Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

Home

Search

Download

 Statistics

Help

About Us

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for ABCC8
Basic gene info.Gene symbolABCC8
Gene nameATP-binding cassette, sub-family C (CFTR/MRP), member 8
SynonymsABC36|HHF1|HI|HRINS|MRP8|PHHI|SUR|SUR1|SUR1delta2|TNDM2
CytomapUCSC genome browser: 11p15.1
Genomic locationchr11 :17414431-17498449
Type of geneprotein-coding
RefGenesNM_000352.4,
NM_001287174.1,
Ensembl idENSG00000006071
DescriptionATP-binding cassette sub-family C member 8ATP-binding cassette transporter sub-family C member 8sulfonylurea receptor (hyperinsulinemia)sulfonylurea receptor 1
Modification date20141222
dbXrefs MIM : 600509
HGNC : HGNC
Ensembl : ENSG00000006071
HPRD : 02741
Vega : OTTHUMG00000166316
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ABCC8
BioGPS: 6833
Gene Expression Atlas: ENSG00000006071
The Human Protein Atlas: ENSG00000006071
PathwayNCI Pathway Interaction Database: ABCC8
KEGG: ABCC8
REACTOME: ABCC8
ConsensusPathDB
Pathway Commons: ABCC8
MetabolismMetaCyc: ABCC8
HUMANCyc: ABCC8
RegulationEnsembl's Regulation: ENSG00000006071
miRBase: chr11 :17,414,431-17,498,449
TargetScan: NM_000352
cisRED: ENSG00000006071
ContextiHOP: ABCC8
cancer metabolism search in PubMed: ABCC8
UCL Cancer Institute: ABCC8
Assigned class in ccmGDBC

Top
Phenotypic Information for ABCC8(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: ABCC8
Familial Cancer Database: ABCC8
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
REACTOME_INTEGRATION_OF_ENERGY_METABOLISM

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: ABCC8
MedGen: ABCC8 (Human Medical Genetics with Condition)
ClinVar: ABCC8
PhenotypeMGI: ABCC8 (International Mouse Phenotyping Consortium)
PhenomicDB: ABCC8

Mutations for ABCC8
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram

- Statistics for Tissue and Mutation typeTop
- For Inter-chromosomal Variations
There's no inter-chromosomal structural variation.
- For Intra-chromosomal Variations
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'.
SampleSymbol_aChr_aStart_aEnd_aSymbol_bChr_bStart_bEnd_b
ovaryABCC8chr111745309717453117NCR3LG1chr111739132117391341
ovaryABCC8chr111745482417454844DLG2chr118381829083818310
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract)

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ABCC8 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
BF224199ABCC81151111741718517417468ABCC8149420111741846317418734

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

Top
check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
 
Mutation type/ Tissue IDbrcacnscervendomehaematopokidnLintestliverlungnsovarypancreprostskinstomathyrourina
Total # sample1     5 2        
GAIN (# sample)1       1        
LOSS (# sample)      5 1        
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

Top
check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=5

Top
check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=134)
Stat. for Synonymous SNVs
(# total SNVs=53)
Stat. for Deletions
(# total SNVs=2)
Stat. for Insertions
(# total SNVs=1)

Top
check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr11:17496474-17496474p.F83F4
chr11:17474774-17474774p.Y356Y3
chr11:17483345-17483345p.E203K3
chr11:17483288-17483288p.V222M3
chr11:17428206-17428206p.R1098C3
chr11:17418522-17418522p.D1354N3
chr11:17482058-17482058p.E330K3
chr11:17483187-17483187p.I255I3
chr11:17427081-17427081p.I1120N2
chr11:17449929-17449929p.K649N2

Top
check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=4

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample592241 14 4  231121 4718117
# mutation592271 13 4  261121 6521130
nonsynonymous SNV371161 10 4  2142  3411 20
synonymous SNV22112  3    57 1 3110110
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

