Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

Home

Search

Download

 Statistics

Help

About Us

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for TEAD1
Basic gene info.Gene symbolTEAD1
Gene nameTEA domain family member 1 (SV40 transcriptional enhancer factor)
SynonymsAA|NTEF-1|REF1|TCF-13|TCF13|TEAD-1|TEF-1
CytomapUCSC genome browser: 11p15.2
Genomic locationchr11 :12695968-12966284
Type of geneprotein-coding
RefGenesNM_021961.5,
Ensembl idENSG00000187079
Descriptionprotein GT-IICtranscription factor 13transcriptional enhancer factor 1transcriptional enhancer factor TEF-1
Modification date20141207
dbXrefs MIM : 189967
HGNC : HGNC
Ensembl : ENSG00000187079
HPRD : 01802
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_TEAD1
BioGPS: 7003
Gene Expression Atlas: ENSG00000187079
The Human Protein Atlas: ENSG00000187079
PathwayNCI Pathway Interaction Database: TEAD1
KEGG: TEAD1
REACTOME: TEAD1
ConsensusPathDB
Pathway Commons: TEAD1
MetabolismMetaCyc: TEAD1
HUMANCyc: TEAD1
RegulationEnsembl's Regulation: ENSG00000187079
miRBase: chr11 :12,695,968-12,966,284
TargetScan: NM_021961
cisRED: ENSG00000187079
ContextiHOP: TEAD1
cancer metabolism search in PubMed: TEAD1
UCL Cancer Institute: TEAD1
Assigned class in ccmGDBC

Top
Phenotypic Information for TEAD1(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: TEAD1
Familial Cancer Database: TEAD1
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: TEAD1
MedGen: TEAD1 (Human Medical Genetics with Condition)
ClinVar: TEAD1
PhenotypeMGI: TEAD1 (International Mouse Phenotyping Consortium)
PhenomicDB: TEAD1

Mutations for TEAD1
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram

- Statistics for Tissue and Mutation typeTop
- For Inter-chromosomal Variations
* Inter-chromosomal variantions includes 'interchromosomal amplicon to amplicon', 'interchromosomal amplicon to non-amplified dna', 'interchromosomal insertion', 'Interchromosomal unknown type'.
- For Intra-chromosomal Variations
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'.
SampleSymbol_aChr_aStart_aEnd_aSymbol_bChr_bStart_bEnd_b
breastTEAD1chr111274129612741296TEAD1chr111284112612841126
ovaryTEAD1chr111273878212738802TEAD1chr111273886212738882
ovaryTEAD1chr111277422312774243GDPD4chr117692995776929977
pancreasTEAD1chr111294528812945308TEAD1chr111294820312948223
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract)

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows TEAD1 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
BF753132TEAD114128111296055912960678WDR4112524057673329076733405
AI126955SEMA6A11725115781820115781995TEAD1173507111269633912883832
BF990638C9709353930137839301401TEAD176476111296139112961792
BF353523TEAD113240111279904112799268TEAD1235389111279891912799073

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

Top
check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
 
Mutation type/ Tissue IDbrcacnscervendomehaematopokidnLintestliverlungnsovarypancreprostskinstomathyrourina
Total # sample41      2 1  1   
GAIN (# sample)3       2        
LOSS (# sample)11        1  1   
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

Top
check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=2

Top
check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=28)
Stat. for Synonymous SNVs
(# total SNVs=7)
Stat. for Deletions
(# total SNVs=0)
Stat. for Insertions
(# total SNVs=0)
There's no deleted snv.There's no inserted snv.

Top
check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr11:12901386-12901386p.P139P2
chr11:12946585-12946585p.V319L2
chr11:12886437-12886437p.S92C2
chr11:12901314-12901314p.I115I2
chr11:12901370-12901370p.T134I2
chr11:12951843-12951843p.N364N1
chr11:12883841-12883841p.K68Q1
chr11:12923582-12923582p.K250N1
chr11:12958659-12958659p.V376L1
chr11:12883843-12883843p.K68N1

Top
check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample2 142 2    41  123 4
# mutation2 142 2    41  123 4
nonsynonymous SNV1 132 2    31  111 2
synonymous SNV1  1       1    12 2
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

Top
check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr11:12901314p.I130I2
chr11:12958695p.E335Q1
chr11:12923582p.T149I1
chr11:12901332p.P357P1
chr11:12923603p.P154P1
chr11:12901370p.N379N1
chr11:12923629p.A179A1
chr11:12901386p.M403V1
chr11:12923642p.P191S1
chr11:12785940p.G208G1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for TEAD1 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

Top
Gene Expression for TEAD1

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
Top
check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


Top
Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ANO6,APC,BICC1,BMPR2,FER,LEPROT,LUZP1,
MAP3K2,MIB1,MYO9A,PARVA,PIK3C2A,PKD2,ROCK1,
SBF2,PEAK1,SH3D19,TCF12,TEAD1,TTBK2,ZNF699
ABCC9,ANKRD40,ANKRD46,GID4,DIAPH2,EIF4E3,FOXN3,
HSDL2,KIAA1715,MTMR10,PCYOX1,QKI,RDX,SAMD8,
SEC23A,SETD7,SGCB,SH3GLB1,TEAD1,YPEL2,YWHAG

ATXN1,BMPR2,CAMSAP2,DOK6,DSTYK,FTO,HIPK3,
JMY,KANK2,KIDINS220,LAMC1,MACF1,MAP1A,MBD5,
MKL2,PHF21A,PLEKHM3,SVIL,TEAD1,USP47,ZEB1
AKT3,AMOTL1,ANKS1B,BNC2,DIP2C,DMD,DOCK3,
FAM124A,FAM129A,GNAO1,NBEA,PCDH7,PPP1R12B,PRICKLE2,
RNF150,ROR2,SORBS1,SVIL,TEAD1,TNS1,TSHZ3
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

Top
check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

Top
Pharmacological Information for TEAD1


There's no related Drug.
Top
Cross referenced IDs for TEAD1
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



Copyright © 2016-Present - The Univsersity of Texas Health Science Center at Houston @
Site Policies | State of Texas