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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for TST |
Basic gene info. | Gene symbol | TST |
Gene name | thiosulfate sulfurtransferase (rhodanese) | |
Synonyms | RDS | |
Cytomap | UCSC genome browser: 22q13.1 | |
Genomic location | chr22 :37406905-37415491 | |
Type of gene | protein-coding | |
RefGenes | NM_001270483.1, NM_003312.5, | |
Ensembl id | ENSG00000128311 | |
Description | thiosulfate sulfurtransferase | |
Modification date | 20141216 | |
dbXrefs | MIM : 180370 | |
HGNC : HGNC | ||
Ensembl : ENSG00000128311 | ||
HPRD : 01583 | ||
Vega : OTTHUMG00000150533 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TST | |
BioGPS: 7263 | ||
Gene Expression Atlas: ENSG00000128311 | ||
The Human Protein Atlas: ENSG00000128311 | ||
Pathway | NCI Pathway Interaction Database: TST | |
KEGG: TST | ||
REACTOME: TST | ||
ConsensusPathDB | ||
Pathway Commons: TST | ||
Metabolism | MetaCyc: TST | |
HUMANCyc: TST | ||
Regulation | Ensembl's Regulation: ENSG00000128311 | |
miRBase: chr22 :37,406,905-37,415,491 | ||
TargetScan: NM_001270483 | ||
cisRED: ENSG00000128311 | ||
Context | iHOP: TST | |
cancer metabolism search in PubMed: TST | ||
UCL Cancer Institute: TST | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for TST(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: TST |
Familial Cancer Database: TST |
* This gene is included in those cancer gene databases. |
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
REACTOME_SULFUR_AMINO_ACID_METABOLISM REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES |
Others | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: TST |
MedGen: TST (Human Medical Genetics with Condition) | |
ClinVar: TST | |
Phenotype | MGI: TST (International Mouse Phenotyping Consortium) |
PhenomicDB: TST |
Mutations for TST |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
There's no structural variation information in COSMIC data for this gene. |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows TST related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
Mutation type/ Tissue ID | brca | cns | cerv | endome | haematopo | kidn | Lintest | liver | lung | ns | ovary | pancre | prost | skin | stoma | thyro | urina | |||
Total # sample |   |   |   |   |   |   |   |   | 1 |   |   |   |   |   |   |   |   | |||
GAIN (# sample) |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   | |||
LOSS (# sample) |   |   |   |   |   |   |   |   | 1 |   |   |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract) |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=25) | (# total SNVs=0) |
(# total SNVs=0) | (# total SNVs=0) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr22:37407092-37407092 | p.S290S | 2 |
chr22:37407135-37407135 | p.W276L | 2 |
chr22:37414224-37414224 | p.S184P | 2 |
chr22:37414262-37414262 | p.N171T | 2 |
chr22:37414702-37414702 | p.K24K | 1 |
chr22:37407193-37407193 | p.V257M | 1 |
chr22:37414285-37414285 | p.K163N | 1 |
chr22:37414749-37414749 | p.A9S | 1 |
chr22:37407215-37407215 | p.R249R | 1 |
chr22:37414320-37414320 | p.V152I | 1 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 1 |   | 1 | 1 |   |   | 3 |   | 1 |   |   | 1 | 1 |   |   |   | 5 |   |   | 4 |
# mutation | 1 |   | 1 | 1 |   |   | 3 |   | 1 |   |   | 1 | 1 |   |   |   | 5 |   |   | 4 |
nonsynonymous SNV |   |   | 1 | 1 |   |   | 2 |   | 1 |   |   | 1 | 1 |   |   |   | 2 |   |   | 4 |
synonymous SNV | 1 |   |   |   |   |   | 1 |   |   |   |   |   |   |   |   |   | 3 |   |   |   |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr22:37407092 | p.S290S,TST | 2 |
chr22:37407100 | p.R288C,TST | 2 |
chr22:37407247 | p.S143S,TST | 1 |
chr22:37407254 | p.F107L,TST | 1 |
chr22:37414210 | p.D66Y,TST | 1 |
chr22:37414320 | p.D60H,TST | 1 |
chr22:37407110 | p.K24K,TST | 1 |
chr22:37414345 | p.P284P,TST | 1 |
chr22:37407115 | p.A283P,TST | 1 |
chr22:37414453 | p.R281S,TST | 1 |
Other DBs for Point Mutations |
Copy Number for TST in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for TST |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
ADCK5,HGH1,COMMD5,CYC1,DGAT1,EEF1D,EXOSC4, FBXL6,GPAA1,SLC52A2,GUK1,LYPLA2,MAF1,NAPRT, PUF60,PYCRL,RPL8,SHARPIN,TIGD5,TSTA3,VPS28 | AP1S1,EMC10,CDK5,CHPF,CORO1B,DAK,DPP3, ECE2,LMAN2,MAEA,MBOAT7,MCAT,MIF,NANS, NHP2,PHB,SDSL,SLC25A39,TIMM13,TMEM132A,TSTA3 | ||||
ADAM15,AGR2,AGR3,AKR7A3,BACE2,HID1,SLC18B1, COQ4,DAD1,GSDMD,GUK1,JTB,NAPRT,OSR2, S100P,SDR16C5,SOD1,TSTA3,UAP1,UBXN8,VPS28 | C19orf10,C4BPB,CD164L2,CRELD2,GNA15,INSL4,KDELR3, LILRA3,MANF,MMP1,MMP3,MTHFD2,PDIA6,PGM3, PPIB,PRSS22,SLC50A1,RPL22L1,S100A11,SLC6A14,TSTA3 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for TST |
Cross-referenced pharmacological DB IDs from Uniprot |
DB Category | DB Name | DB's ID and Url link |
Drug-Gene Interaction Network |
* Gene Centered Interaction Network. |
* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB04053 | thiosulfate sulfurtransferase (rhodanese) | experimental | Hypophosphite | ||
DB02761 | thiosulfate sulfurtransferase (rhodanese) | experimental | S-Mercaptocysteine |
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Cross referenced IDs for TST |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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