Top
check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr11:17496474p.F83F,ABCC84
chr11:17434216p.F851F,ABCC83
chr11:17432122p.D424N,ABCC82
chr11:17418521p.I323I,ABCC82
chr11:17482077p.A1184A,ABCC82
chr11:17418522p.I250I,ABCC82
chr11:17436059p.R797L,ABCC82
chr11:17414607p.F1559F,ABCC82
chr11:17427072p.F1163F,ABCC82
chr11:17436131p.H1363H,ABCC82

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for ABCC8 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

Top
Gene Expression for ABCC8

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
Top
check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


Top
Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ABCC8,APH1B,ASTN2,CACNA1D,CACNA2D2,CYB5D2,DISP2,
EFCAB6,AMER3,FOXA1,KCNJ11,LOC283174,LRRC48,MAGI2,
MAPK8IP1,NOVA1,RPH3AL,SALL2,SPTBN4,TMEM145,TMEM63C
ABCC8,ASTN2,BATF,C9orf152,COL4A5,COL4A6,DNAJC12,
ETNK2,FAM81B,FOXL2,FTO,HMGCLL1,HS6ST2,KCNJ13,
LEO1,MUC6,PAFAH2,SERPINA5,TBC1D8,WIF1,ZNF689

ABCC8,AMBN,CA8,CACNA1S,CCDC83,CDKAL1,DHRS2,
EEF1DP3,FAM174B,FGF8,GFI1B,PTGDR2,IQCF2,IRGM,
PCDHB13,PCDHB15,PKD1L3,SEZ6L,TCHHL1,TCN1,TOX
ABCC8,CACNA1A,CDH22,AMER3,KCTD19,KIAA1467,FAR2P1,
MARCH4,PCSK1,PRB4,RIMBP2,RIMS2,SESN3,SLC18A1,
SLC7A2,ST18,TBX6,UCN3,UPK3A,VWA5B2,ZNF507
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

Top
check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

Top
Pharmacological Information for ABCC8
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB00171ATP-binding cassette, sub-family C (CFTR/MRP), member 8approved; nutraceuticalAdenosine triphosphate
DB00222ATP-binding cassette, sub-family C (CFTR/MRP), member 8approvedGlimepiride
DB00672ATP-binding cassette, sub-family C (CFTR/MRP), member 8approvedChlorpropamide
DB00731ATP-binding cassette, sub-family C (CFTR/MRP), member 8approved; investigationalNateglinide
DB00912ATP-binding cassette, sub-family C (CFTR/MRP), member 8approved; investigationalRepaglinide
DB01016ATP-binding cassette, sub-family C (CFTR/MRP), member 8approvedGlyburide
DB01067ATP-binding cassette, sub-family C (CFTR/MRP), member 8approvedGlipizide
DB01120ATP-binding cassette, sub-family C (CFTR/MRP), member 8approvedGliclazide
DB01124ATP-binding cassette, sub-family C (CFTR/MRP), member 8approvedTolbutamide
DB01251ATP-binding cassette, sub-family C (CFTR/MRP), member 8approvedGliquidone
DB01252ATP-binding cassette, sub-family C (CFTR/MRP), member 8approved; investigationalMitiglinide
DB01289ATP-binding cassette, sub-family C (CFTR/MRP), member 8approvedGlisoxepide
DB01382ATP-binding cassette, sub-family C (CFTR/MRP), member 8approvedGlycodiazine
DB01248ATP-binding cassette, sub-family C (CFTR/MRP), member 8approved; investigationalDocetaxel
DB00515ATP-binding cassette, sub-family C (CFTR/MRP), member 8approvedCisplatin
DB00441ATP-binding cassette, sub-family C (CFTR/MRP), member 8approvedGemcitabine
DB01119ATP-binding cassette, sub-family C (CFTR/MRP), member 8approvedDiazoxide


Top
Cross referenced IDs for ABCC8
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



Copyright © 2016-Present - The Univsersity of Texas Health Science Center at Houston @
Site Policies | State of Texas