Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

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	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for SLC19A1

Basic gene info.	Gene symbol	SLC19A1
	Gene name	solute carrier family 19 (folate transporter), member 1
	Synonyms	CHMD\|FOLT\|IFC1\|REFC\|RFC1
	Cytomap	UCSC genome browser: 21q22.3
	Genomic location	chr21 :46934628-46962385
	Type of gene	protein-coding
	RefGenes	NM_001205206.1, NM_001205207.1,NM_194255.2,NM_003056.2,
	Ensembl id	ENSG00000173638
	Description	IFC-1RFCfolate transporter 1intestinal folate carrier 1placental folate transporterreduced folate carrier proteinsolute carrier family 19 member 1
	Modification date	20141212
dbXrefs	MIM : 600424
	HGNC : HGNC
	Ensembl : ENSG00000173638
	HPRD : 02691
	Vega : OTTHUMG00000090397
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_SLC19A1
	BioGPS: 6573
	Gene Expression Atlas: ENSG00000173638
	The Human Protein Atlas: ENSG00000173638
Pathway	NCI Pathway Interaction Database: SLC19A1
	KEGG: SLC19A1
	REACTOME: SLC19A1
	ConsensusPathDB
	Pathway Commons: SLC19A1
Metabolism	MetaCyc: SLC19A1
	HUMANCyc: SLC19A1
Regulation	Ensembl's Regulation: ENSG00000173638
	miRBase: chr21 :46,934,628-46,962,385
	TargetScan: NM_001205206
	cisRED: ENSG00000173638
Context	iHOP: SLC19A1
	cancer metabolism search in PubMed: SLC19A1
	UCL Cancer Institute: SLC19A1
Assigned class in ccmGDB	C

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Phenotypic Information for SLC19A1(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: SLC19A1
	Familial Cancer Database: SLC19A1

* This gene is included in those cancer gene databases.

						.
Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in	Therapeutic Vulnerabilities in Cancer¹

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS

Others
OMIM
Orphanet
Disease	KEGG Disease: SLC19A1
	MedGen: SLC19A1 (Human Medical Genetics with Condition)
	ClinVar: SLC19A1
Phenotype	MGI: SLC19A1 (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: SLC19A1

Mutations for SLC19A1

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

There's no structural variation information in COSMIC data for this gene.

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows SLC19A1 related fusion information.

Head Gene

Tail Gene

Accession

Gene_a

qStart_a

qEnd_a

Chromosome_a

tStart_a

tEnd_a

Gene_a

qStart_a

qEnd_a

Chromosome_a

tStart_a

tEnd_a

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

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Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

There's no copy number variation information in COSMIC data for this gene.

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SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=5

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Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=30)	Stat. for Synonymous SNVs (# total SNVs=12)

Stat. for Deletions (# total SNVs=0)	Stat. for Insertions (# total SNVs=0)
There's no deleted snv.	There's no inserted snv.

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Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr21:46951556-46951556	p.P232P	5
chr21:46957794-46957794	p.H27R	4
chr21:46950811-46950811	p.V342I	2
chr21:46935678-46935678	p.E557V	1
chr21:46951464-46951464	p.R263Q	1
chr21:46945798-46945798	p.I409T	1
chr21:46951714-46951714	p.V180F	1
chr21:46951334-46951334	p.N306N	1
chr21:46951972-46951972	p.P94S	1
chr21:46935724-46935724	p.T542A	1

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SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample	3	1		5	1		4		2			2					6	3		11
# mutation	3	1		6	1		5		2			2					6	4		12
nonsynonymous SNV	2	1		6	1		1		1			1					4	3		9
synonymous SNV	1						4		1			1					2	1		3

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chr21:46951414	p.G240S,SLC19A1	2
chr21:46935726	p.V446L,SLC19A1	1
chr21:46951701	p.A262V,SLC19A1	1
chr21:46950869	p.A113A,SLC19A1	1
chr21:46957703	p.A441V,SLC19A1	1
chr21:46951450	p.Y247Y,SLC19A1	1
chr21:46935892	p.R108C,SLC19A1	1
chr21:46951793	p.S396F,SLC19A1	1
chr21:46950872	p.V104M,SLC19A1	1
chr21:46951483	p.V381V,SLC19A1	1

