|
Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for RPS26 |
Basic gene info. | Gene symbol | RPS26 |
Gene name | ribosomal protein S26 | |
Synonyms | DBA10|S26 | |
Cytomap | UCSC genome browser: 12q13 | |
Genomic location | chr12 :56435685-56438007 | |
Type of gene | protein-coding | |
RefGenes | NM_001029.3, | |
Ensembl id | ENSG00000197728 | |
Description | 40S ribosomal protein S26 | |
Modification date | 20141219 | |
dbXrefs | MIM : 603701 | |
HGNC : HGNC | ||
Ensembl : ENSG00000197728 | ||
HPRD : 04743 | ||
Vega : OTTHUMG00000170139 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_RPS26 | |
BioGPS: 6231 | ||
Gene Expression Atlas: ENSG00000197728 | ||
The Human Protein Atlas: ENSG00000197728 | ||
Pathway | NCI Pathway Interaction Database: RPS26 | |
KEGG: RPS26 | ||
REACTOME: RPS26 | ||
ConsensusPathDB | ||
Pathway Commons: RPS26 | ||
Metabolism | MetaCyc: RPS26 | |
HUMANCyc: RPS26 | ||
Regulation | Ensembl's Regulation: ENSG00000197728 | |
miRBase: chr12 :56,435,685-56,438,007 | ||
TargetScan: NM_001029 | ||
cisRED: ENSG00000197728 | ||
Context | iHOP: RPS26 | |
cancer metabolism search in PubMed: RPS26 | ||
UCL Cancer Institute: RPS26 | ||
Assigned class in ccmGDB | C |
Top |
Phenotypic Information for RPS26(metabolism pathway, cancer, disease, phenome) |
![]() | |
Cancer | CGAP: RPS26 |
Familial Cancer Database: RPS26 |
* This gene is included in those cancer gene databases. |
. | ||||||||||||||||||||
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
![]() | |
REACTOME_METABOLISM_OF_PROTEINS REACTOME_METABOLISM_OF_MRNA REACTOME_METABOLISM_OF_RNA |
![]() | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: RPS26 |
MedGen: RPS26 (Human Medical Genetics with Condition) | |
ClinVar: RPS26 | |
Phenotype | MGI: RPS26 (International Mouse Phenotyping Consortium) |
PhenomicDB: RPS26 |
Mutations for RPS26 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
![]() |
There's no structural variation information in COSMIC data for this gene. |
![]() |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows RPS26 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
![]() |
Top |
![]() |
There's no copy number variation information in COSMIC data for this gene. |
Top |
![]() |
|
![]() |
Top |
![]() |
Stat. for Non-Synonymous SNVs (# total SNVs=5) | (# total SNVs=2) |
![]() | ![]() |
(# total SNVs=0) | (# total SNVs=0) |
Top |
![]() |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr12:56437901-56437901 | p.? | 3 |
chr12:56437240-56437240 | p.R92H | 1 |
chr12:56437912-56437912 | p.P108S | 1 |
chr12:56436228-56436228 | p.N8S | 1 |
chr12:56436231-56436231 | p.G9D | 1 |
chr12:56436328-56436328 | p.I41M | 1 |
chr12:56436346-56436346 | p.A47A | 1 |
chr12:56437168-56437168 | p.Y68C | 1 |
chr12:56437178-56437178 | p.L71L | 1 |
Top |
![]() |
|
![]() |
Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample |   |   | 1 | 1 | 1 |   |   |   | 2 |   |   | 1 | 1 |   |   |   |   |   |   | 1 |
# mutation |   |   | 1 | 1 | 1 |   |   |   | 2 |   |   | 1 | 1 |   |   |   |   |   |   | 1 |
nonsynonymous SNV |   |   |   |   |   |   |   |   | 2 |   |   | 1 | 1 |   |   |   |   |   |   | 1 |
synonymous SNV |   |   | 1 | 1 | 1 |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
Top |
![]() |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr12:56437178 | p.N8S | 1 |
chr12:56437240 | p.G9D | 1 |
chr12:56436228 | p.I41M | 1 |
chr12:56436231 | p.A47A | 1 |
chr12:56436328 | p.D52D | 1 |
chr12:56436346 | p.Y68C | 1 |
chr12:56436361 | p.L71L | 1 |
chr12:56437168 | p.R92H | 1 |
![]() |
![]() |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
![]() |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
Top |
Gene Expression for RPS26 |
![]() |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
![]() |
![]() |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
![]() |
Top |
![]() |
* This plots show the correlation between CNV and gene expression. |
![]() | |
![]() |
Top |
Gene-Gene Network Information |
![]() |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
![]() | |
ANKRD19P,C19orf60,EIF3G,MYL6,NACA2,OAZ1,PGLS, PIN1,RPL10A,RPL13,RPL13AP6,RPL36,RPL37A,RPL41, RPS15,RPS26,RPS26P11,RPS5,RPS9,TARBP2,TIMM13 | ANKRD19P,CNPY2,LOC728758,MRPL9,NME2P1,RPL13,RPL23A, RPL24,RPL26L1,RPL27A,RPL31,RPL38,RPL41,RPL6, RPS15,RPS17,RPS25,RPS26,RPS26P11,SNRPD2,UBE2I |
![]() | |
HLA-L,LOC100132247,LOC407835,FTX,PPIAL4G,RBMY1B,RPL13AP20, RPL13AP6,RPL21,RPL36A,RPS10P7,RPS26,RPS26P11,RPSAP9, SNORA25,SNORD76,SPDYE2,TBC1D3P2,TPI1P3,Z | BLOC1S1,CHIC2,COX6B1,JAGN1,MGST2,NDUFB4,NDUFC1, NDUFC2,OAZ1,POP4,PSMB3,ROMO1,RPS26,SF3B14, STX5,TMEM106C,EMC3,TMEM208,TPI1,UQCRQ,VPS25 |
![]() |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
Top |
![]() |
Top |
Pharmacological Information for RPS26 |
There's no related Drug. |
Top |
Cross referenced IDs for RPS26 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
Copyright © 2016-Present - The Univsersity of Texas Health Science Center at Houston @ |