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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for TAT |
Basic gene info. | Gene symbol | TAT |
Gene name | tyrosine aminotransferase | |
Synonyms | - | |
Cytomap | UCSC genome browser: 16q22.1 | |
Genomic location | chr16 :71600753-71610998 | |
Type of gene | protein-coding | |
RefGenes | NM_000353.2, | |
Ensembl id | ENSG00000198650 | |
Description | L-tyrosine:2-oxoglutarate aminotransferasetyrosine aminotransferase, cytosolic | |
Modification date | 20141207 | |
dbXrefs | MIM : 613018 | |
HGNC : HGNC | ||
HPRD : 11776 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TAT | |
BioGPS: 6898 | ||
Gene Expression Atlas: ENSG00000198650 | ||
The Human Protein Atlas: ENSG00000198650 | ||
Pathway | NCI Pathway Interaction Database: TAT | |
KEGG: TAT | ||
REACTOME: TAT | ||
ConsensusPathDB | ||
Pathway Commons: TAT | ||
Metabolism | MetaCyc: TAT | |
HUMANCyc: TAT | ||
Regulation | Ensembl's Regulation: ENSG00000198650 | |
miRBase: chr16 :71,600,753-71,610,998 | ||
TargetScan: NM_000353 | ||
cisRED: ENSG00000198650 | ||
Context | iHOP: TAT | |
cancer metabolism search in PubMed: TAT | ||
UCL Cancer Institute: TAT | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for TAT(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: TAT |
Familial Cancer Database: TAT |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
KEGG_CYSTEINE_AND_METHIONINE_METABOLISM KEGG_TYROSINE_METABOLISM KEGG_PHENYLALANINE_METABOLISM REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES |
Others | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: TAT |
MedGen: TAT (Human Medical Genetics with Condition) | |
ClinVar: TAT | |
Phenotype | MGI: TAT (International Mouse Phenotyping Consortium) |
PhenomicDB: TAT |
Mutations for TAT |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
There's no structural variation information in COSMIC data for this gene. |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows TAT related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
BG562569 | TAT | 1 | 339 | 16 | 71601286 | 71601625 | PPP2R1B | 333 | 781 | 11 | 111610550 | 111611006 |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
There's no copy number variation information in COSMIC data for this gene. |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=64) | (# total SNVs=17) |
(# total SNVs=0) | (# total SNVs=1) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr16:71610311-71610311 | p.P3L | 4 |
chr16:71603782-71603782 | p.R367H | 4 |
chr16:71604215-71604215 | p.R333H | 3 |
chr16:71602123-71602123 | p.A430V | 3 |
chr16:71604176-71604176 | p.L346R | 3 |
chr16:71602713-71602713 | p.? | 2 |
chr16:71609857-71609857 | p.S103L | 2 |
chr16:71604626-71604626 | p.G290C | 2 |
chr16:71606461-71606461 | p.G180E | 2 |
chr16:71610262-71610262 | p.D19D | 2 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 1 | 2 | 1 | 17 | 2 |   | 1 |   | 1 |   |   | 7 | 2 | 3 |   |   | 13 | 6 |   | 10 |
# mutation | 1 | 2 | 1 | 15 | 1 |   | 1 |   | 1 |   |   | 7 | 2 | 3 |   |   | 16 | 6 |   | 10 |
nonsynonymous SNV |   | 1 | 1 | 10 | 1 |   | 1 |   | 1 |   |   | 6 | 1 | 2 |   |   | 13 | 4 |   | 8 |
synonymous SNV | 1 | 1 |   | 5 |   |   |   |   |   |   |   | 1 | 1 | 1 |   |   | 3 | 2 |   | 2 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr16:71610311 | p.P3L | 4 |
chr16:71602123 | p.L346P | 3 |
chr16:71604176 | p.R333H | 3 |
chr16:71604215 | p.A430V | 3 |
chr16:71610209 | p.R367H | 2 |
chr16:71606176 | p.E207K | 2 |
chr16:71610262 | p.R37I | 2 |
chr16:71603782 | p.D19D | 2 |
chr16:71609830 | p.E248D | 1 |
chr16:71602173 | p.P81P | 1 |
Other DBs for Point Mutations |
Copy Number for TAT in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for TAT |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
C7orf34,CARTPT,CHGB,DCD,ENTPD5,FGF14,GLRA1, GPR26,GRIA3,KEL,LACRT,LRP2,OR9A2,PIP, SCG2,SLC5A8,SUSD4,TAT,TRPV5,UCP1,WT1 | ABAT,C9orf152,CANT1,CLGN,CT62,GLRA3,GREB1, ITIH6,MAGED2,MLPH,MYB,DNMBP-AS1,PRR15,SGK3, SLC39A6,TAT,TBC1D9,EWSAT1,TTC39A,XBP1,ZNF552 | ||||
ABCB11,C11orf86,CA2,CEACAM7,SLC52A1,GUCA2A,GUCA2B, KRT20,LDHD,MALL,MARVELD3,MEP1B,OTOP2,PTPRH, SLC17A4,SLC25A34,SLC30A10,SULT1A2,TAT,TMEM82,TMIGD1 | ABCB9,ABHD5,ACAP2,ACOX1,AQP8,CYP2B7P,ETFDH, ITCH,LANCL3,LOC25845,MIER3,NQO1,OSTalpha,RELL1, SLC20A1,SLC30A10,SLC9A3,TAT,TGFA,TMEM56,VDAC1 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for TAT |
Cross-referenced pharmacological DB IDs from Uniprot |
DB Category | DB Name | DB's ID and Url link |
Drug-Gene Interaction Network |
* Gene Centered Interaction Network. |
* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB00114 | tyrosine aminotransferase | nutraceutical | Pyridoxal Phosphate | ||
DB00120 | tyrosine aminotransferase | approved; nutraceutical | L-Phenylalanine | ||
DB00135 | tyrosine aminotransferase | approved; nutraceutical | L-Tyrosine | ||
DB00142 | tyrosine aminotransferase | approved; nutraceutical | L-Glutamic Acid | ||
DB04083 | tyrosine aminotransferase | experimental | N'-Pyridoxyl-Lysine-5'-Monophosphate | ||
DB00143 | tyrosine aminotransferase | approved; nutraceutical | Glutathione | ||
DB00360 | tyrosine aminotransferase | approved; investigational | Tetrahydrobiopterin | ||
DB01026 | tyrosine aminotransferase | approved; investigational | Ketoconazole | ||
DB01110 | tyrosine aminotransferase | approved; investigational | Miconazole |
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Cross referenced IDs for TAT |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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