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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for SORD |
Basic gene info. | Gene symbol | SORD |
Gene name | sorbitol dehydrogenase | |
Synonyms | HEL-S-95n|SORD1 | |
Cytomap | UCSC genome browser: 15q15.3 | |
Genomic location | chr15 :45315301-45367287 | |
Type of gene | protein-coding | |
RefGenes | NM_003104.5, NR_034039.1, | |
Ensembl id | ENSG00000140263 | |
Description | L-iditol 2-dehydrogenaseepididymis secretory sperm binding protein Li 95n | |
Modification date | 20141207 | |
dbXrefs | MIM : 182500 | |
HGNC : HGNC | ||
HPRD : 01679 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SORD | |
BioGPS: 6652 | ||
Gene Expression Atlas: ENSG00000140263 | ||
The Human Protein Atlas: ENSG00000140263 | ||
Pathway | NCI Pathway Interaction Database: SORD | |
KEGG: SORD | ||
REACTOME: SORD | ||
ConsensusPathDB | ||
Pathway Commons: SORD | ||
Metabolism | MetaCyc: SORD | |
HUMANCyc: SORD | ||
Regulation | Ensembl's Regulation: ENSG00000140263 | |
miRBase: chr15 :45,315,301-45,367,287 | ||
TargetScan: NM_003104 | ||
cisRED: ENSG00000140263 | ||
Context | iHOP: SORD | |
cancer metabolism search in PubMed: SORD | ||
UCL Cancer Institute: SORD | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for SORD(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: SORD |
Familial Cancer Database: SORD |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM |
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OMIM | |
Orphanet | |
Disease | KEGG Disease: SORD |
MedGen: SORD (Human Medical Genetics with Condition) | |
ClinVar: SORD | |
Phenotype | MGI: SORD (International Mouse Phenotyping Consortium) |
PhenomicDB: SORD |
Mutations for SORD |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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- Statistics for Tissue and Mutation type | Top |
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- For Inter-chromosomal Variations |
There's no inter-chromosomal structural variation. |
- For Intra-chromosomal Variations |
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'. |
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Sample | Symbol_a | Chr_a | Start_a | End_a | Symbol_b | Chr_b | Start_b | End_b |
ovary | SORD | chr15 | 45319839 | 45319859 | C15orf43 | chr15 | 45270948 | 45270968 |
pancreas | SORD | chr15 | 45315924 | 45315944 | SORD | chr15 | 45328658 | 45328678 |
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract) |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows SORD related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
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There's no copy number variation information in COSMIC data for this gene. |
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Stat. for Non-Synonymous SNVs (# total SNVs=21) | (# total SNVs=10) |
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(# total SNVs=0) | (# total SNVs=0) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr15:45361180-45361180 | p.Q239L | 4 |
chr15:45364534-45364534 | p.N269T | 3 |
chr15:45353270-45353270 | p.R91C | 3 |
chr15:45365724-45365724 | p.P357L | 2 |
chr15:45353365-45353365 | p.T122T | 2 |
chr15:45353379-45353379 | p.G127A | 2 |
chr15:45357499-45357499 | p.G152G | 2 |
chr15:45353277-45353277 | p.A93V | 1 |
chr15:45357543-45357543 | p.R167T | 1 |
chr15:45365692-45365692 | p.I346I | 1 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample |   | 2 |   | 3 |   |   | 1 |   | 2 |   |   | 2 | 1 |   |   |   | 3 | 2 |   | 7 |
# mutation |   | 2 |   | 3 |   |   | 1 |   | 2 |   |   | 2 | 2 |   |   |   | 3 | 2 |   | 7 |
nonsynonymous SNV |   | 2 |   | 2 |   |   | 1 |   | 2 |   |   | 2 | 1 |   |   |   | 2 | 2 |   | 3 |
synonymous SNV |   |   |   | 1 |   |   |   |   |   |   |   |   | 1 |   |   |   | 1 |   |   | 4 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr15:45353314 | p.R91C | 2 |
chr15:45353270 | p.F105L | 2 |
chr15:45364534 | p.G238D | 1 |
chr15:45353347 | p.P244P | 1 |
chr15:45364616 | p.I27I | 1 |
chr15:45353372 | p.T251M | 1 |
chr15:45364620 | p.M66V | 1 |
chr15:45357499 | p.N269T | 1 |
chr15:45365692 | p.D90E | 1 |
chr15:45357500 | p.G296G | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for SORD |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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AACS,ACSL3,AKR1D1,ETNK2,FCN2,FKBP5,GSTM5, GSTT2,IVD,MYOM2,NANOG,PNLIPRP3,PTPLAD1,PXMP4, RNASE11,RNASE12,SCP2,SLCO1B1,SORD,TMEM62,TMPRSS9 | ACER1,B4GALNT2,CCBL1,HES3,HGD,HIST1H4G,ISX, LOC145837,LOC360030,LYZL2,MARCH10,MCCC2,NOTO,OR7D4, PAFAH2,PON3,SLC50A1,SORD,TUBA3C,TUBA3D,TUBA3E | ||||
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C1QBP,CECR5,CHAC2,EIF5AL1,ESCO2,ETFA,MARS2, MMACHC,MPI,MRPL44,MRPL46,MTFMT,ORC1,PBK, PKP2,PNP,PRMT5,RRM2,SCO1,SNRNP40,SORD | CD1B,CLEC6A,CRELD2,CXCL1,GNA15,GPX2,LRG1, MMP12,MTHFD2,NOS2,PDIA6,PDZK1IP1,PI3,PPIB, RTEL1,SLC38A5,SORD,TMEM173,TNFRSF6B,TNFSF13,TSTA3 |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for SORD |
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DB Category | DB Name | DB's ID and Url link |
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* Gene Centered Interaction Network. |
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* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB00157 | sorbitol dehydrogenase | approved; nutraceutical | NADH | ![]() | ![]() |
DB01907 | sorbitol dehydrogenase | experimental | Nicotinamide-Adenine-Dinucleotide | ![]() | ![]() |
DB04478 | sorbitol dehydrogenase | experimental | Cp-166572, 2-Hydroxymethyl-4-(4-N,N-Dimethylaminosulfonyl-1-Piperazino)-Pyrimidine | ![]() | ![]() |
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Cross referenced IDs for SORD |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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