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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for SULT2B1 |
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Phenotypic Information for SULT2B1(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: SULT2B1 |
Familial Cancer Database: SULT2B1 |
* This gene is included in those cancer gene databases. |
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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KEGG_SULFUR_METABOLISM |
Mutations for SULT2B1 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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- Statistics for Tissue and Mutation type | Top |
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- For Inter-chromosomal Variations |
There's no inter-chromosomal structural variation. |
- For Intra-chromosomal Variations |
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'. |
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Sample | Symbol_a | Chr_a | Start_a | End_a | Symbol_b | Chr_b | Start_b | End_b |
ovary | SULT2B1 | chr19 | 49080487 | 49080687 | SULT2B1 | chr19 | 49086294 | 49086494 |
ovary | SULT2B1 | chr19 | 49080590 | 49080610 | SULT2B1 | chr19 | 49086383 | 49086403 |
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract) |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows SULT2B1 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
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There's no copy number variation information in COSMIC data for this gene. |
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Stat. for Non-Synonymous SNVs (# total SNVs=26) | (# total SNVs=15) |
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(# total SNVs=0) | (# total SNVs=0) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr19:49096065-49096065 | p.L198L | 2 |
chr19:49096081-49096081 | p.? | 2 |
chr19:49090527-49090527 | p.E71K | 2 |
chr19:49102399-49102399 | p.C263C | 2 |
chr19:49102445-49102445 | p.D279N | 2 |
chr19:49079250-49079250 | p.G27S | 2 |
chr19:49079294-49079294 | p.Q41H | 1 |
chr19:49100068-49100068 | p.V225I | 1 |
chr19:49090617-49090617 | p.Q101* | 1 |
chr19:49102469-49102469 | p.R287W | 1 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 2 |   | 1 | 4 | 1 |   |   |   | 2 |   |   | 2 |   | 1 |   |   | 8 |   | 1 | 5 |
# mutation | 2 |   | 1 | 4 | 1 |   |   |   | 2 |   |   | 2 |   | 1 |   |   | 9 |   | 1 | 7 |
nonsynonymous SNV | 1 |   | 1 | 4 | 1 |   |   |   |   |   |   | 2 |   | 1 |   |   | 6 |   |   | 4 |
synonymous SNV | 1 |   |   |   |   |   |   |   | 2 |   |   |   |   |   |   |   | 3 |   | 1 | 3 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr19:49100007 | p.D279N,SULT2B1 | 2 |
chr19:49102445 | p.G204G,SULT2B1 | 2 |
chr19:49079174 | p.E71K,SULT2B1 | 1 |
chr19:49096055 | p.P74T,SULT2B1 | 1 |
chr19:49102508 | p.R280C,SULT2B1 | 1 |
chr19:49079265 | p.L106P,SULT2B1 | 1 |
chr19:49096070 | p.R283H,SULT2B1 | 1 |
chr19:49102616 | p.P112L,SULT2B1 | 1 |
chr19:49090502 | p.E300Q,SULT2B1 | 1 |
chr19:49090527 | p.F116F,SULT2B1 | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for SULT2B1 |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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BLVRB,CHMP2A,COX6A1,GAMT,HSPB1,KRT18,KRT8, LMTK3,LOC113230,MFSD5,MRFAP1,NDUFA2,PLA2G4F,PPDPF, PTOV1,SERTAD3,SIGIRR,SPR,SULT2B1,VAMP8,WIBG | ANXA9,AP1M2,ARFIP2,ATP2C2,KDF1,CRB3,FAM174B, GOLT1A,GPR39,GRTP1,IRX3,LRRC48,MRPL49,PHYHD1, PRRG2,RAB17,SPDEF,SPINT2,SULT2B1,TMEM25,ZBTB42 | ||||
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AIM1L,CHMP2A,COPZ1,DNAJC15,EFNB1,GRTP1,H2AFY, KRT18,KRT8,LMTK3,METTL7B,NDUFA1,NSDHL,PNKD, PRAP1,PRR13,RAB20,SSR4,SULT2B1,TMEM117,WDR13 | ABCG5,ABCG8,ALDOB,ERICH4,TMEM252,DEFA5,DHDH, DPEP1,GLTPD2,GSTA2,HAPLN4,MEP1B,MGAM,NAT8, NTS,SLC10A2,SLC6A4,SP8,SULT2B1,TMEM229A,TREH |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for SULT2B1 |
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DB Category | DB Name | DB's ID and Url link |
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* Gene Centered Interaction Network. |
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* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB01708 | sulfotransferase family, cytosolic, 2B, member 1 | nutraceutical | Dehydroepiandrosterone | ![]() | ![]() |
DB01812 | sulfotransferase family, cytosolic, 2B, member 1 | experimental | Adenosine-3'-5'-Diphosphate | ![]() | ![]() |
DB02789 | sulfotransferase family, cytosolic, 2B, member 1 | experimental | Pregnenolone | ![]() | ![]() |
DB03309 | sulfotransferase family, cytosolic, 2B, member 1 | experimental | N-Cyclohexyltaurine | ![]() | ![]() |
DB00988 | sulfotransferase family, cytosolic, 2B, member 1 | approved | Dopamine | ![]() | ![]() |
DB00655 | sulfotransferase family, cytosolic, 2B, member 1 | approved | Estrone | ![]() | ![]() |
DB03255 | sulfotransferase family, cytosolic, 2B, member 1 | experimental | Phenol | ![]() | ![]() |
DB00783 | sulfotransferase family, cytosolic, 2B, member 1 | approved; investigational | Estradiol | ![]() | ![]() |
DB00675 | sulfotransferase family, cytosolic, 2B, member 1 | approved | Tamoxifen | ![]() | ![]() |
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Cross referenced IDs for SULT2B1 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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