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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for SEC13 |
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Phenotypic Information for SEC13(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: SEC13 |
Familial Cancer Database: SEC13 |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
REACTOME_METABOLISM_OF_PROTEINS |
Others | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: SEC13 |
MedGen: SEC13 (Human Medical Genetics with Condition) | |
ClinVar: SEC13 | |
Phenotype | MGI: SEC13 (International Mouse Phenotyping Consortium) |
PhenomicDB: SEC13 |
Mutations for SEC13 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
There's no structural variation information in COSMIC data for this gene. |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows SEC13 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
BG256737 | MRPS10 | 1 | 339 | 6 | 42175255 | 42175596 | SEC13 | 335 | 725 | 3 | 10343270 | 10343668 | |
DW441224 | TOMM7 | 18 | 262 | 7 | 22857627 | 22862498 | SEC13 | 257 | 379 | 3 | 10342765 | 10342887 | |
BE161424 | KHNYN | 24 | 77 | 14 | 24908767 | 24908820 | SEC13 | 72 | 549 | 3 | 10343009 | 10353671 |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
There's no copy number variation information in COSMIC data for this gene. |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=25) | (# total SNVs=8) |
(# total SNVs=0) | (# total SNVs=0) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr3:10354352-10354352 | p.S76L | 2 |
chr3:10346764-10346764 | p.A221T | 2 |
chr3:10357052-10357052 | p.I39I | 2 |
chr3:10354321-10354321 | p.W86* | 2 |
chr3:10357109-10357109 | p.Q20H | 2 |
chr3:10346828-10346828 | p.D199D | 2 |
chr3:10342967-10342967 | p.E316G | 1 |
chr3:10354338-10354338 | p.R81W | 1 |
chr3:10345799-10345799 | p.K256* | 1 |
chr3:10347261-10347261 | p.N189S | 1 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 2 | 1 |   | 3 |   |   |   |   | 3 | 1 |   | 4 | 1 | 2 |   |   | 5 | 3 |   | 7 |
# mutation | 2 | 1 |   | 3 |   |   |   |   | 3 | 1 |   | 4 | 1 | 2 |   |   | 5 | 3 |   | 7 |
nonsynonymous SNV | 1 | 1 |   | 2 |   |   |   |   | 1 | 1 |   | 3 | 1 | 2 |   |   | 3 | 2 |   | 4 |
synonymous SNV | 1 |   |   | 1 |   |   |   |   | 2 |   |   | 1 |   |   |   |   | 2 | 1 |   | 3 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr3:10346828 | p.D185D,SEC13 | 2 |
chr3:10357052 | p.I25I,SEC13 | 2 |
chr3:10342967 | p.E302A,SEC13 | 1 |
chr3:10346776 | p.G124G,SEC13 | 1 |
chr3:10354321 | p.E302Q,SEC13 | 1 |
chr3:10342968 | p.P99P,SEC13 | 1 |
chr3:10346789 | p.S295S,SEC13 | 1 |
chr3:10354336 | p.C96C,SEC13 | 1 |
chr3:10342987 | p.G281R,SEC13 | 1 |
chr3:10346791 | p.D89N,SEC13 | 1 |
Other DBs for Point Mutations |
Copy Number for SEC13 in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for SEC13 |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
ARPC4,KXD1,PRADC1,BRK1,CIDECP,COPE,CTU2, DDX49,FAM58A,IL17RC,JAGN1,MED8,MOGS,MTMR14, OGG1,POLR2F,PRDX4,RPUSD3,SEC13,TADA3,TATDN2 | ADRM1,AP2S1,ARHGDIA,ASNA1,KXD1,CHMP2A,COPE, CUEDC2,DRAP1,GNB2,MRPL28,NAA10,PSMC3,PSMC4, LAMTOR2,SDF4,SEC13,SLC39A3,USP5,YIF1A,YKT6 |
AGR2,ARF4,ARPC4,GSKIP,C19orf10,CYSTM1,CIB1, COPE,CYB561D2,JAGN1,MPDU1,MRPL54,NDUFC1,POLR2L, PPIB,RPN1,S100P,SEC13,SEC61B,SERF2,SRA1 | AKR1A1,ATOX1,COA4,CNPY2,COQ6,GLRX,GLYATL1, GOSR2,GSTO1,NTMT1,MRPL55,P4HB,PPAPDC1B,SEC13, SEC24D,SLC35B1,SNRPA1,TFEC,TSPO2,YIF1A,YIPF5 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for SEC13 |
There's no related Drug. |
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Cross referenced IDs for SEC13 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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