Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

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	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for RPLP1

Basic gene info.	Gene symbol	RPLP1
	Gene name	ribosomal protein, large, P1
	Synonyms	LP1\|P1\|RPP1
	Cytomap	UCSC genome browser: 15q22
	Genomic location	chr15 :69745158-69747884
	Type of gene	protein-coding
	RefGenes	NM_001003.2, NM_213725.1,
	Ensembl id	ENSG00000137818
	Description	60S acidic ribosomal protein P1acidic ribosomal phosphoprotein P1
	Modification date	20141207
dbXrefs	MIM : 180520
	HGNC : HGNC
	Ensembl : ENSG00000137818
	HPRD : 01611
	Vega : OTTHUMG00000172087
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_RPLP1
	BioGPS: 6176
	Gene Expression Atlas: ENSG00000137818
	The Human Protein Atlas: ENSG00000137818
Pathway	NCI Pathway Interaction Database: RPLP1
	KEGG: RPLP1
	REACTOME: RPLP1
	ConsensusPathDB
	Pathway Commons: RPLP1
Metabolism	MetaCyc: RPLP1
	HUMANCyc: RPLP1
Regulation	Ensembl's Regulation: ENSG00000137818
	miRBase: chr15 :69,745,158-69,747,884
	TargetScan: NM_001003
	cisRED: ENSG00000137818
Context	iHOP: RPLP1
	cancer metabolism search in PubMed: RPLP1
	UCL Cancer Institute: RPLP1
Assigned class in ccmGDB	C

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Phenotypic Information for RPLP1(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: RPLP1
	Familial Cancer Database: RPLP1

* This gene is included in those cancer gene databases.

						.
Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in	Therapeutic Vulnerabilities in Cancer¹

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
REACTOME_METABOLISM_OF_PROTEINS REACTOME_METABOLISM_OF_MRNA REACTOME_METABOLISM_OF_RNA

Others
OMIM
Orphanet
Disease	KEGG Disease: RPLP1
	MedGen: RPLP1 (Human Medical Genetics with Condition)
	ClinVar: RPLP1
Phenotype	MGI: RPLP1 (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: RPLP1

Mutations for RPLP1

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

There's no structural variation information in COSMIC data for this gene.

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows RPLP1 related fusion information.

ID	Head Gene						Tail Gene
Accession	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a
CX751919	RPLP1	1	254	15	69745181	69746060	ASH2L	255	612	8	37985814	37986470
BM768334	RPLP1	1	440	15	69745157	69747886	SIAH2	438	497	3	150459044	150459103
BU624867	RPLP1	18	190	15	69747573	69747885	DMD	184	719	X	31165430	31196824
BI006044	WDR33	5	229	2	128471524	128476880	RPLP1	223	347	15	69745187	69745311
AY170823	RPLP1	38	533	15	69745176	69747885	RANBP2	530	2270	2	109389349	109400561

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

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Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

There's no copy number variation information in COSMIC data for this gene.

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SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=2

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Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=3)	Stat. for Synonymous SNVs (# total SNVs=1)

Stat. for Deletions (# total SNVs=1)	Stat. for Insertions (# total SNVs=0)
	There's no inserted snv.

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Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr15:69747774-69747774	p.E91E	2
chr15:69747561-69747561	p.G67V	1
chr15:69747800-69747800	p.E100G	1
chr15:69747810-69747810	p.E103D	1
chr15:69747836-69747836	p.F113fs*>2	1
chr15:69745309-69745309	p.A8T	1
chr15:69745320-69745320	p.Y11Y	1
chr15:69746006-69746006	p.L31L	1

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SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=1

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample	1											1		2				1		1
# mutation	1											1		2				1		1
nonsynonymous SNV												1		2				1
synonymous SNV	1																			1

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chr15:69747561	p.A8T,RPLP1	1
chr15:69747800	p.Y11Y,RPLP1	1
chr15:69747810	p.L31L	1
chr15:69745309	p.G42V,RPLP1	1
chr15:69745320	p.E75G,RPLP1	1
chr15:69746006	p.E78D,RPLP1	1

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for RPLP1 in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for RPLP1

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

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CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

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Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


ATP5D,FAU,RPL11,RPL13,RPL14,RPL18,RPL24, RPL27A,RPL28,RPL29,RPL32,RPL35,RPL36,RPL37A, RPL4,RPLP1,RPLP2,RPS15,RPS17,RPS8,RPS9	PTRHD1,CUTA,EIF3G,EIF3I,NHP2L1,RPL10,RPL13, RPL13A,RPL18,RPL24,RPL27A,RPL35,RPL36,RPL8, RPLP1,RPS11,RPS15,RPS2,RPS3,RPS8,SNRPD2

C15orf61,RPL10A,RPL12,RPL29,RPL35,RPL36,RPL37A, RPL4,RPLP0,RPLP1,RPLP2,RPS10,RPS11,RPS15, RPS16,RPS17,RPS19,RPS29,RPS3,RPS8,RPS9	RPL13A,RPL15,RPL18,RPL18A,RPL19,RPL29,RPL32, RPL35,RPL7A,RPL8,RPLP0,RPLP1,RPS10,RPS11, RPS13,RPS14,RPS21,RPS3,RPS5,RPS8,RPS9

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

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Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for RPLP1

There's no related Drug.

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Cross referenced IDs for RPLP1

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information