Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for SULT1A1
Basic gene info.Gene symbolSULT1A1
Gene namesulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SynonymsHAST1/HAST2|P-PST|PST|ST1A1|ST1A3|STP|STP1|TSPST1
CytomapUCSC genome browser: 16p12.1
Genomic locationchr16 :28616907-28634907
Type of geneprotein-coding
RefGenesNM_001055.3,
NM_177529.2,NM_177530.2,NM_177534.2,NM_177536.3,
Ensembl idENSG00000196502
DescriptionP-PST 1aryl sulfotransferase 1phenol-sulfating phenol sulfotransferase 1sulfotransferase 1A1thermostable phenol sulfotransferase1ts-PST
Modification date20141207
dbXrefs MIM : 171150
HGNC : HGNC
Ensembl : ENSG00000196502
HPRD : 01372
Vega : OTTHUMG00000131765
ProteinUniProt: P50225
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SULT1A1
BioGPS: 6817
Gene Expression Atlas: ENSG00000196502
The Human Protein Atlas: ENSG00000196502
PathwayNCI Pathway Interaction Database: SULT1A1
KEGG: SULT1A1
REACTOME: SULT1A1
ConsensusPathDB
Pathway Commons: SULT1A1
MetabolismMetaCyc: SULT1A1
HUMANCyc: SULT1A1
RegulationEnsembl's Regulation: ENSG00000196502
miRBase: chr16 :28,616,907-28,634,907
TargetScan: NM_001055
cisRED: ENSG00000196502
ContextiHOP: SULT1A1
cancer metabolism search in PubMed: SULT1A1
UCL Cancer Institute: SULT1A1
Assigned class in ccmGDBA - This gene has a literature evidence and it belongs to cancer gene.
References showing role of SULT1A1 in cancer cell metabolism1. Ellingjord-Dale M, Lee E, Couto E, Ozhand A, Qureshi SA, et al. (2012) Polymorphisms in hormone metabolism and growth factor genes and mammographic density in Norwegian postmenopausal hormone therapy users and non-users. Breast Cancer Res 14: R135. go to article

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Phenotypic Information for SULT1A1(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: SULT1A1
Familial Cancer Database: SULT1A1
* This gene is included in those cancer gene databases.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_SULFUR_METABOLISM

check002.gifOthers
OMIM 171150; gene.
Orphanet
DiseaseKEGG Disease: SULT1A1
MedGen: SULT1A1 (Human Medical Genetics with Condition)
ClinVar: SULT1A1
PhenotypeMGI: SULT1A1 (International Mouse Phenotyping Consortium)
PhenomicDB: SULT1A1

Mutations for SULT1A1
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows SULT1A1 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
 
Mutation type/ Tissue IDbrcacnscervendomehaematopokidnLintestliverlungnsovarypancreprostskinstomathyrourina
Total # sample        1        
GAIN (# sample)        1        
LOSS (# sample)                 
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=5

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=28)
Stat. for Synonymous SNVs
(# total SNVs=8)
Stat. for Deletions
(# total SNVs=0)
Stat. for Insertions
(# total SNVs=0)
There's no deleted snv.There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr16:28617413-28617413p.F247L5
chr16:28617511-28617511p.S214F2
chr16:28620121-28620121p.P19L2
chr16:28620148-28620148p.P10L2
chr16:28618277-28618277p.G165E2
chr16:28618279-28618279p.V164V2
chr16:28619845-28619845p.F76F1
chr16:28620120-28620120p.P19P1
chr16:28618303-28618303p.D156E1
chr16:28619681-28619681p.A101A1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample1  3  1 2  222  16214
# mutation1  4  2 1  222  20215
nonsynonymous SNV1  3    1   22  122 4
synonymous SNV   1  2    2    8 11
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr16:28620121p.P19L,SULT1A12
chr16:28617511p.S136F,SULT1A12
chr16:28618127p.L20L,SULT1A11
chr16:28619685p.P176H,SULT1A11
chr16:28620117p.P72H,SULT1A11
chr16:28617391p.P166P,SULT1A11
chr16:28618135p.D56Y,SULT1A11
chr16:28619805p.V18L,SULT1A11
chr16:28617420p.V165I,SULT1A11
chr16:28618163p.D120Y,SULT1A11

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for SULT1A1 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for SULT1A1

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

CCDC159,CHCHD5,ECI1,DECR2,DNAJC17,FAM195A,FLYWCH2,
GAMT,HAGH,HEXIM2,MRPS34,NDUFB10,NME3,PIGQ,
ROGDI,STUB1,SULT1A1,SULT1A2,TMEM219,TNFRSF18,ZNF688
AKR1C1,AKR1C2,AKR1C3,ANXA2,ANXA2P2,ANXA5,C15orf59,
COPRS,COLEC11,CPNE2,EPHX1,FADS3,KDELR3,MARCH2,
PCBP3,PIR,SLC7A4,SPATA9,SULT1A1,SULT1A2,TUBB6

ANKS4B,C1orf210,DHRS11,GDPD3,GPA33,ITM2C,KLC4,
LRRC19,MAPK3,MEP1A,SLC51B,PAFAH2,PBLD,PPP1R14D,
PRSS8,RETSAT,SGK2,SULT1A1,SULT1A2,TRHDE,TTC38
ACAA1,ACOT8,CHP2,CYB561A3,DHRS11,ESPN,HPS1,
KLC4,MGAT4B,PLEKHG6,POLD4,SEPHS2,SLC25A5,SPATA2L,
SPHK2,SULT1A1,SULT1A2,TPRN,ULK3,VRK3,ZFAND2B
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for SULT1A1
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link
ChemistryChEMBL CHEMBL1743291; -.
Organism-specific databasesPharmGKB PA343; -.
Organism-specific databasesCTD 6817; -.

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB01812sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1experimentalAdenosine-3'-5'-Diphosphate
DB04417sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1experimentalP-Nitrophenol
DB00818sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1approved; investigationalPropofol
DB00350sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1approvedMinoxidil
DB00316sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1approvedAcetaminophen
DB00988sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1approvedDopamine
DB00655sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1approvedEstrone
DB03255sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1experimentalPhenol
DB00286sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1approvedConjugated Estrogens
DB00675sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1approvedTamoxifen
DB00783sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1approved; investigationalEstradiol
DB01708sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1nutraceuticalDehydroepiandrosterone
DB00564sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1approved; investigationalCarbamazepine
DB00451sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1approvedLevothyroxine


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Cross referenced IDs for SULT1A1
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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