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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for RPS8 |
Basic gene info. | Gene symbol | RPS8 |
Gene name | ribosomal protein S8 | |
Synonyms | S8 | |
Cytomap | UCSC genome browser: 1p34.1-p32 | |
Genomic location | chr1 :45241245-45244412 | |
Type of gene | protein-coding | |
RefGenes | NM_001012.1, | |
Ensembl id | ENSG00000142937 | |
Description | 40S ribosomal protein S8OK/SW-cl.83 | |
Modification date | 20141207 | |
dbXrefs | MIM : 600357 | |
HGNC : HGNC | ||
Ensembl : ENSG00000142937 | ||
HPRD : 15969 | ||
Vega : OTTHUMG00000008494 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_RPS8 | |
BioGPS: 6202 | ||
Gene Expression Atlas: ENSG00000142937 | ||
The Human Protein Atlas: ENSG00000142937 | ||
Pathway | NCI Pathway Interaction Database: RPS8 | |
KEGG: RPS8 | ||
REACTOME: RPS8 | ||
ConsensusPathDB | ||
Pathway Commons: RPS8 | ||
Metabolism | MetaCyc: RPS8 | |
HUMANCyc: RPS8 | ||
Regulation | Ensembl's Regulation: ENSG00000142937 | |
miRBase: chr1 :45,241,245-45,244,412 | ||
TargetScan: NM_001012 | ||
cisRED: ENSG00000142937 | ||
Context | iHOP: RPS8 | |
cancer metabolism search in PubMed: RPS8 | ||
UCL Cancer Institute: RPS8 | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for RPS8(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: RPS8 |
Familial Cancer Database: RPS8 |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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REACTOME_METABOLISM_OF_PROTEINS REACTOME_METABOLISM_OF_MRNA REACTOME_METABOLISM_OF_RNA |
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OMIM | |
Orphanet | |
Disease | KEGG Disease: RPS8 |
MedGen: RPS8 (Human Medical Genetics with Condition) | |
ClinVar: RPS8 | |
Phenotype | MGI: RPS8 (International Mouse Phenotyping Consortium) |
PhenomicDB: RPS8 |
Mutations for RPS8 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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There's no structural variation information in COSMIC data for this gene. |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows RPS8 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
DA657610 | RPS8 | 1 | 63 | 1 | 45244065 | 45244127 | AKT2 | 64 | 574 | 19 | 40743955 | 40761110 | |
BG565964 | RPS8 | 1 | 70 | 1 | 45241536 | 45241605 | USP47 | 64 | 729 | 11 | 11970041 | 11977607 | |
AK129640 | GOLGA2 | 1 | 1916 | 9 | 131023519 | 131029481 | RPS8 | 1913 | 2138 | 1 | 45243738 | 45244409 | |
BM682967 | RPS8 | 17 | 225 | 1 | 45243774 | 45244427 | MAP3K7 | 226 | 706 | 6 | 91246054 | 91252594 | |
BF920614 | LRRC4C | 17 | 166 | 11 | 41080988 | 41081143 | RPS8 | 162 | 283 | 1 | 45243417 | 45243748 | |
AW948714 | RPS8 | 10 | 103 | 1 | 45241782 | 45242410 | NISCH | 99 | 382 | 3 | 52526529 | 52526812 | |
BQ082553 | DDA1 | 1 | 323 | 19 | 17431598 | 17431920 | RPS8 | 320 | 446 | 1 | 45242583 | 45242709 |
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There's no copy number variation information in COSMIC data for this gene. |
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Stat. for Non-Synonymous SNVs (# total SNVs=12) | (# total SNVs=7) |
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(# total SNVs=1) | (# total SNVs=0) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr1:45244310-45244310 | p.E194Q | 2 |
chr1:45243437-45243437 | p.L121L | 1 |
chr1:45242371-45242371 | p.V46I | 1 |
chr1:45243440-45243440 | p.G122G | 1 |
chr1:45244343-45244343 | p.R205S | 1 |
chr1:45242381-45242381 | p.R49L | 1 |
chr1:45243441-45243441 | p.R123C | 1 |
chr1:45242394-45242394 | p.K53K | 1 |
chr1:45243442-45243442 | p.R123L | 1 |
chr1:45243287-45243287 | p.C71W | 1 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 1 |   |   | 1 |   |   | 1 |   |   |   |   |   | 2 | 2 |   |   | 1 | 2 |   | 3 |
# mutation | 1 |   |   | 1 |   |   | 1 |   |   |   |   |   | 3 | 2 |   |   | 1 | 2 |   | 3 |
nonsynonymous SNV |   |   |   |   |   |   |   |   |   |   |   |   | 2 |   |   |   | 1 |   |   | 2 |
synonymous SNV | 1 |   |   | 1 |   |   | 1 |   |   |   |   |   | 1 | 2 |   |   |   | 2 |   | 1 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr1:45243294 | p.P120P | 1 |
chr1:45243434 | p.L121L | 1 |
chr1:45243437 | p.G122G | 1 |
chr1:45243440 | p.R123C | 1 |
chr1:45243441 | p.P131S | 1 |
chr1:45243675 | p.R141Q | 1 |
chr1:45243706 | p.N155N | 1 |
chr1:45241776 | p.E163E | 1 |
chr1:45243749 | p.C182C | 1 |
chr1:45242367 | p.R25R | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for RPS8 |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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RPL10,RPL11,RPL12,RPL18,RPL24,RPL27A,RPL31, RPL32,RPL36,RPL37,RPL37A,RPL5,RPL7A,RPLP0, RPLP2,RPS10,RPS18,RPS19,RPS2,RPS8,RPS9 | FBL,GNB2L1,RPL10,RPL10A,RPL12,RPL13,RPL13A, RPL14,RPL18,RPL19,RPL24,RPL27A,RPL36,RPL5, RPL7A,RPS11,RPS14,RPS2,RPS3,RPS6,RPS8 |
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RPL10A,RPL12,RPL24,RPL29,RPL32,RPL35,RPL36, RPL5,RPL7A,RPLP0,RPS10,RPS13,RPS14,RPS16, RPS18,RPS29,RPS3,RPS6,RPS7,RPS8,RPS9 | DPH5,EEF1B2,RPL10A,RPL15,RPL24,RPL27A,RPL32, RPL5,RPL7A,RPLP0,RPS10,RPS11,RPS14,RPS18, RPS3,RPS3A,RPS5,RPS6,RPS7,RPS8,RPSA |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for RPS8 |
There's no related Drug. |
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Cross referenced IDs for RPS8 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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