|
Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for OXCT2 |
Basic gene info. | Gene symbol | OXCT2 |
Gene name | 3-oxoacid CoA transferase 2 | |
Synonyms | SCOTT | |
Cytomap | UCSC genome browser: 1p34 | |
Genomic location | chr1 :40235196-40237020 | |
Type of gene | protein-coding | |
RefGenes | NM_022120.1, | |
Ensembl id | ENSG00000198754 | |
Description | 3-oxoacid CoA-transferase 2A3-oxoacid-CoA transferase 2Asuccinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrialsuccinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrialtestis-specific succinyl CoA:3-oxoacid CoA-transferasetestis-specifi | |
Modification date | 20141207 | |
dbXrefs | MIM : 610289 | |
HGNC : HGNC | ||
Ensembl : ENSG00000198754 | ||
HPRD : 15093 | ||
Vega : OTTHUMG00000009249 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_OXCT2 | |
BioGPS: 64064 | ||
Gene Expression Atlas: ENSG00000198754 | ||
The Human Protein Atlas: ENSG00000198754 | ||
Pathway | NCI Pathway Interaction Database: OXCT2 | |
KEGG: OXCT2 | ||
REACTOME: OXCT2 | ||
ConsensusPathDB | ||
Pathway Commons: OXCT2 | ||
Metabolism | MetaCyc: OXCT2 | |
HUMANCyc: OXCT2 | ||
Regulation | Ensembl's Regulation: ENSG00000198754 | |
miRBase: chr1 :40,235,196-40,237,020 | ||
TargetScan: NM_022120 | ||
cisRED: ENSG00000198754 | ||
Context | iHOP: OXCT2 | |
cancer metabolism search in PubMed: OXCT2 | ||
UCL Cancer Institute: OXCT2 | ||
Assigned class in ccmGDB | C |
Top |
Phenotypic Information for OXCT2(metabolism pathway, cancer, disease, phenome) |
![]() | |
Cancer | CGAP: OXCT2 |
Familial Cancer Database: OXCT2 |
* This gene is included in those cancer gene databases. |
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
![]() | |
KEGG_BUTANOATE_METABOLISM |
![]() | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: OXCT2 |
MedGen: OXCT2 (Human Medical Genetics with Condition) | |
ClinVar: OXCT2 | |
Phenotype | MGI: OXCT2 (International Mouse Phenotyping Consortium) |
PhenomicDB: OXCT2 |
Mutations for OXCT2 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
![]() |
There's no structural variation information in COSMIC data for this gene. |
![]() |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows OXCT2 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
![]() |
Top |
![]() |
There's no copy number variation information in COSMIC data for this gene. |
Top |
![]() |
|
![]() |
Top |
![]() |
Stat. for Non-Synonymous SNVs (# total SNVs=17) | (# total SNVs=2) |
![]() | ![]() |
(# total SNVs=1) | (# total SNVs=0) |
![]() |
Top |
![]() |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr1:40236074-40236074 | p.L285R | 5 |
chr1:40235448-40235448 | p.D494N | 5 |
chr1:40236128-40236128 | p.D267G | 2 |
chr1:40236147-40236147 | p.V261I | 1 |
chr1:40235541-40235541 | p.V463M | 1 |
chr1:40236161-40236162 | p.P256fs*7 | 1 |
chr1:40235554-40235554 | p.T458T | 1 |
chr1:40236170-40236170 | p.A253V | 1 |
chr1:40235801-40235801 | p.F376C | 1 |
chr1:40236176-40236176 | p.V251G | 1 |
Top |
![]() |
|
![]() |
Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 1 | 1 |   | 2 | 1 |   | 1 |   |   |   |   |   |   |   |   |   | 3 | 1 |   | 3 |
# mutation | 1 | 1 |   | 2 | 1 |   | 1 |   |   |   |   |   |   |   |   |   | 3 | 1 |   | 3 |
nonsynonymous SNV | 1 | 1 |   | 2 | 1 |   | 1 |   |   |   |   |   |   |   |   |   | 2 | 1 |   | 2 |
synonymous SNV |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   | 1 |   |   | 1 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
Top |
![]() |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr1:40235514 | p.V472L | 2 |
chr1:40236234 | p.N220N | 1 |
chr1:40236245 | p.P511L | 1 |
chr1:40236246 | p.E469K | 1 |
chr1:40235396 | p.V463M | 1 |
chr1:40236268 | p.T458T | 1 |
chr1:40235523 | p.R278L | 1 |
chr1:40235541 | p.V269M | 1 |
chr1:40235554 | p.R268C | 1 |
chr1:40236095 | p.V232M | 1 |
![]() |
![]() |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
![]() |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
Top |
Gene Expression for OXCT2 |
![]() |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
![]() |
![]() |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
![]() |
Top |
![]() |
* This plots show the correlation between CNV and gene expression. |
![]() | |
![]() |
Top |
Gene-Gene Network Information |
![]() |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
![]() | |||||
ATP4A,CTPS1,EXO5,NXPE2,FKBP9P1,GAB4,GCK, MTHFD1L,NDUFS5,NFYC,OR9G4,OXCT2,PABPC4,PNLDC1, PPIE,RNASE2,RPL18A,SCMH1,SLC16A8,SLFNL1,ZFP69B | CEP131,B9D1,EMC10,CADM4,DNAL4,EBNA1BP2,GTF2F1, IGFALS,ISYNA1,NAT14,OXCT2,P4HTM,PES1,PICK1, PKP3,PRKAR1B,RHOV,SH3GLB2,SPINT2,TMEM198,TRIP6 | ||||
![]() | |||||
BRF1,ABHD16B,CDRT15P1,CN5H6.4,CT45A5,CTRL,DNMT3B, FADS3,NASP,OXCT2,POLR3H,PRRT3,SAC3D1,SAGE1, SART1,SNRNP70,TFAP2E,TRIM77,VAC14,ZDHHC8,ZMAT4 | ATAD3B,C5AR1,CCNE1,EWSR1,ITGAX,UVSSA,KRT7, LOC401010,LRRC37A3,NBEAL2,OXCT2,PFKFB3,RBM19,RBM28, SLCO4A1,SNRNP70,SYT12,TECPR1,VSIG1,WDR90,ZNF335 |
![]() |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
Top |
![]() |
Top |
Pharmacological Information for OXCT2 |
![]() |
DB Category | DB Name | DB's ID and Url link |
![]() |
* Gene Centered Interaction Network. |
![]() |
* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB00139 | 3-oxoacid CoA transferase 2 | approved; nutraceutical | Succinic acid | ![]() | ![]() |
Top |
Cross referenced IDs for OXCT2 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
Copyright © 2016-Present - The Univsersity of Texas Health Science Center at Houston @ |