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for SLC19A1 in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for SLC19A1

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

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CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

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Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


BOP1,C20orf27,C21orf33,FAM207A,DAZAP1,EXOSC4,FBXL6, SLC52A2,TONSL,PFKL,PRR7,PUF60,PWP2,RECQL4, RRP1,RRP9,SLC19A1,TIGD5,U2AF1,VARS,WDR4	ACY1,BCAP31,BOK,DGAT1,IMPDH1,KLHL22,LPHN1, LRP3,PDXK,PIGS,PLEKHG6,POLR2E,POR,SCRN2, SLC19A1,SLC25A10,TALDO1,TMEM53,TST,TUBG1,TYSND1

ATAD3A,FAM207A,HGH1,DAZAP1,DDX51,DOHH,LONP1, NCLN,TONSL,NOC4L,PUS1,PWP2,RRP12,RRP1, RRP1B,SLC19A1,SRM,TMEM201,TRAP1,U2AF1,WDR4	ABHD15,ACAD10,ACADS,ACO2,ACSF3,ADH6,AFG3L2, FAM213B,SLC52A3,CEBPA,CLPTM1,CMBL,DQX1,EPHA1, GJB1,KBTBD11,PAQR5,PFKL,SLC19A1,SPNS1,TMEM19

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

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Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for SLC19A1

Cross-referenced pharmacological DB IDs from Uniprot

DB Category

DB Name

DB's ID and Url link

Drug-Gene Interaction Network

* Gene Centered Interaction Network.

* Drug Centered Interaction Network.

DrugBank ID	Target Name	Drug Groups	Generic Name	Drug Centered Network	Drug Structure
DB01234	solute carrier family 19 (folate transporter), member 1	approved; investigational	Dexamethasone
DB00515	solute carrier family 19 (folate transporter), member 1	approved	Cisplatin
DB00531	solute carrier family 19 (folate transporter), member 1	approved; investigational	Cyclophosphamide
DB00970	solute carrier family 19 (folate transporter), member 1	approved	Dactinomycin
DB00997	solute carrier family 19 (folate transporter), member 1	approved; investigational	Doxorubicin
DB01611	solute carrier family 19 (folate transporter), member 1	approved	Hydroxychloroquine
DB00795	solute carrier family 19 (folate transporter), member 1	approved	Sulfasalazine
DB00145	solute carrier family 19 (folate transporter), member 1	approved; nutraceutical	Glycine
DB00133	solute carrier family 19 (folate transporter), member 1	approved; nutraceutical	L-Serine
DB00293	solute carrier family 19 (folate transporter), member 1	approved; investigational	Raltitrexed
DB00158	solute carrier family 19 (folate transporter), member 1	approved; nutraceutical	Folic Acid
DB00987	solute carrier family 19 (folate transporter), member 1	approved; investigational	Cytarabine
DB00694	solute carrier family 19 (folate transporter), member 1	approved	Daunorubicin
DB00773	solute carrier family 19 (folate transporter), member 1	approved	Etoposide
DB00650	solute carrier family 19 (folate transporter), member 1	approved	Leucovorin
DB01033	solute carrier family 19 (folate transporter), member 1	approved	Mercaptopurine
DB00563	solute carrier family 19 (folate transporter), member 1	approved	Methotrexate
DB00635	solute carrier family 19 (folate transporter), member 1	approved	Prednisone
DB00541	solute carrier family 19 (folate transporter), member 1	approved; investigational	Vincristine
DB00544	solute carrier family 19 (folate transporter), member 1	approved	Fluorouracil
DB00762	solute carrier family 19 (folate transporter), member 1	approved; investigational	Irinotecan
DB00958	solute carrier family 19 (folate transporter), member 1	approved	Carboplatin
DB00642	solute carrier family 19 (folate transporter), member 1	approved; investigational	Pemetrexed

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Cross referenced IDs for SLC19A1

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information