Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for SULT2A1
Basic gene info.Gene symbolSULT2A1
Gene namesulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
SynonymsDHEA-ST|DHEAS|HST|ST2|ST2A1|ST2A3|STD|hSTa
CytomapUCSC genome browser: 19q13.3
Genomic locationchr19 :48373722-48389654
Type of geneprotein-coding
RefGenesNM_003167.3,
Ensembl idENSG00000105398
Descriptionalcohol/hydroxysteroid sulfotransferasebile salt sulfotransferasebile-salt sulfotranasferase 2A1
Modification date20141211
dbXrefs MIM : 125263
HGNC : HGNC
Ensembl : ENSG00000105398
HPRD : 00502
Vega : OTTHUMG00000162469
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SULT2A1
BioGPS: 6822
Gene Expression Atlas: ENSG00000105398
The Human Protein Atlas: ENSG00000105398
PathwayNCI Pathway Interaction Database: SULT2A1
KEGG: SULT2A1
REACTOME: SULT2A1
ConsensusPathDB
Pathway Commons: SULT2A1
MetabolismMetaCyc: SULT2A1
HUMANCyc: SULT2A1
RegulationEnsembl's Regulation: ENSG00000105398
miRBase: chr19 :48,373,722-48,389,654
TargetScan: NM_003167
cisRED: ENSG00000105398
ContextiHOP: SULT2A1
cancer metabolism search in PubMed: SULT2A1
UCL Cancer Institute: SULT2A1
Assigned class in ccmGDBC

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Phenotypic Information for SULT2A1(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: SULT2A1
Familial Cancer Database: SULT2A1
* This gene is included in those cancer gene databases.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: SULT2A1
MedGen: SULT2A1 (Human Medical Genetics with Condition)
ClinVar: SULT2A1
PhenotypeMGI: SULT2A1 (International Mouse Phenotyping Consortium)
PhenomicDB: SULT2A1

Mutations for SULT2A1
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows SULT2A1 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
AF130100SULT2A11167194837408648374252SERPINC115817081173872947173886473
AI110855SULT2A11167194837408648374252SERPINC11585911173883739173886473
AF075354SULT2A11167194837408648374252SERPINC11585911173883739173886473

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=4

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=35)
Stat. for Synonymous SNVs
(# total SNVs=15)
Stat. for Deletions
(# total SNVs=1)
Stat. for Insertions
(# total SNVs=0)
There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr19:48386910-48386910p.T90M3
chr19:48374745-48374745p.A275A2
chr19:48378071-48378071p.E196E2
chr19:48387023-48387023p.E52E2
chr19:48389467-48389467p.M16I2
chr19:48386926-48386926p.T85S2
chr19:48387042-48387042p.G46V2
chr19:48374808-48374808p.W254C2
chr19:48386958-48386958p.R74Q2
chr19:48377952-48377952p.V236A2

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=4

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample1  8  2 1  731  74 7
# mutation1  7  2 1  731  74 9
nonsynonymous SNV1  6  2    621  54 6
synonymous SNV   1    1  11   2  3
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr19:48386856p.S108Y3
chr19:48386910p.T85S2
chr19:48386926p.T90M2
chr19:48374808p.E196E1
chr19:48389466p.T85I1
chr19:48385411p.W7C1
chr19:48386976p.R193K1
chr19:48377943p.W7R1
chr19:48389471p.Q189H1
chr19:48385427p.R74Q1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for SULT2A1 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for SULT2A1

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

APCS,APOA1,APOA2,APOA4,APOC3,C8A,C9,
CREB3L3,CRP,F2,FABP1,FGF23,HP,ITIH1,
MT1B,PLG,SERPINA7,SERPINC1,SLC17A2,SULT2A1,TM4SF5
APOBEC1,B3GNT7,C17orf77,CYP2A13,DCAF12L2,ERBB2,GAL3ST2,
GIF,GPRC5A,HOXB13,JUP,KRT77,LINC01105,LOC400940,
LRRC59,PVALB,S100A7,S100A7A,S100P,SULT2A1,TSPAN8

AGMAT,APOC3,C1orf185,RIIAD1,CHEK2,CT47A1,DDC,
DRD1,MROH5,GCG,GGCT,HRSP12,ITGA2B,KIF6,
LGSN,NPHS2,SEPHS1,SH3GL2,SNAR-C4,SULT2A1,XAGE2
AADAC,APOA1,APOB,APOC3,CRISP1,FAM99A,FAM99B,
GSTA5,LCE3E,LOC388428,MOS,ONECUT3,OR10H1,OR10H5,
OR4N5,PWAR4___F2RL3___PAWR,SLC2A2,SLC5A12,SOAT2,SPANXN3,SULT2A1
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for SULT2A1
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB01708sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1nutraceuticalDehydroepiandrosterone
DB01812sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1experimentalAdenosine-3'-5'-Diphosphate
DB02854sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1experimentalAetiocholanolone
DB04445sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1experimentalMercury Diiodide
DB00988sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1approvedDopamine
DB00655sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1approvedEstrone
DB03255sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1experimentalPhenol
DB00783sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1approved; investigationalEstradiol
DB00675sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1approvedTamoxifen


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Cross referenced IDs for SULT2A1
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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