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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for TEAD3 |
Basic gene info. | Gene symbol | TEAD3 |
Gene name | TEA domain family member 3 | |
Synonyms | DTEF-1|ETFR-1|TEAD-3|TEAD5|TEF-5|TEF5 | |
Cytomap | UCSC genome browser: 6p21.2 | |
Genomic location | chr6 :35441373-35464861 | |
Type of gene | protein-coding | |
RefGenes | NM_003214.3, | |
Ensembl id | ENSG00000007866 | |
Description | TEA domain family member 5transcriptional enhancer factor 5transcriptional enhancer factor TEF-5transcriptional enhancer factor TEF-5 (DTEF-1) | |
Modification date | 20141207 | |
dbXrefs | MIM : 603170 | |
HGNC : HGNC | ||
Ensembl : ENSG00000007866 | ||
HPRD : 04411 | ||
Vega : OTTHUMG00000014571 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TEAD3 | |
BioGPS: 7005 | ||
Gene Expression Atlas: ENSG00000007866 | ||
The Human Protein Atlas: ENSG00000007866 | ||
Pathway | NCI Pathway Interaction Database: TEAD3 | |
KEGG: TEAD3 | ||
REACTOME: TEAD3 | ||
ConsensusPathDB | ||
Pathway Commons: TEAD3 | ||
Metabolism | MetaCyc: TEAD3 | |
HUMANCyc: TEAD3 | ||
Regulation | Ensembl's Regulation: ENSG00000007866 | |
miRBase: chr6 :35,441,373-35,464,861 | ||
TargetScan: NM_003214 | ||
cisRED: ENSG00000007866 | ||
Context | iHOP: TEAD3 | |
cancer metabolism search in PubMed: TEAD3 | ||
UCL Cancer Institute: TEAD3 | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for TEAD3(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: TEAD3 |
Familial Cancer Database: TEAD3 |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS |
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OMIM | |
Orphanet | |
Disease | KEGG Disease: TEAD3 |
MedGen: TEAD3 (Human Medical Genetics with Condition) | |
ClinVar: TEAD3 | |
Phenotype | MGI: TEAD3 (International Mouse Phenotyping Consortium) |
PhenomicDB: TEAD3 |
Mutations for TEAD3 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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- Statistics for Tissue and Mutation type | Top |
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- For Inter-chromosomal Variations |
There's no inter-chromosomal structural variation. |
- For Intra-chromosomal Variations |
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'. |
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Sample | Symbol_a | Chr_a | Start_a | End_a | Symbol_b | Chr_b | Start_b | End_b |
pancreas | TEAD3 | chr6 | 35441905 | 35441925 | TEAD3 | chr6 | 35441961 | 35441981 |
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract) |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows TEAD3 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
CF125399 | TEAD3 | 1 | 497 | 6 | 35441679 | 35464822 | TEAD3 | 490 | 723 | 6 | 35446079 | 35448150 | |
BE838173 | HDAC11 | 5 | 231 | 3 | 13545627 | 13546048 | TEAD3 | 226 | 363 | 6 | 35445131 | 35446279 |
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There's no copy number variation information in COSMIC data for this gene. |
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Stat. for Non-Synonymous SNVs (# total SNVs=22) | (# total SNVs=9) |
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(# total SNVs=1) | (# total SNVs=0) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr6:35443481-35443481 | p.A338A | 2 |
chr6:35442833-35442833 | p.L469L | 2 |
chr6:35446093-35446093 | p.S200S | 1 |
chr6:35442926-35442926 | p.T438T | 1 |
chr6:35454281-35454281 | p.C69C | 1 |
chr6:35444128-35444128 | p.R263Q | 1 |
chr6:35446212-35446212 | p.R197Q | 1 |
chr6:35443174-35443174 | p.L415P | 1 |
chr6:35454306-35454306 | p.E61V | 1 |
chr6:35444153-35444153 | p.R255C | 1 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 1 | 2 |   | 4 |   |   | 1 |   |   |   |   | 4 |   | 1 |   | 1 | 3 | 3 |   | 5 |
# mutation | 1 | 3 |   | 4 |   |   | 1 |   |   |   |   | 5 |   | 1 |   | 1 | 3 | 2 |   | 5 |
nonsynonymous SNV | 1 | 1 |   | 3 |   |   |   |   |   |   |   | 4 |   | 1 |   | 1 | 1 |   |   | 4 |
synonymous SNV |   | 2 |   | 1 |   |   | 1 |   |   |   |   | 1 |   |   |   |   | 2 | 2 |   | 1 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr6:35443481 | p.A301A | 2 |
chr6:35444194 | p.P204Q | 2 |
chr6:35454306 | p.G356W | 1 |
chr6:35443241 | p.R160Q | 1 |
chr6:35445110 | p.V331V | 1 |
chr6:35454315 | p.L150L | 1 |
chr6:35443391 | p.D325N | 1 |
chr6:35446053 | p.R103W | 1 |
chr6:35454350 | p.E63Q | 1 |
chr6:35443411 | p.F299L | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for TEAD3 |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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AARS2,ABT1,DDX39B,BAG6,C6orf47,DXO,EHMT2, FANCE,GTF2H4,LEMD2,LY6G5B,PBX2,PPARD,PPP1R13L, PTK7,RXRB,SMTN,TAF11,TCF3,TEAD3,ZNF76 | ARVCF,C17orf107,CADM4,CARD14,CDC42BPG,CIC,DAB2IP, DDR1,EPS8L2,FAM129B,HS6ST1,ITGB4,LMX1B,MARK2, PLCH2,PPP1R13L,SH2D3A,SLC4A3,TEAD3,TNK1,TRIM26 |
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TMEM240,C6orf106,C6orf89,DACT3,FOXP4,ITGA7,KANK2, LOC728264,MRVI1,MYL9,PHF1,SPEG,SYPL2,TCF7L1, TEAD3,TGFB1I1,TMEM200B,TNS1,TPM2,TRIM39,ZFAND3 | ACTN1,AOC3,ATP2B4,BVES,CACNA1C,CACNA1H,CALD1, CPXM2,FLNA,KCNH2,LDB3,MPP2,NPTXR,NRXN2, PDLIM7,SMTN,SPEG,TACR2,TEAD3,TGFB1I1,TNS1 |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for TEAD3 |
There's no related Drug. |
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Cross referenced IDs for TEAD3 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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