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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for SRP14 |
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Phenotypic Information for SRP14(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: SRP14 |
Familial Cancer Database: SRP14 |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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REACTOME_METABOLISM_OF_PROTEINS |
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OMIM | |
Orphanet | |
Disease | KEGG Disease: SRP14 |
MedGen: SRP14 (Human Medical Genetics with Condition) | |
ClinVar: SRP14 | |
Phenotype | MGI: SRP14 (International Mouse Phenotyping Consortium) |
PhenomicDB: SRP14 |
Mutations for SRP14 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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There's no structural variation information in COSMIC data for this gene. |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows SRP14 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
BQ015130 | SRP14 | 18 | 551 | 15 | 40328242 | 40329550 | C1orf198 | 545 | 690 | 1 | 230973433 | 230973578 | |
CN337981 | SRP14 | 2 | 135 | 15 | 40330565 | 40331323 | EME2 | 136 | 615 | 16 | 1824946 | 1825879 | |
AA984265 | SRP14 | 1 | 141 | 15 | 40331085 | 40331369 | ABCB11 | 142 | 458 | 2 | 169869119 | 169869435 | |
BE836999 | NUMB | 35 | 229 | 14 | 73753961 | 73759574 | SRP14 | 218 | 320 | 15 | 40331128 | 40331374 |
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There's no copy number variation information in COSMIC data for this gene. |
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Stat. for Non-Synonymous SNVs (# total SNVs=7) | (# total SNVs=2) |
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(# total SNVs=2) | (# total SNVs=0) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr15:40328597-40328597 | p.A116A | 3 |
chr15:40328572-40328572 | p.T125A | 2 |
chr15:40330494-40330496 | p.K66delK | 2 |
chr15:40330490-40330490 | p.S68I | 2 |
chr15:40328590-40328590 | p.A119T | 1 |
chr15:40328614-40328614 | p.A111P | 1 |
chr15:40328617-40328617 | p.A110T | 1 |
chr15:40328663-40328663 | p.L94L | 1 |
chr15:40328689-40328689 | p.L86F | 1 |
chr15:40329196-40329196 | p.K78K | 1 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   | 1 | 1 |   | 2 |
# mutation |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   | 1 | 1 |   | 2 |
nonsynonymous SNV |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   | 1 | 1 |   | 2 |
synonymous SNV |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr15:40328545 | p.A134S | 1 |
chr15:40328590 | p.A119T | 1 |
chr15:40330484 | p.V70A | 1 |
chr15:40330529 | p.K55T | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for SRP14 |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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ATP5G2,C12orf10,EMC7,C15orf57,HYPK,TMA7,COX17, COX6A1,COX7C,DNAJC17,EID1,IMP3,MGST2,MTHFS, NDUFA2,NDUFAF1,NDUFC1,PARK7,SERF2,SRP14,EMC4 | C17orf49,C19orf43,BRK1,DAD1,DYNLRB1,EXOSC1,FAM127B, GABARAP,JTB,KRTCAP2,LSM3,OST4,POLE4,PSENEN, RBX1,RNF181,SEC61B,SNRPG,SRP14,TAF10,TOMM6 |
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EMC7,C15orf57,HYPK,COPS2,DNAJC17,FAM103A1,FAM96A, FBXO22,IMP3,MTHFS,NDUFAF1,NOP10,PSMA4,RAB11A, RPUSD2,RSL24D1,SEC11A,SERF2,SNRPG,SRP14,EMC4 | ACTR10,ATP5J,BUD31,C14orf119,CALM2,CAPZA2,MOB4, MYEOV2,NDUFA4,NDUFA6,NDUFB6,NDUFB8,NDUFV2,NEDD8, RBX1,SARNP,SRP14,TRAPPC3,TTC1,UBL5,UQCR11 |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for SRP14 |
There's no related Drug. |
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Cross referenced IDs for SRP14 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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