1,SLC47A1,TFE3,TMEM86A,TPP1 | ARRB2,C1QA,C1QB,C1QC,C2,C3AR1,CD33, CMKLR1,CSF1R,GGTA1P,HK3,HSD17B14,LAIR1,LRRC25, MAFB,PILRA,RASGRP4,RENBP,SCPEP1,SIGLEC1,SLC24A4 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for RENBP |
Cross-referenced pharmacological DB IDs from Uniprot |
DB Category | DB Name | DB's ID and Url link |
Drug-Gene Interaction Network |
* Gene Centered Interaction Network. |
* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB00141 | renin binding protein | approved; nutraceutical | N-Acetyl-D-glucosamine |
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Cross referenced IDs for RENBP |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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