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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for RPLP1 |
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Phenotypic Information for RPLP1(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: RPLP1 |
Familial Cancer Database: RPLP1 |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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REACTOME_METABOLISM_OF_PROTEINS REACTOME_METABOLISM_OF_MRNA REACTOME_METABOLISM_OF_RNA |
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OMIM | |
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Disease | KEGG Disease: RPLP1 |
MedGen: RPLP1 (Human Medical Genetics with Condition) | |
ClinVar: RPLP1 | |
Phenotype | MGI: RPLP1 (International Mouse Phenotyping Consortium) |
PhenomicDB: RPLP1 |
Mutations for RPLP1 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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There's no structural variation information in COSMIC data for this gene. |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows RPLP1 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
CX751919 | RPLP1 | 1 | 254 | 15 | 69745181 | 69746060 | ASH2L | 255 | 612 | 8 | 37985814 | 37986470 | |
BM768334 | RPLP1 | 1 | 440 | 15 | 69745157 | 69747886 | SIAH2 | 438 | 497 | 3 | 150459044 | 150459103 | |
BU624867 | RPLP1 | 18 | 190 | 15 | 69747573 | 69747885 | DMD | 184 | 719 | X | 31165430 | 31196824 | |
BI006044 | WDR33 | 5 | 229 | 2 | 128471524 | 128476880 | RPLP1 | 223 | 347 | 15 | 69745187 | 69745311 | |
AY170823 | RPLP1 | 38 | 533 | 15 | 69745176 | 69747885 | RANBP2 | 530 | 2270 | 2 | 109389349 | 109400561 |
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There's no copy number variation information in COSMIC data for this gene. |
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Stat. for Non-Synonymous SNVs (# total SNVs=3) | (# total SNVs=1) |
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(# total SNVs=1) | (# total SNVs=0) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr15:69747774-69747774 | p.E91E | 2 |
chr15:69747800-69747800 | p.E100G | 1 |
chr15:69747810-69747810 | p.E103D | 1 |
chr15:69747836-69747836 | p.F113fs*>2 | 1 |
chr15:69745309-69745309 | p.A8T | 1 |
chr15:69745320-69745320 | p.Y11Y | 1 |
chr15:69746006-69746006 | p.L31L | 1 |
chr15:69747561-69747561 | p.G67V | 1 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 1 |   |   |   |   |   |   |   |   |   |   | 1 |   | 2 |   |   |   | 1 |   | 1 |
# mutation | 1 |   |   |   |   |   |   |   |   |   |   | 1 |   | 2 |   |   |   | 1 |   | 1 |
nonsynonymous SNV |   |   |   |   |   |   |   |   |   |   |   | 1 |   | 2 |   |   |   | 1 |   |   |
synonymous SNV | 1 |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   | 1 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr15:69747800 | p.A8T,RPLP1 | 1 |
chr15:69747810 | p.Y11Y,RPLP1 | 1 |
chr15:69745309 | p.L31L | 1 |
chr15:69745320 | p.G42V,RPLP1 | 1 |
chr15:69746006 | p.E75G,RPLP1 | 1 |
chr15:69747561 | p.E78D,RPLP1 | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for RPLP1 |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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ATP5D,FAU,RPL11,RPL13,RPL14,RPL18,RPL24, RPL27A,RPL28,RPL29,RPL32,RPL35,RPL36,RPL37A, RPL4,RPLP1,RPLP2,RPS15,RPS17,RPS8,RPS9 | PTRHD1,CUTA,EIF3G,EIF3I,NHP2L1,RPL10,RPL13, RPL13A,RPL18,RPL24,RPL27A,RPL35,RPL36,RPL8, RPLP1,RPS11,RPS15,RPS2,RPS3,RPS8,SNRPD2 |
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C15orf61,RPL10A,RPL12,RPL29,RPL35,RPL36,RPL37A, RPL4,RPLP0,RPLP1,RPLP2,RPS10,RPS11,RPS15, RPS16,RPS17,RPS19,RPS29,RPS3,RPS8,RPS9 | RPL13A,RPL15,RPL18,RPL18A,RPL19,RPL29,RPL32, RPL35,RPL7A,RPL8,RPLP0,RPLP1,RPS10,RPS11, RPS13,RPS14,RPS21,RPS3,RPS5,RPS8,RPS9 |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for RPLP1 |
There's no related Drug. |
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Cross referenced IDs for RPLP1 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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