Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

Home

Search

Download

 Statistics

Help

About Us

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for UGT2B10
Basic gene info.Gene symbolUGT2B10
Gene nameUDP glucuronosyltransferase 2 family, polypeptide B10
SynonymsUDPGT2B10
CytomapUCSC genome browser: 4q13.2
Genomic locationchr4_ctg9_hap1 :393963-409992
Type of geneprotein-coding
RefGenesNM_001075.5,
NM_001144767.2,NM_001290091.1,
Ensembl idENSG00000109181
DescriptionUDP-glucuronosyltransferase 2B10UDPGT 2B10
Modification date20141207
dbXrefs MIM : 600070
HGNC : HGNC
HPRD : 07193
ProteinUniProt: P36537
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_UGT2B10
BioGPS: 7365
Gene Expression Atlas: ENSG00000109181
The Human Protein Atlas: ENSG00000109181
PathwayNCI Pathway Interaction Database: UGT2B10
KEGG: UGT2B10
REACTOME: UGT2B10
ConsensusPathDB
Pathway Commons: UGT2B10
MetabolismMetaCyc: UGT2B10
HUMANCyc: UGT2B10
RegulationEnsembl's Regulation: ENSG00000109181
miRBase: chr4_ctg9_hap1 :393,963-409,992
TargetScan: NM_001075
cisRED: ENSG00000109181
ContextiHOP: UGT2B10
cancer metabolism search in PubMed: UGT2B10
UCL Cancer Institute: UGT2B10
Assigned class in ccmGDBA - This gene has a literature evidence and it belongs to cancer gene.
References showing role of UGT2B10 in cancer cell metabolism1. Wassenaar CA, Conti DV, Das S, Chen P, Cook EH, et al. (2015) UGT1A and UGT2B genetic variation alters nicotine and nitrosamine glucuronidation in European and African American smokers. Cancer Epidemiology Biomarkers & Prevention 24: 94-104. go to article
2. Patel YM, Stram DO, Wilkens LR, Park S-SL, Henderson BE, et al. (2015) The Contribution of Common Genetic Variation to Nicotine and Cotinine Glucuronidation in Multiple Ethnic/Racial Populations. Cancer Epidemiology Biomarkers & Prevention 24: 119-127. go to article

Top
Phenotypic Information for UGT2B10(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: UGT2B10
Familial Cancer Database: UGT2B10
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_ASCORBATE_AND_ALDARATE_METABOLISM
KEGG_STARCH_AND_SUCROSE_METABOLISM
KEGG_RETINOL_METABOLISM
KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM
KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450
KEGG_DRUG_METABOLISM_CYTOCHROME_P450
KEGG_DRUG_METABOLISM_OTHER_ENZYMES

check002.gifOthers
OMIM 600070; gene.
Orphanet
DiseaseKEGG Disease: UGT2B10
MedGen: UGT2B10 (Human Medical Genetics with Condition)
ClinVar: UGT2B10
PhenotypeMGI: UGT2B10 (International Mouse Phenotyping Consortium)
PhenomicDB: UGT2B10

Mutations for UGT2B10
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows UGT2B10 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
BP239062SLC16A112511113456386113456634UGT2B1025259646968171369688006

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

Top
check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

Top
check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=3

Top
check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=58)
Stat. for Synonymous SNVs
(# total SNVs=15)
Stat. for Deletions
(# total SNVs=1)
Stat. for Insertions
(# total SNVs=0)
There's no inserted snv.

Top
check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr4:69693266-69693266p.S436L3
chr4:69683824-69683824p.P266S3
chr4:69681921-69681921p.L62I3
chr4:69681805-69681805p.G23E2
chr4:69682288-69682288p.G184V2
chr4:69682129-69682129p.S131L2
chr4:69681841-69681841p.W35*2
chr4:69693267-69693267p.?2
chr4:69681966-69681966p.P77T2
chr4:69692138-69692138p.R337K2

Top
check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=3

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample12215 7 51 1332 2318 14
# mutation12215 8 51 1632 2389 19
nonsynonymous SNV 2213 8 3  1431 1296 18
synonymous SNV1   2   21 2 1 193 1
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

Top
check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr4:69683824p.D434Y,UGT2B103
chr4:69681921p.L62I,UGT2B103
chr4:69870721p.R10L3
chr4:69884051p.H232H3
chr4:69693259p.P266S,UGT2B103
chr4:69681805p.S436L,UGT2B102
chr4:69681966p.P77T,UGT2B102
chr4:69696437p.G525V,UGT2B102
chr4:69696584p.R476L,UGT2B102
chr4:69870734p.G23E,UGT2B102

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for UGT2B10 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

Top
Gene Expression for UGT2B10

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
Top
check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


Top
Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ACSM1,CT45A1,CT45A3,FRG2B,GGT1,GGT3P,HGC6.3,
MAGEA8,MAGEB18,RPL3L,SCP2,SPPL2A,TAAR6,TYRP1,
UGT2B10,UGT2B11,UGT2B15,UGT2B28,UGT2B7,USP29,ZIM3
ACSL3,ADAM2,AFMID,ALOX15B,DHRS2,HIST1H4H,HPGD,
HSD3B2,IDI1,LST-3TM12,MPV17L,PNLIPRP3,PPEF1,SERHL2,
SERHL,SPINK8,SRD5A1,SULT1C3,UGT2B10,UGT2B11,UGT2B28

CHRNA2,CYLC1,GAD2,GPR83,KCTD16,KRT36,KRT38,
LCN10,MYCN,MYCNOS,MYL3,NNAT,SCARNA20,SPTLC3,
TGM5,UGT2A3,UGT2B10,UGT2B11,UGT2B28,UGT2B7,UNC13C
AMBP,APOH,CD164,CDKN2B-AS1,FAM177A1,GALNT12,HS3ST6,
IP6K2,KLHL12,MINPP1,MMP28,NHEJ1,PNKD,RAB37,
S100A10,SLCO1B1,SLCO6A1,SYTL2,TBC1D10A,TMCO1,UGT2B10
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

Top
check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

Top
Pharmacological Information for UGT2B10
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link
ChemistryChEMBL CHEMBL6160; -.
Organism-specific databasesPharmGKB PA37186; -.
Organism-specific databasesCTD 7365; -.

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB00184UDP glucuronosyltransferase 2 family, polypeptide B10approvedNicotine


Top
Cross referenced IDs for UGT2B10
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



Copyright © 2016-Present - The Univsersity of Texas Health Science Center at Houston @
Site Policies | State of Texas