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| Phenotypic Information (metabolism pathway, cancer, disease, phenome) |
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| Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG |
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| Gene Summary for TXN |
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| Phenotypic Information for TXN(metabolism pathway, cancer, disease, phenome) |
 Cancer Description | |
| Cancer | CGAP: TXN |
| Familial Cancer Database: TXN | |
| * This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in | |||||||||||||||||||
| cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
| Metabolic Pathway Description | |
| REACTOME_METABOLISM_OF_NUCLEOTIDES | |
| Others | |
| OMIM | |
| Orphanet | |
| Disease | KEGG Disease: TXN |
| MedGen: TXN (Human Medical Genetics with Condition) | |
| ClinVar: TXN | |
| Phenotype | MGI: TXN (International Mouse Phenotyping Consortium) |
| PhenomicDB: TXN | |
| Mutations for TXN |
| * Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
| Structural Variants in COSMIC: go to COSMIC mutation histogram |
| There's no structural variation information in COSMIC data for this gene. |
| Related fusion transcripts : go to Chitars2.0 |
| * From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows TXN related fusion information. |
| ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
| AA362147 | TXN | 1 | 293 | 9 | 113007068 | 113018762 | IL1B | 288 | 366 | 2 | 113587565 | 113587644 | |
| D58281 | LATS2 | 1 | 210 | 13 | 21547175 | 21547384 | TXN | 210 | 431 | 9 | 113006300 | 113007080 | |
| Other DBs for Structural Variants |
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| Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
| There's no copy number variation information in COSMIC data for this gene. |
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| SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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: Non-synonymous mutation, 
: Synonymous mutation, Circle size denotes number of samples. |
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| Somatic Mutation Counts per Tissue in COSMIC data |
| Stat. for Non-Synonymous SNVs (# total SNVs=3) | (# total SNVs=2) |
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(# total SNVs=0) | (# total SNVs=0) |
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| Top 10 SNVs Having the Most Samples in COSMIC data |
| * When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
| GRCh37 position | Mutation(aa) | Unique sampleID count |
| chr9:113006463-113006463 | p.E98K | 1 |
| chr9:113007067-113007067 | p.K82N | 1 |
| chr9:113007124-113007124 | p.? | 1 |
| chr9:113013637-113013637 | p.? | 1 |
| chr9:113013686-113013686 | p.F27F | 1 |
| chr9:113013693-113013693 | p.V25A | 1 |
| chr9:113013695-113013695 | p.V24V | 1 |
| chr9:113013721-113013721 | p.D16N | 1 |
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| SNV Counts per Each Loci in TCGA data |
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| Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
| # sample | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||||||||
| # mutation | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||||||||
| nonsynonymous SNV | 1 | 1 | 1 | 1 | ||||||||||||||||
| synonymous SNV | 1 | 1 |
| cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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| Top 10 SNVs Having the Most Samples in TCGA data |
| * We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
| Genomic Position | Mutation(aa) | Unique sampleID count |
| chr9:113006463 | p.E78K,TXN | 1 |
| chr9:113007067 | p.K62N,TXN | 1 |
| chr9:113013678 | p.T30M,TXN | 1 |
| chr9:113013686 | p.F27F,TXN | 1 |
| chr9:113013693 | p.V25G,TXN | 1 |
| chr9:113013695 | p.V24V,TXN | 1 |
| Other DBs for Point Mutations |
| Copy Number for TXN in TCGA |
| * Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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| cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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| Gene Expression for TXN |
| Gene Expression in Cancer Cell-lines (CCLE) |
| * CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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| Differential Gene Expression in Primary Tumors (TCGA) |
| * Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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| CNV vs Gene Expression Plot |
| * This plots show the correlation between CNV and gene expression. |
: Open all plots for all cancer types
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| Gene-Gene Network Information |
| Co-Expressed gene's network Plot |
| * Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
: Open all plots for all cancer types
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| ALKBH7,LAMTOR4,CHCHD5,COMT,DGCR6,DGCR6L,DHRS4, FBXL15,FIS1,KLHL22,MRPL53,NAGLU,PHPT1,RPS19BP1, SDSL,SELO,THAP7,TIMM13,TRMT2A,TSSC4,TXNRD2 | ANAPC2,APBA3,VPS9D1,CCDC22,CPSF3L,DUS1L,E4F1, GGA1,LRSAM1,NARFL,OGFOD2,PNKP,RABEP2,RHOT2, RPS6KB2,SELO,TBL3,TMED1,TUT1,TXNRD2,ZBTB17 | ||||
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| ALG12,BRF1,CECR5,DGCR14,DGCR6L,GGA1,MCAT, PES1,PICK1,PPIL2,RANGAP1,RHBDD3,RPS19BP1,SLC25A1, SMARCB1,SNRPD3,TAB1,THAP7,TRMT2A,TXNRD2,YDJC | BTBD2,VPS51___IFT46,THEM6,CCDC61,DDX41,DPH1,MACROD1, MAZ,MRPS2,PEX10,PRMT7,QARS,QTRT1,RPS2, RPUSD1,SLC25A6,SPNS1,STK11,THAP4,TXNRD2,ZNF414 |
| Co-Expressed gene's Protein-protein interaction Network Plot |
| * Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
: Open all plots for all cancer types
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| Interacting Genes (from Pathway Commons) |
: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID
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| Pharmacological Information for TXN |
| Cross-referenced pharmacological DB IDs from Uniprot |
| DB Category | DB Name | DB's ID and Url link |
| Drug-Gene Interaction Network |
| * Gene Centered Interaction Network. |
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| * Drug Centered Interaction Network. |
| DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
| DB00130 | thioredoxin | approved; nutraceutical; investigational | L-Glutamine |  |  |
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| Cross referenced IDs for TXN |
| * We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
: Open all cross reference information
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