Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

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	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for SNRPB

Basic gene info.	Gene symbol	SNRPB
	Gene name	small nuclear ribonucleoprotein polypeptides B and B1
	Synonyms	COD\|SNRPB1\|Sm-B/B'\|SmB/B'\|SmB/SmB'\|snRNP-B
	Cytomap	UCSC genome browser: 20p13
	Genomic location	chr20 :2442280-2451499
	Type of gene	protein-coding
	RefGenes	NM_003091.3, NM_198216.1,
	Ensembl id	ENSG00000125835
	Description	B polypeptide of Sm proteinSm protein B/B'sm-B/Sm-B'small nuclear ribonucleoprotein polypeptide Bsmall nuclear ribonucleoprotein polypeptides B and B'small nuclear ribonucleoprotein-associated proteins B and B'
	Modification date	20141207
dbXrefs	MIM : 182282
	HGNC : HGNC
	Ensembl : ENSG00000125835
	HPRD : 01655
	Vega : OTTHUMG00000031694
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_SNRPB
	BioGPS: 6628
	Gene Expression Atlas: ENSG00000125835
	The Human Protein Atlas: ENSG00000125835
Pathway	NCI Pathway Interaction Database: SNRPB
	KEGG: SNRPB
	REACTOME: SNRPB
	ConsensusPathDB
	Pathway Commons: SNRPB
Metabolism	MetaCyc: SNRPB
	HUMANCyc: SNRPB
Regulation	Ensembl's Regulation: ENSG00000125835
	miRBase: chr20 :2,442,280-2,451,499
	TargetScan: NM_003091
	cisRED: ENSG00000125835
Context	iHOP: SNRPB
	cancer metabolism search in PubMed: SNRPB
	UCL Cancer Institute: SNRPB
Assigned class in ccmGDB	C

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Phenotypic Information for SNRPB(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: SNRPB
	Familial Cancer Database: SNRPB

* This gene is included in those cancer gene databases.

						.
Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in	Therapeutic Vulnerabilities in Cancer¹

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
REACTOME_METABOLISM_OF_NON_CODING_RNA REACTOME_METABOLISM_OF_RNA

Others
OMIM
Orphanet
Disease	KEGG Disease: SNRPB
	MedGen: SNRPB (Human Medical Genetics with Condition)
	ClinVar: SNRPB
Phenotype	MGI: SNRPB (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: SNRPB

Mutations for SNRPB

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

There's no structural variation information in COSMIC data for this gene.

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows SNRPB related fusion information.

ID	Head Gene						Tail Gene
Accession	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a
BE252218	TCFL5	2	158	20	61476830	61476986	SNRPB	154	616	20	2444413	2451402
BG472482	TCFL5	23	179	20	61476830	61476986	SNRPB	175	440	20	2446421	2451402
BG472537	TCFL5	16	179	20	61476823	61476986	SNRPB	175	654	20	2444397	2451402
CB157749	BOK	1	76	2	242513231	242513306	SNRPB	65	451	20	2444502	2451415
BF871894	TMCC1	12	270	3	129512972	129513228	SNRPB	261	339	20	2443998	2444076

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

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Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

There's no copy number variation information in COSMIC data for this gene.

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SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=4

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Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=24)	Stat. for Synonymous SNVs (# total SNVs=7)

Stat. for Deletions (# total SNVs=1)	Stat. for Insertions (# total SNVs=1)

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Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr20:2442418-2442418	p.R236H	4
chr20:2443348-2443348	p.P207S	2
chr20:2444418-2444418	p.R132L	2
chr20:2443759-2443759	p.M179V	2
chr20:2444404-2444404	p.P137T	1
chr20:2446387-2446387	p.V78V	1
chr20:2448333-2448333	p.R25R	1
chr20:2446398-2446398	p.E75K	1
chr20:2448373-2448373	p.H12R	1
chr20:2443366-2443366	p.P201S	1

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SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample	2			4	1		2		2			2	3	2			6	2		2
# mutation	2			4	1		2		2			2	3	2			7	2		2
nonsynonymous SNV	2			3	1		1		1			1	3	1			5	1		1
synonymous SNV				1			1		1			1		1			2	1		1

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chr20:2442418	p.R236H	2
chr20:2446399	p.V3V,SNRPB	1
chr20:2443766	p.T143T,SNRPB	1
chr20:2446420	p.V141V,SNRPB	1
chr20:2443779	p.P137T,SNRPB	1
chr20:2446424	p.R132L,SNRPB	1
chr20:2443804	p.A110P,SNRPB	1
chr20:2446432	p.E83D,SNRPB	1
chr20:2443865	p.P233S	1
chr20:2448273	p.S79L,SNRPB	1

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for SNRPB in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for SNRPB

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

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CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

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Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


BAX,C1orf35,C20orf27,CCDC124,CDC34,CENPB,FAM96B, IDH3B,ITPA,LSM4,LSM7,MRPL55,MRPS26,MXD3, NDUFA11,NOC4L,NOP56,RALY,RPP21,SNRPB,PAM16	BCL2L12,ACTL10,CHCHD6,DCTPP1,EIF6,EXOSC4,HSPBP1, JMJD4,LSM7,LYPLA2,NHP2,NOC4L,OTUB1,PAFAH1B3, PUF60,PYCRL,SNRPB,STMN3,THOC6,TRAPPC6A,YIPF2

C20orf196,C20orf27,AP5S1,TMEM230,NDUFAF5,CRLS1,DDRGK1, IDH3B,ITPA,LINC00493,MKKS,MRPS26,NAA20,NOP56, PANK2,PCNA,PSMF1,SNRPB2,SNRPB,TASP1,TRMT6	BOLA3,HYPK,C1QBP,CDC123,DTYMK,EBNA1BP2,EMG1, MRPL52,MRTO4,NHP2,NME2,NPM3,NUP37,PFDN6, POP5,PPIH,RAN,SF3B5,SNRPB,STOML2,STRA13

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

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Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for SNRPB

There's no related Drug.

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Cross referenced IDs for SNRPB

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information