Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for SULT1E1
Basic gene info.Gene symbolSULT1E1
Gene namesulfotransferase family 1E, estrogen-preferring, member 1
SynonymsEST|EST-1|ST1E1|STE
CytomapUCSC genome browser: 4q13.1
Genomic locationchr4 :70706929-70725870
Type of geneprotein-coding
RefGenesNM_005420.2,
Ensembl idENSG00000109193
Descriptionestrogen sulfotransferaseestrone sulfotransferasesulfotransferase 1E1sulfotransferase, estrogen-preferring
Modification date20141207
dbXrefs MIM : 600043
HGNC : HGNC
Ensembl : ENSG00000109193
HPRD : 08966
Vega : OTTHUMG00000129403
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SULT1E1
BioGPS: 6783
Gene Expression Atlas: ENSG00000109193
The Human Protein Atlas: ENSG00000109193
PathwayNCI Pathway Interaction Database: SULT1E1
KEGG: SULT1E1
REACTOME: SULT1E1
ConsensusPathDB
Pathway Commons: SULT1E1
MetabolismMetaCyc: SULT1E1
HUMANCyc: SULT1E1
RegulationEnsembl's Regulation: ENSG00000109193
miRBase: chr4 :70,706,929-70,725,870
TargetScan: NM_005420
cisRED: ENSG00000109193
ContextiHOP: SULT1E1
cancer metabolism search in PubMed: SULT1E1
UCL Cancer Institute: SULT1E1
Assigned class in ccmGDBC

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Phenotypic Information for SULT1E1(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: SULT1E1
Familial Cancer Database: SULT1E1
* This gene is included in those cancer gene databases.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_SULFUR_METABOLISM

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: SULT1E1
MedGen: SULT1E1 (Human Medical Genetics with Condition)
ClinVar: SULT1E1
PhenotypeMGI: SULT1E1 (International Mouse Phenotyping Consortium)
PhenomicDB: SULT1E1

Mutations for SULT1E1
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows SULT1E1 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
 
Mutation type/ Tissue IDbrcacnscervendomehaematopokidnLintestliverlungnsovarypancreprostskinstomathyrourina
Total # sample        1 1      
GAIN (# sample)        1 1      
LOSS (# sample)                 
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=4

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=39)
Stat. for Synonymous SNVs
(# total SNVs=11)
Stat. for Deletions
(# total SNVs=0)
Stat. for Insertions
(# total SNVs=0)
There's no deleted snv.There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr4:70709918-70709918p.E245K4
chr4:70721060-70721060p.R77Q3
chr4:70721061-70721061p.R77*3
chr4:70707773-70707773p.F275C3
chr4:70710024-70710024p.F209F2
chr4:70709895-70709895p.S252S2
chr4:70707775-70707775p.K274K2
chr4:70720005-70720005p.S100Y2
chr4:70709970-70709970p.S227S2
chr4:70721017-70721017p.?1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=4

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample 3 4  3 11 42   93 9
# mutation 3 4  3 11 42   103 9
nonsynonymous SNV 2 3  3  1 42   82 7
synonymous SNV 1 1    1       21 2
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr4:70709918p.E245K4
chr4:70721060p.R77Q3
chr4:70713465p.S100Y2
chr4:70720005p.K181R2
chr4:70707775p.K274K2
chr4:70713508p.I223T1
chr4:70715228p.Q94K1
chr4:70721110p.F209F1
chr4:70709983p.M89I1
chr4:70715248p.K205Q1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for SULT1E1 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for SULT1E1

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

CCDC129,CCDC83,CCR8,CT45A2,DLK1,EMR3,FAIM2,
FZD4,GABRA2,GLYCAM1,KRT24,OR5J2,PCTP,BPIFA1,
PROKR2,RGS8,SLC17A1,SLC5A5,SLC6A14,SULT1E1,VMO1
ALDH3B2,APOC1,CHIT1,HS6ST3,KCNK1,KIAA1257,KLK7,
LINGO2,LPCAT3,MAGEC3,MGAM,NDP,NKX2-6,PKD2L1,
PNLIPRP2,PTN,SHISA2,SLC2A1,SLC8A2,SULT1E1,WFDC6

ABCC11,C11orf53,CAMK2N2,CATSPERG,ACKR4___CX3CR1,CDH12,CLCN1,
DMBX1,EDN2,FUT4,GPX5,LOC144742,MGC45800,LINC00111,
ODAM,OR4C3,QRFPR,RNF126P1,SLC28A1,SULT1E1,TDRD12
ACE,ALDOB,CREB3L3,CYP3A4,DPEP1,ENPEP,FGF19,
GSTA1,GSTA2,HAPLN4,MGAM,MUC17,NAT8,NTS,
RBP2,SHBG,SLC10A2,SLC5A12,SLC6A4,SULT1E1,UGT1A4
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for SULT1E1
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB01176sulfotransferase family 1E, estrogen-preferring, member 1approvedCyclizine
DB01812sulfotransferase family 1E, estrogen-preferring, member 1experimentalAdenosine-3'-5'-Diphosphate
DB02902sulfotransferase family 1E, estrogen-preferring, member 1experimental3'-Phosphate-Adenosine-5'-Phosphate Sulfate
DB03346sulfotransferase family 1E, estrogen-preferring, member 1experimental3,5,3',5'-Tetrachloro-Biphenyl-4,4'-Diol
DB00988sulfotransferase family 1E, estrogen-preferring, member 1approvedDopamine
DB00655sulfotransferase family 1E, estrogen-preferring, member 1approvedEstrone
DB03255sulfotransferase family 1E, estrogen-preferring, member 1experimentalPhenol
DB00286sulfotransferase family 1E, estrogen-preferring, member 1approvedConjugated Estrogens
DB00783sulfotransferase family 1E, estrogen-preferring, member 1approved; investigationalEstradiol
DB00481sulfotransferase family 1E, estrogen-preferring, member 1approved; investigationalRaloxifene
DB01708sulfotransferase family 1E, estrogen-preferring, member 1nutraceuticalDehydroepiandrosterone
DB00675sulfotransferase family 1E, estrogen-preferring, member 1approvedTamoxifen


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Cross referenced IDs for SULT1E1
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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