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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for STAR |
Basic gene info. | Gene symbol | STAR |
Gene name | steroidogenic acute regulatory protein | |
Synonyms | STARD1 | |
Cytomap | UCSC genome browser: 8p11.2 | |
Genomic location | chr8 :38000217-38008600 | |
Type of gene | protein-coding | |
RefGenes | NM_000349.2, NM_001007243.1, | |
Ensembl id | ENSG00000147465 | |
Description | START domain containing 1START domain-containing protein 1StAR-related lipid transfer (START) domain containing 1cholesterol traffickermitochondrial steroid acute regulatory proteinsteroid acute regulatory proteinsteroidogenic acute regulatorsteroi | |
Modification date | 20141207 | |
dbXrefs | MIM : 600617 | |
HGNC : HGNC | ||
HPRD : 02794 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_STAR | |
BioGPS: 6770 | ||
Gene Expression Atlas: ENSG00000147465 | ||
The Human Protein Atlas: ENSG00000147465 | ||
Pathway | NCI Pathway Interaction Database: STAR | |
KEGG: STAR | ||
REACTOME: STAR | ||
ConsensusPathDB | ||
Pathway Commons: STAR | ||
Metabolism | MetaCyc: STAR | |
HUMANCyc: STAR | ||
Regulation | Ensembl's Regulation: ENSG00000147465 | |
miRBase: chr8 :38,000,217-38,008,600 | ||
TargetScan: NM_000349 | ||
cisRED: ENSG00000147465 | ||
Context | iHOP: STAR | |
cancer metabolism search in PubMed: STAR | ||
UCL Cancer Institute: STAR | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for STAR(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: STAR |
Familial Cancer Database: STAR |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS |
Others | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: STAR |
MedGen: STAR (Human Medical Genetics with Condition) | |
ClinVar: STAR | |
Phenotype | MGI: STAR (International Mouse Phenotyping Consortium) |
PhenomicDB: STAR |
Mutations for STAR |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
There's no structural variation information in COSMIC data for this gene. |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows STAR related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
BP196904 | STAR | 1 | 351 | 8 | 38005805 | 38008468 | MAP7 | 346 | 579 | 6 | 136862458 | 136862691 | |
AV705820 | ELL3 | 1 | 112 | 15 | 44084511 | 44085212 | STAR | 112 | 593 | 8 | 38003812 | 38008344 | |
AV703221 | GPI | 1 | 212 | 19 | 34893033 | 34893244 | STAR | 213 | 411 | 8 | 38001350 | 38001602 | |
DA569262 | STAR | 1 | 470 | 8 | 38001809 | 38008570 | STAR | 460 | 665 | 8 | 38006158 | 38008365 |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
Mutation type/ Tissue ID | brca | cns | cerv | endome | haematopo | kidn | Lintest | liver | lung | ns | ovary | pancre | prost | skin | stoma | thyro | urina | |||
Total # sample | 1 |   |   |   |   |   | 1 |   |   |   |   |   |   |   |   |   |   | |||
GAIN (# sample) | 1 |   |   |   |   |   | 1 |   |   |   |   |   |   |   |   |   |   | |||
LOSS (# sample) |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract) |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=19) | (# total SNVs=8) |
(# total SNVs=0) | (# total SNVs=1) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr8:38008285-38008285 | p.R18C | 2 |
chr8:38003900-38003900 | p.V124V | 1 |
chr8:38005844-38005844 | p.G60G | 1 |
chr8:38002793-38002793 | p.A231P | 1 |
chr8:38008297-38008297 | p.Y14D | 1 |
chr8:38003905-38003905 | p.E123K | 1 |
chr8:38005846-38005846 | p.? | 1 |
chr8:38002821-38002821 | p.G221G | 1 |
chr8:38003950-38003950 | p.V108M | 1 |
chr8:38006175-38006175 | p.R54R | 1 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample |   |   |   | 3 | 1 |   | 3 |   | 1 |   |   | 3 | 4 | 2 |   |   | 1 | 1 | 1 | 4 |
# mutation |   |   |   | 3 | 1 |   | 3 |   | 1 |   |   | 3 | 4 | 2 |   |   | 1 | 1 | 1 | 5 |
nonsynonymous SNV |   |   |   | 1 |   |   | 1 |   | 1 |   |   | 3 | 4 | 1 |   |   | 1 |   |   | 4 |
synonymous SNV |   |   |   | 2 | 1 |   | 2 |   |   |   |   |   |   | 1 |   |   |   | 1 | 1 | 1 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr8:38008285 | p.R18C | 2 |
chr8:38005844 | p.L260M | 1 |
chr8:38003626 | p.T47T | 1 |
chr8:38006175 | p.D246N | 1 |
chr8:38003855 | p.P45T | 1 |
chr8:38006196 | p.V28E | 1 |
chr8:38003900 | p.L243L | 1 |
chr8:38006204 | p.V28M | 1 |
chr8:38003950 | p.F206F | 1 |
chr8:38006254 | p.E169K | 1 |
Other DBs for Point Mutations |
Copy Number for STAR in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for STAR |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
C18orf54,C1orf94,ADTRP,CCKBR,CD70,DCBLD1,ELOVL4, FAM19A3,FAM81A,FETUB,H2BFXP,LRRC8D,LINC00092,PCBP4, RSPO4,SOAT2,STARD6,TLX1NB,TUBB2B,UNC93A,WBSCR28 | BCAN,C1QTNF4,C8orf74,CCDC70,DPPA2,FLJ46361,GJA10, GLT6D1,KCNK4,KRTAP4-2,KRTAP9-4,MGC16703,LINC00029,NTRK3, OR2T2,OR4A5,OR5F1,OR8H2,OR9G9,PIWIL3,PLA2G1B, RAB9BP1,SNORA32,STARD6, |
ADAM3A,CT47A1,CYP3A4,DKK4,GCG,ITGA2B,KRTAP19-8, MBD3L1,C7orf62,MOG,MT1F,MT1G,MT1H,MYOZ2, NKX2-6,NRG1,CFAP221,SNORA14A,STARD6,TMPRSS11BNL,XAGE2 | C11orf40,CGB7,HHLA1,HORMAD2,IQCA1,LOC145474,OR11H12, OR1B1,OR2AK2,PPP3R2,RDH8,SNORA54,SNORA5B,SPINK9, SSX3,STARD6,TAS2R41,TAS |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for STAR |
There's no related Drug. |
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Cross referenced IDs for STAR |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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