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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for SULT1E1 |
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Phenotypic Information for SULT1E1(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: SULT1E1 |
Familial Cancer Database: SULT1E1 |
* This gene is included in those cancer gene databases. |
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
KEGG_SULFUR_METABOLISM |
Mutations for SULT1E1 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
There's no structural variation information in COSMIC data for this gene. |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows SULT1E1 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
Mutation type/ Tissue ID | brca | cns | cerv | endome | haematopo | kidn | Lintest | liver | lung | ns | ovary | pancre | prost | skin | stoma | thyro | urina | |||
Total # sample |   |   |   |   |   |   |   |   | 1 |   | 1 |   |   |   |   |   |   | |||
GAIN (# sample) |   |   |   |   |   |   |   |   | 1 |   | 1 |   |   |   |   |   |   | |||
LOSS (# sample) |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract) |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=39) | (# total SNVs=11) |
(# total SNVs=0) | (# total SNVs=0) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr4:70709918-70709918 | p.E245K | 4 |
chr4:70721060-70721060 | p.R77Q | 3 |
chr4:70721061-70721061 | p.R77* | 3 |
chr4:70707773-70707773 | p.F275C | 3 |
chr4:70710024-70710024 | p.F209F | 2 |
chr4:70709895-70709895 | p.S252S | 2 |
chr4:70707775-70707775 | p.K274K | 2 |
chr4:70720005-70720005 | p.S100Y | 2 |
chr4:70709970-70709970 | p.S227S | 2 |
chr4:70721017-70721017 | p.? | 1 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample |   | 3 |   | 4 |   |   | 3 |   | 1 | 1 |   | 4 | 2 |   |   |   | 9 | 3 |   | 9 |
# mutation |   | 3 |   | 4 |   |   | 3 |   | 1 | 1 |   | 4 | 2 |   |   |   | 10 | 3 |   | 9 |
nonsynonymous SNV |   | 2 |   | 3 |   |   | 3 |   |   | 1 |   | 4 | 2 |   |   |   | 8 | 2 |   | 7 |
synonymous SNV |   | 1 |   | 1 |   |   |   |   | 1 |   |   |   |   |   |   |   | 2 | 1 |   | 2 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr4:70709918 | p.E245K | 4 |
chr4:70721060 | p.R77Q | 3 |
chr4:70713465 | p.S100Y | 2 |
chr4:70720005 | p.K181R | 2 |
chr4:70707775 | p.K274K | 2 |
chr4:70713508 | p.I223T | 1 |
chr4:70715228 | p.Q94K | 1 |
chr4:70721110 | p.F209F | 1 |
chr4:70709983 | p.M89I | 1 |
chr4:70715248 | p.K205Q | 1 |
Other DBs for Point Mutations |
Copy Number for SULT1E1 in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for SULT1E1 |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
CCDC129,CCDC83,CCR8,CT45A2,DLK1,EMR3,FAIM2, FZD4,GABRA2,GLYCAM1,KRT24,OR5J2,PCTP,BPIFA1, PROKR2,RGS8,SLC17A1,SLC5A5,SLC6A14,SULT1E1,VMO1 | ALDH3B2,APOC1,CHIT1,HS6ST3,KCNK1,KIAA1257,KLK7, LINGO2,LPCAT3,MAGEC3,MGAM,NDP,NKX2-6,PKD2L1, PNLIPRP2,PTN,SHISA2,SLC2A1,SLC8A2,SULT1E1,WFDC6 | ||||
ABCC11,C11orf53,CAMK2N2,CATSPERG,ACKR4___CX3CR1,CDH12,CLCN1, DMBX1,EDN2,FUT4,GPX5,LOC144742,MGC45800,LINC00111, ODAM,OR4C3,QRFPR,RNF126P1,SLC28A1,SULT1E1,TDRD12 | ACE,ALDOB,CREB3L3,CYP3A4,DPEP1,ENPEP,FGF19, GSTA1,GSTA2,HAPLN4,MGAM,MUC17,NAT8,NTS, RBP2,SHBG,SLC10A2,SLC5A12,SLC6A4,SULT1E1,UGT1A4 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for SULT1E1 |
Cross-referenced pharmacological DB IDs from Uniprot |
DB Category | DB Name | DB's ID and Url link |
Drug-Gene Interaction Network |
* Gene Centered Interaction Network. |
* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB01176 | sulfotransferase family 1E, estrogen-preferring, member 1 | approved | Cyclizine | ||
DB01812 | sulfotransferase family 1E, estrogen-preferring, member 1 | experimental | Adenosine-3'-5'-Diphosphate | ||
DB02902 | sulfotransferase family 1E, estrogen-preferring, member 1 | experimental | 3'-Phosphate-Adenosine-5'-Phosphate Sulfate | ||
DB03346 | sulfotransferase family 1E, estrogen-preferring, member 1 | experimental | 3,5,3',5'-Tetrachloro-Biphenyl-4,4'-Diol | ||
DB00988 | sulfotransferase family 1E, estrogen-preferring, member 1 | approved | Dopamine | ||
DB00655 | sulfotransferase family 1E, estrogen-preferring, member 1 | approved | Estrone | ||
DB03255 | sulfotransferase family 1E, estrogen-preferring, member 1 | experimental | Phenol | ||
DB00286 | sulfotransferase family 1E, estrogen-preferring, member 1 | approved | Conjugated Estrogens | ||
DB00783 | sulfotransferase family 1E, estrogen-preferring, member 1 | approved; investigational | Estradiol | ||
DB00481 | sulfotransferase family 1E, estrogen-preferring, member 1 | approved; investigational | Raloxifene | ||
DB01708 | sulfotransferase family 1E, estrogen-preferring, member 1 | nutraceutical | Dehydroepiandrosterone | ||
DB00675 | sulfotransferase family 1E, estrogen-preferring, member 1 | approved | Tamoxifen |
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Cross referenced IDs for SULT1E1 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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