Cancer Cell Metabolism Gene Database

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for ELOVL5
Basic gene info.Gene symbolELOVL5
Gene nameELOVL fatty acid elongase 5
SynonymsHELO1|SCA38|dJ483K16.1
CytomapUCSC genome browser: 6p21.1-p12.1
Genomic locationchr6 :53132195-53213977
Type of geneprotein-coding
RefGenesNM_001242828.1,
NM_001242830.1,NM_001242831.1,NM_001301856.1,NM_021814.4,
Ensembl idENSG00000012660
Description3-keto acyl-CoA synthase ELOVL5ELOVL FA elongase 5ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)elongation of very long chain fatty acids protein 5fatty acid elongase 1homolog of yeast long chain polyun
Modification date20141212
dbXrefs MIM : 611805
HGNC : HGNC
Ensembl : ENSG00000012660
HPRD : 13268
Vega : OTTHUMG00000016249
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ELOVL5
BioGPS: 60481
Gene Expression Atlas: ENSG00000012660
The Human Protein Atlas: ENSG00000012660
PathwayNCI Pathway Interaction Database: ELOVL5
KEGG: ELOVL5
REACTOME: ELOVL5
ConsensusPathDB
Pathway Commons: ELOVL5
MetabolismMetaCyc: ELOVL5
HUMANCyc: ELOVL5
RegulationEnsembl's Regulation: ENSG00000012660
miRBase: chr6 :53,132,195-53,213,977
TargetScan: NM_001242828
cisRED: ENSG00000012660
ContextiHOP: ELOVL5
cancer metabolism search in PubMed: ELOVL5
UCL Cancer Institute: ELOVL5
Assigned class in ccmGDBC

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Phenotypic Information for ELOVL5(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: ELOVL5
Familial Cancer Database: ELOVL5
* This gene is included in those cancer gene databases.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: ELOVL5
MedGen: ELOVL5 (Human Medical Genetics with Condition)
ClinVar: ELOVL5
PhenotypeMGI: ELOVL5 (International Mouse Phenotyping Consortium)
PhenomicDB: ELOVL5

Mutations for ELOVL5
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram

- Statistics for Tissue and Mutation typeTop
- For Inter-chromosomal Variations
There's no inter-chromosomal structural variation.
- For Intra-chromosomal Variations
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'.
SampleSymbol_aChr_aStart_aEnd_aSymbol_bChr_bStart_bEnd_b
ovaryELOVL5chr65314552253145542ELOVL5chr65315885853158878
pancreasELOVL5chr65315061353150633chr612132841213304
pancreasELOVL5chr65316937053169390chr65306565753065677
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract)

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ELOVL5 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
DB155046MTERF133279150348391503814ELOVL533258965315667553213719
AV686607USF11911161013096161014737ELOVL58433165313257253132882
BM827569CYBA26304168871255688714522ELOVL529958965315658353213660
BE929601ELOVL5413865313303653133172SGIP113915816717515367175172
BF096087DDX520249176249905062499369ELOVL524854965313807653141039
BE929559ELOVL52015665313303353133172SGIP115717616717515367175172

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
 
Mutation type/ Tissue IDbrcacnscervendomehaematopokidnLintestliverlungnsovarypancreprostskinstomathyrourina
Total # sample41  2   2        
GAIN (# sample)4       2        
LOSS (# sample) 1  2            
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=2

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=20)
Stat. for Synonymous SNVs
(# total SNVs=8)
Stat. for Deletions
(# total SNVs=1)
Stat. for Insertions
(# total SNVs=0)
There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr6:53141056-53141056p.?2
chr6:53134010-53134010p.G272A2
chr6:53135507-53135507p.I214V2
chr6:53160476-53160476p.L8I2
chr6:53139937-53139937p.S149S2
chr6:53133959-53133959p.N289S1
chr6:53139965-53139965p.T140M1
chr6:53156595-53156595p.L75L1
chr6:53133964-53133964p.L287L1
chr6:53139983-53139983p.K134T1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample23 3  2 1  11   1213
# mutation23 3  2 1  12   1213
nonsynonymous SNV12 3  1 1   2   12 2
synonymous SNV11    1    1      11
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr6:53134010p.W230C,ELOVL52
chr6:53135398p.T140M,ELOVL51
chr6:53141026p.K134T,ELOVL51
chr6:53135507p.G103E,ELOVL51
chr6:53156612p.R100H,ELOVL51
chr6:53138060p.Y92C,ELOVL51
chr6:53156718p.L70F,ELOVL51
chr6:53138102p.P34P,ELOVL51
chr6:53156755p.L258L,ELOVL51
chr6:53139895p.R22T,ELOVL51

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for ELOVL5 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for ELOVL5

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

AHCYL1,ANKHD1-EIF4EBP3,C1orf21,KIAA0825,DNAJC16,ELOVL5,FAM114A2,
FOXA1,GLUL,HNRNPH2,FAM214A,LOC728606,LRIG1,MCCC2,
NUDT12,PIGV,SIAE,SPATA6,SPG11,TMEM26,XBP1
ACOT4,AHCYL1,ANO10,APBB2,BNIP3L,C8orf34,ELOVL5,
GCLC,GPAM,HNMT,HSD17B4,IDH1,ISOC1,GSE1,
ME1,PBLD,PNPLA3,RNF14,SLC25A16,TMEM135,TTC39C

ADAM17,AKAP2,ASAP1,ELOVL5,FADS1,HDGFRP3,KIAA1586,
MSANTD4,MAP3K7,MAPRE1,NUP160,PALM2-AKAP2,PTPN1,RBL1,
RBMS1,RDX,RECQL,SGTB,STK4,TMEM170B,VASH2
C1orf216,CADM4,CLIP4,DEGS1,DENND5A,EFEMP2,ELOVL5,
FIBIN,GNAI2,GUCY1A3,KLHL5,MRAS,NCALD,SLC9B2,
PRNP,QKI,RAB31,RHOQ,SPG20,SULF1,ZCCHC24
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for ELOVL5


There's no related Drug.
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Cross referenced IDs for ELOVL5
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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