Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

Home

Search

Download

 Statistics

Help

About Us

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for SAT1
Basic gene info.Gene symbolSAT1
Gene namespermidine/spermine N1-acetyltransferase 1
SynonymsDC21|KFSD|KFSDX|SAT|SSAT|SSAT-1
CytomapUCSC genome browser: Xp22.1
Genomic locationchrX :23801274-23804327
Type of geneprotein-coding
RefGenesNM_002970.3,
NR_027783.2,
Ensembl idENSG00000130066
Descriptiondiamine N-acetyltransferase 1diamine acetyltransferase 1polyamine N-acetyltransferase 1putrescine acetyltransferasespermidine/spermine N1-acetyltransferase alpha
Modification date20141222
dbXrefs MIM : 313020
HGNC : HGNC
Ensembl : ENSG00000130066
HPRD : 02431
Vega : OTTHUMG00000021256
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SAT1
BioGPS: 6303
Gene Expression Atlas: ENSG00000130066
The Human Protein Atlas: ENSG00000130066
PathwayNCI Pathway Interaction Database: SAT1
KEGG: SAT1
REACTOME: SAT1
ConsensusPathDB
Pathway Commons: SAT1
MetabolismMetaCyc: SAT1
HUMANCyc: SAT1
RegulationEnsembl's Regulation: ENSG00000130066
miRBase: chrX :23,801,274-23,804,327
TargetScan: NM_002970
cisRED: ENSG00000130066
ContextiHOP: SAT1
cancer metabolism search in PubMed: SAT1
UCL Cancer Institute: SAT1
Assigned class in ccmGDBC

Top
Phenotypic Information for SAT1(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: SAT1
Familial Cancer Database: SAT1
* This gene is included in those cancer gene databases.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_ARGININE_AND_PROLINE_METABOLISM
REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES
REACTOME_METABOLISM_OF_POLYAMINES

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: SAT1
MedGen: SAT1 (Human Medical Genetics with Condition)
ClinVar: SAT1
PhenotypeMGI: SAT1 (International Mouse Phenotyping Consortium)
PhenomicDB: SAT1

Mutations for SAT1
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows SAT1 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
BM263653MPHOSPH817178132022414420224305SAT1173560X2380393823804325
CA848235SAT114403X2380393823804327MPHOSPH8398555132022414820224305
H56980FYCO1113634600097346003790SAT1130426X2380397623804269
BQ023122SAT120258X2380408723804325FNDC3B2574443172117517172117705
BM263362SAT122403X2380393823804319MPHOSPH8398558132022414520224305
BE765420SAT117280X2380405523804318SERPINE12774457100781379100781547
BE180881SAT19102X2380308823803181SAT198273X2380294623803121
AW582417SAT18171X2380394823804110SAT1165267X2380384123803943
W39276SAT11111X2380394523804055SAT1109341X2380409523804326
W31613SAT11232X2380409523804326SAT1230304X2380394523804019
AW361033SAT112270X2380202123802281ANKH26556551471019314710493
BU674743SAT11796X2380424823804327SAT192253X2380395423804115

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

Top
check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

Top
check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=2

Top
check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=14)
Stat. for Synonymous SNVs
(# total SNVs=4)
Stat. for Deletions
(# total SNVs=0)
Stat. for Insertions
(# total SNVs=0)
There's no deleted snv.There's no inserted snv.

Top
check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr23:23803528-23803528p.V96M2
chr23:23801932-23801932p.G45D1
chr23:23803544-23803544p.R101T1
chr23:23801942-23801942p.E48D1
chr23:23803813-23803813p.R119K1
chr23:23801955-23801955p.H53Y1
chr23:23803814-23803814p.R119R1
chr23:23801965-23801965p.V56A1
chr23:23803819-23803819p.R121H1
chr23:23801977-23801977p.P60L1

Top
check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample 2 1  2 1  3  1    7
# mutation 2 1  2 2  3  1    7
nonsynonymous SNV 2 1  2 1  2  1    6
synonymous SNV        1  1       1
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

Top
check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chrX:23803528p.V96M2
chrX:23801955p.R121H1
chrX:23803899p.A145V1
chrX:23801965p.L148M1
chrX:23803921p.R155K1
chrX:23801977p.F4F1
chrX:23803928p.F157L1
chrX:23801978p.G45D1
chrX:23803931p.K158K1
chrX:23803448p.F51L1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for SAT1 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

Top
Gene Expression for SAT1

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
Top
check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


Top
Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ACOT9,ACTB,APOO,AVEN,B3GNT3,BRI3,SMCO4,
CLDN2,FUT3,LPXN,MALL,NXT1,PLAUR,PRDX4,
PRR18,S100A10,SAT1,SLC35C1,TAAR6,UGT2B7,VNN2
ADAP2,AIF1,CD86,GMFG,HCK,HLA-DMA,HLA-DMB,
IRF8,LAPTM5,LILRB4,LOC541471,NPL,OSTF1,PLEK,
RAB32,RAP2B,SAMSN1,SAT1,SLC11A1,SRGN,TMSB4XP8

ACOT9,ANKRD37,ANXA2,APOO,CIB1,COQ10B,GTF2A2,
ISG20,KIAA0895,MAFF,OBFC1,RAB11A,RAB9A,RND1,
S100A13,SAT1,SEC61B,SERTAD3,TMSB10,TRIM15,ZFYVE19
LINC00483,NMRK1,CCNDBP1,CLRN3,DERA,DNAJC17,DNAJC22,
GRAMD1C,HTATIP2,NDFIP2,NIT1,OCIAD2,PRSS3,RAB20,
SAT1,SEPHS2,SLC25A20,SLC25A5,SLC35D2,TRAF4,ZFAND2B
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

Top
check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

Top
Pharmacological Information for SAT1


There's no related Drug.
Top
Cross referenced IDs for SAT1
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



Copyright © 2016-Present - The Univsersity of Texas Health Science Center at Houston @
Site Policies | State of Texas