Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

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	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for RPL22

Basic gene info.	Gene symbol	RPL22
	Gene name	ribosomal protein L22
	Synonyms	EAP\|HBP15\|HBP15/L22\|L22
	Cytomap	UCSC genome browser: 1p36.31
	Genomic location	chr1 :6245079-6259679
	Type of gene	protein-coding
	RefGenes	NM_000983.3,
	Ensembl id	ENSG00000116251
	Description	60S ribosomal protein L22EBER-associated proteinEpstein-Barr virus small RNA-associated proteinEpstein-Barr-encoded RNA-associated proteinheparin-binding protein 15heparin-binding protein HBp15
	Modification date	20141207
dbXrefs	MIM : 180474
	HGNC : HGNC
	Ensembl : ENSG00000116251
	HPRD : 01602
	Vega : OTTHUMG00000000953
Protein	UniProt: P35268 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_RPL22
	BioGPS: 6146
	Gene Expression Atlas: ENSG00000116251
	The Human Protein Atlas: ENSG00000116251
Pathway	NCI Pathway Interaction Database: RPL22
	KEGG: RPL22
	REACTOME: RPL22
	ConsensusPathDB
	Pathway Commons: RPL22
Metabolism	MetaCyc: RPL22
	HUMANCyc: RPL22
Regulation	Ensembl's Regulation: ENSG00000116251
	miRBase: chr1 :6,245,079-6,259,679
	TargetScan: NM_000983
	cisRED: ENSG00000116251
Context	iHOP: RPL22
	cancer metabolism search in PubMed: RPL22
	UCL Cancer Institute: RPL22
Assigned class in ccmGDB	B - This gene belongs to cancer gene.

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Phenotypic Information for RPL22(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: RPL22
	Familial Cancer Database: RPL22

* This gene is included in those cancer gene databases.

						.
Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in UCEC ⁶,	Therapeutic Vulnerabilities in Cancer⁷

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
6 http://www.nature.com/nature/journal/v497/n7447/full/nature12113.html,
7Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
REACTOME_METABOLISM_OF_PROTEINS REACTOME_METABOLISM_OF_MRNA REACTOME_METABOLISM_OF_RNA

Others
OMIM	180474; gene.
Orphanet
Disease	KEGG Disease: RPL22
	MedGen: RPL22 (Human Medical Genetics with Condition)
	ClinVar: RPL22
Phenotype	MGI: RPL22 (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: RPL22

Mutations for RPL22

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

There's no structural variation information in COSMIC data for this gene.

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows RPL22 related fusion information.

ID	Head Gene						Tail Gene
Accession	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a
BU858788	MAP3K2	3	99	2	128062363	128062459	RPL22	93	464	1	6246094	6246465
CR738829	RPL22	1	314	1	6245384	6245697	DLC1	301	703	8	12940882	12941285
BF846664	RPL22	7	224	1	6245823	6246042	PCSK6	216	525	15	101870984	101871293

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

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Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

There's no copy number variation information in COSMIC data for this gene.

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SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=2

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Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=15)	Stat. for Synonymous SNVs (# total SNVs=1)

Stat. for Deletions (# total SNVs=3)	Stat. for Insertions (# total SNVs=2)

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Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr1:6257785-6257785	p.K15fs*5	6
chr1:6246808-6246808	p.A104D	2
chr1:6246877-6246877	p.?	2
chr1:6259633-6259633	p.M1L	2
chr1:6257784-6257785	p.K16fs*9	2
chr1:6246873-6246873	p.Y82*	1
chr1:6246817-6246817	p.R101H	1
chr1:6257826-6257826	p.?	1
chr1:6246818-6246818	p.R101C	1
chr1:6253009-6253009	p.E75*	1

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SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample		1		3			1		1			1		1			1			4
# mutation		1		3			1		1			1		1			1			4
nonsynonymous SNV				2			1		1			1		1			1			4
synonymous SNV		1		1

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chr1:6246817	p.R101C	1
chr1:6257713	p.R97C	1
chr1:6246818	p.L96L	1
chr1:6257793	p.Y90H	1
chr1:6246830	p.K89T	1
chr1:6246831	p.K88N	1
chr1:6246851	p.L86P	1
chr1:6246853	p.L56P	1
chr1:6246855	p.I47M	1
chr1:6246862	p.F42S	1

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for RPL22 in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for RPL22

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

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CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

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Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


NACA,RPL10A,RPL11,RPL12,RPL17,RPL22,RPL31, RPL34,RPL3,RPL4,RPL5,RPL6,RPL7A,RPLP0, RPS13,RPS18,RPS23,RPS25,RPS4X,RPS6,RPS8	BTF3,CCT4,EEF1A1,NPM1,RPL15,RPL22,RPL23A, RPL30,RPL32,RPL34,RPL35A,RPL5,RPL6,RPS15A, RPS23,RPS24,RPS27A,RPS3A,RPS4X,RPS6,RPS7

CAMTA1,HNRNPA1,LRRC47,MRTO4,NACA,PARK7,RMND1, RPL11,RPL12,RPL22,RPL34,RPL3,RPL37,RPL37A, RPL5,RPL6,RPS24,RPS25,RPS2,RPS27A,UBIAD1	CDKAL1,EIF2S3,EIF3H,EIF3L,EIF4B,FBL,HNRNPA1, HNRNPA1L2,IMPDH2,LARS,LTA4H,MATR3,NACA,PAIP2B, RPL11,RPL22,RPL23A,RPL37,RPL7,SMU1,ZNF830

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

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Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for RPL22

There's no related Drug.

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Cross referenced IDs for RPL22

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information