Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

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	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for SULT1A1

Basic gene info.	Gene symbol	SULT1A1
	Gene name	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
	Synonyms	HAST1/HAST2\|P-PST\|PST\|ST1A1\|ST1A3\|STP\|STP1\|TSPST1
	Cytomap	UCSC genome browser: 16p12.1
	Genomic location	chr16 :28616907-28634907
	Type of gene	protein-coding
	RefGenes	NM_001055.3, NM_177529.2,NM_177530.2,NM_177534.2,NM_177536.3,
	Ensembl id	ENSG00000196502
	Description	P-PST 1aryl sulfotransferase 1phenol-sulfating phenol sulfotransferase 1sulfotransferase 1A1thermostable phenol sulfotransferase1ts-PST
	Modification date	20141207
dbXrefs	MIM : 171150
	HGNC : HGNC
	Ensembl : ENSG00000196502
	HPRD : 01372
	Vega : OTTHUMG00000131765
Protein	UniProt: P50225 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_SULT1A1
	BioGPS: 6817
	Gene Expression Atlas: ENSG00000196502
	The Human Protein Atlas: ENSG00000196502
Pathway	NCI Pathway Interaction Database: SULT1A1
	KEGG: SULT1A1
	REACTOME: SULT1A1
	ConsensusPathDB
	Pathway Commons: SULT1A1
Metabolism	MetaCyc: SULT1A1
	HUMANCyc: SULT1A1
Regulation	Ensembl's Regulation: ENSG00000196502
	miRBase: chr16 :28,616,907-28,634,907
	TargetScan: NM_001055
	cisRED: ENSG00000196502
Context	iHOP: SULT1A1
	cancer metabolism search in PubMed: SULT1A1
	UCL Cancer Institute: SULT1A1
Assigned class in ccmGDB	A - This gene has a literature evidence and it belongs to cancer gene.
References showing role of SULT1A1 in cancer cell metabolism	1. Ellingjord-Dale M, Lee E, Couto E, Ozhand A, Qureshi SA, et al. (2012) Polymorphisms in hormone metabolism and growth factor genes and mammographic density in Norwegian postmenopausal hormone therapy users and non-users. Breast Cancer Res 14: R135. go to article

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Phenotypic Information for SULT1A1(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: SULT1A1
	Familial Cancer Database: SULT1A1

* This gene is included in those cancer gene databases.


Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in	Therapeutic Vulnerabilities in Cancer¹

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
KEGG_SULFUR_METABOLISM

Others
OMIM	171150; gene.
Orphanet
Disease	KEGG Disease: SULT1A1
	MedGen: SULT1A1 (Human Medical Genetics with Condition)
	ClinVar: SULT1A1
Phenotype	MGI: SULT1A1 (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: SULT1A1

Mutations for SULT1A1

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

There's no structural variation information in COSMIC data for this gene.

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows SULT1A1 related fusion information.

Head Gene

Tail Gene

Accession

Gene_a

qStart_a

qEnd_a

Chromosome_a

tStart_a

tEnd_a

Gene_a

qStart_a

qEnd_a

Chromosome_a

tStart_a

tEnd_a

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

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Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

Mutation type/ Tissue ID

brca

cns

cerv

endome

haematopo

kidn

Lintest

liver

lung

ovary

pancre

prost

skin

stoma

thyro

urina

Total # sample

GAIN (# sample)

LOSS (# sample)

cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=5

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Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=28)	Stat. for Synonymous SNVs (# total SNVs=8)

Stat. for Deletions (# total SNVs=0)	Stat. for Insertions (# total SNVs=0)
There's no deleted snv.	There's no inserted snv.

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Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr16:28617413-28617413	p.F247L	5
chr16:28617511-28617511	p.S214F	2
chr16:28620121-28620121	p.P19L	2
chr16:28620148-28620148	p.P10L	2
chr16:28618277-28618277	p.G165E	2
chr16:28618279-28618279	p.V164V	2
chr16:28619666-28619666	p.K106K	1
chr16:28619842-28619842	p.M77I	1
chr16:28617510-28617510	p.S214S	1
chr16:28620117-28620117	p.L20L	1

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SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample	1			3			1		2			2	2	2			16	2	1	4
# mutation	1			4			2		1			2	2	2			20	2	1	5
nonsynonymous SNV	1			3					1				2	2			12	2		4
synonymous SNV				1			2					2					8		1	1

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chr16:28620121	p.P19L,SULT1A1	2
chr16:28617511	p.S136F,SULT1A1	2
chr16:28620051	p.T51S,SULT1A1	1
chr16:28631441	p.G87E,SULT1A1	1
chr16:28618084	p.L42L,SULT1A1	1
chr16:28619681	p.V86V,SULT1A1	1
chr16:28620093	p.L28L,SULT1A1	1
chr16:28618127	p.V86A,SULT1A1	1
chr16:28619685	p.L20L,SULT1A1	1
chr16:28620117	p.P176H,SULT1A1	1

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for SULT1A1 in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for SULT1A1

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

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CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

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Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


CCDC159,CHCHD5,ECI1,DECR2,DNAJC17,FAM195A,FLYWCH2, GAMT,HAGH,HEXIM2,MRPS34,NDUFB10,NME3,PIGQ, ROGDI,STUB1,SULT1A1,SULT1A2,TMEM219,TNFRSF18,ZNF688	AKR1C1,AKR1C2,AKR1C3,ANXA2,ANXA2P2,ANXA5,C15orf59, COPRS,COLEC11,CPNE2,EPHX1,FADS3,KDELR3,MARCH2, PCBP3,PIR,SLC7A4,SPATA9,SULT1A1,SULT1A2,TUBB6

ANKS4B,C1orf210,DHRS11,GDPD3,GPA33,ITM2C,KLC4, LRRC19,MAPK3,MEP1A,SLC51B,PAFAH2,PBLD,PPP1R14D, PRSS8,RETSAT,SGK2,SULT1A1,SULT1A2,TRHDE,TTC38	ACAA1,ACOT8,CHP2,CYB561A3,DHRS11,ESPN,HPS1, KLC4,MGAT4B,PLEKHG6,POLD4,SEPHS2,SLC25A5,SPATA2L, SPHK2,SULT1A1,SULT1A2,TPRN,ULK3,VRK3,ZFAND2B

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

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Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for SULT1A1

Cross-referenced pharmacological DB IDs from Uniprot

DB Category	DB Name	DB's ID and Url link
Chemistry	ChEMBL	CHEMBL1743291; -.
Organism-specific databases	PharmGKB	PA343; -.
Organism-specific databases	CTD	6817; -.

Drug-Gene Interaction Network

* Gene Centered Interaction Network.

* Drug Centered Interaction Network.

DrugBank ID	Target Name	Drug Groups	Generic Name	Drug Centered Network	Drug Structure
DB01812	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1	experimental	Adenosine-3'-5'-Diphosphate
DB04417	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1	experimental	P-Nitrophenol
DB00818	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1	approved; investigational	Propofol
DB00350	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1	approved	Minoxidil
DB00316	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1	approved	Acetaminophen
DB00988	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1	approved	Dopamine
DB00655	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1	approved	Estrone
DB03255	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1	experimental	Phenol
DB00286	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1	approved	Conjugated Estrogens
DB00675	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1	approved	Tamoxifen
DB00783	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1	approved; investigational	Estradiol
DB01708	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1	nutraceutical	Dehydroepiandrosterone
DB00564	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1	approved; investigational	Carbamazepine
DB00451	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1	approved	Levothyroxine

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Cross referenced IDs for SULT1A1

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information