Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for SLC2A1
Basic gene info.Gene symbolSLC2A1
Gene namesolute carrier family 2 (facilitated glucose transporter), member 1
SynonymsDYT17|DYT18|DYT9|EIG12|GLUT|GLUT-1|GLUT1|GLUT1DS|HTLVR|PED
CytomapUCSC genome browser: 1p34.2
Genomic locationchr1 :43391045-43424847
Type of geneprotein-coding
RefGenesNM_006516.2,
Ensembl idENSG00000117394
Descriptionglucose transporter type 1, erythrocyte/brainhepG2 glucose transporterhuman T-cell leukemia virus (I and II) receptorreceptor for HTLV-1 and HTLV-2solute carrier family 2, facilitated glucose transporter member 1
Modification date20141222
dbXrefs MIM : 138140
MIM : 143090
HGNC : HGNC
Ensembl : ENSG00000117394
HPRD : 00683
Vega : OTTHUMG00000007657
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SLC2A1
BioGPS: 6513
Gene Expression Atlas: ENSG00000117394
The Human Protein Atlas: ENSG00000117394
PathwayNCI Pathway Interaction Database: SLC2A1
KEGG: SLC2A1
REACTOME: SLC2A1
ConsensusPathDB
Pathway Commons: SLC2A1
MetabolismMetaCyc: SLC2A1
HUMANCyc: SLC2A1
RegulationEnsembl's Regulation: ENSG00000117394
miRBase: chr1 :43,391,045-43,424,847
TargetScan: NM_006516
cisRED: ENSG00000117394
ContextiHOP: SLC2A1
cancer metabolism search in PubMed: SLC2A1
UCL Cancer Institute: SLC2A1
Assigned class in ccmGDBA - This gene has a literature evidence and it belongs to cancer gene.
References showing role of SLC2A1 in cancer cell metabolism1. Ooi AT, Gomperts BN (2015) Molecular Pathways: Targeting Cellular Energy Metabolism in Cancer via Inhibition of SLC2A1 and LDHA. Clin Cancer Res 21: 2440-2444. doi: 10.1158/1078-0432.CCR-14-1209. pmid: 4452440. go to article
2. Grimm M, Munz A, Teriete P, Nadtotschi T, Reinert S (2014) GLUT-1(+)/TKTL1(+) coexpression predicts poor outcome in oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol 117: 743-753. doi: 10.1016/j.oooo.2014.02.007. go to article
3. Lopez-Serra P, Marcilla M, Villanueva A, Ramos-Fernandez A, Palau A, et al. (2014) A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect. Nat Commun 5: 3608. doi: 10.1038/ncomms4608. pmid: 3988805. go to article
4. Wang YD, Li SJ, Liao JX (2013) Inhibition of glucose transporter 1 (GLUT1) chemosensitized head and neck cancer cells to cisplatin. Technol Cancer Res Treat 12: 525-535. doi: 10.7785/tcrt.2012.500343. go to article

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Phenotypic Information for SLC2A1(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: SLC2A1
Familial Cancer Database: SLC2A1
* This gene is included in those cancer gene databases.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS
REACTOME_INTEGRATION_OF_ENERGY_METABOLISM
REACTOME_METABOLISM_OF_CARBOHYDRATES

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: SLC2A1
MedGen: SLC2A1 (Human Medical Genetics with Condition)
ClinVar: SLC2A1
PhenotypeMGI: SLC2A1 (International Mouse Phenotyping Consortium)
PhenomicDB: SLC2A1

Mutations for SLC2A1
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows SLC2A1 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
AW366615ACTR1A19810104240498104240595SLC2A19317614339633843396424
AW856224PERP352856138413330138428298SLC2A127951514339331943394674
AW352237SLC2A118914340685443406943ATN1812481270476617047828
BE828104BLMH191172857608428576174SLC2A18737214340676843407053

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
 
Mutation type/ Tissue IDbrcacnscervendomehaematopokidnLintestliverlungnsovarypancreprostskinstomathyrourina
Total # sample1  1      1      
GAIN (# sample)1  1      1      
LOSS (# sample)                 
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=4

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=26)
Stat. for Synonymous SNVs
(# total SNVs=19)
Stat. for Deletions
(# total SNVs=0)
Stat. for Insertions
(# total SNVs=0)
There's no deleted snv.There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr1:43392858-43392858p.F445L3
chr1:43396302-43396302p.A171T2
chr1:43396734-43396734p.F86F2
chr1:43395437-43395437p.R232C2
chr1:43408914-43408914p.I33L2
chr1:43396414-43396414p.C133C2
chr1:43408966-43408966p.A15A2
chr1:43396840-43396840p.R51H1
chr1:43395312-43395312p.L273L1
chr1:43393333-43393333p.A407A1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=4

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample32173 2    112  1010 7
# mutation42163 2    112  1010 7
nonsynonymous SNV3 162 2    1 2  35 3
synonymous SNV12  1       1   75 4
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr1:43392858p.F445L3
chr1:43395437p.F86F2
chr1:43396734p.R232C2
chr1:43396302p.A171T2
chr1:43396355p.P36R1
chr1:43393364p.S365S1
chr1:43396818p.G154G1
chr1:43395312p.G17G1
chr1:43396370p.A354A1
chr1:43393369p.R153H1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for SLC2A1 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for SLC2A1

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ADM,CA9,CDC20,DSG3,DUSP7,FERMT1,GJB3,
GJB5,KRT14,KRT16,KRT17,KRT5,KRT6A,KRT6B,
MICALL1,NDRG1,PERP,PKP1,SFN,SLC2A1,TRIM29
ANXA9,AP1M2,ATP6V1G1,CDH1,CLDN7,CRB3,DLG3,
EZR,FAM83H,HDAC1,HHAT,HN1L,KRT18,LRRC8E,
PIP4K2C,SDC1,SLC2A1,SLC35A2,SLC9A3R1,SPINT2,SUSD4

BEAN,ADIRF,C16orf74,CA6,CACNG6,CDA,ELOVL1,
EPHA2,EPHB6,GAS6-AS2,GJB3,KLK6,KLK8,PAK7,
PAPL,SLC1A5,SLC2A1,SOHLH1,TCHH,TUBB3,ZNF735
ACTG1,B3GNT3,BAIAP2L1,BCL10,CLDN4,DHDDS,EFNB1,
FA2H,GAK,KLF4,MIDN,PCSK7,PICK1,SH2B3,
SLC2A1,SLC35D1,TMEM2,TMPRSS2,TRIM11,ZDHHC18,ZDHHC5
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for SLC2A1
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB00318solute carrier family 2 (facilitated glucose transporter), member 1illicit; approvedCodeine
DB00295solute carrier family 2 (facilitated glucose transporter), member 1approved; investigationalMorphine


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Cross referenced IDs for SLC2A1
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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