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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for UGT2B15 |
Basic gene info. | Gene symbol | UGT2B15 |
Gene name | UDP glucuronosyltransferase 2 family, polypeptide B15 | |
Synonyms | HLUG4|UDPGT 2B8|UDPGT2B15|UDPGTH3|UGT2B8 | |
Cytomap | UCSC genome browser: 4q13 | |
Genomic location | chr4_ctg9_hap1 :224913-249081 | |
Type of gene | protein-coding | |
RefGenes | NM_001076.3, | |
Ensembl id | ENSG00000196620 | |
Description | UDP glycosyltransferase 2B15UDP-glucuronosyltransferase 2B15UDP-glucuronosyltransferase 2B8UDP-glucuronosyltransferase UGT2B15UDP-glucuronyltransferase, family 2, beta-15UDPGT 2B15UDPGTh-3 | |
Modification date | 20141207 | |
dbXrefs | MIM : 600069 | |
HGNC : HGNC | ||
Ensembl : ENSG00000196620 | ||
HPRD : 07192 | ||
Vega : OTTHUMG00000161507 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_UGT2B15 | |
BioGPS: 7366 | ||
Gene Expression Atlas: ENSG00000196620 | ||
The Human Protein Atlas: ENSG00000196620 | ||
Pathway | NCI Pathway Interaction Database: UGT2B15 | |
KEGG: UGT2B15 | ||
REACTOME: UGT2B15 | ||
ConsensusPathDB | ||
Pathway Commons: UGT2B15 | ||
Metabolism | MetaCyc: UGT2B15 | |
HUMANCyc: UGT2B15 | ||
Regulation | Ensembl's Regulation: ENSG00000196620 | |
miRBase: chr4_ctg9_hap1 :224,913-249,081 | ||
TargetScan: NM_001076 | ||
cisRED: ENSG00000196620 | ||
Context | iHOP: UGT2B15 | |
cancer metabolism search in PubMed: UGT2B15 | ||
UCL Cancer Institute: UGT2B15 | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for UGT2B15(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: UGT2B15 |
Familial Cancer Database: UGT2B15 |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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KEGG_ASCORBATE_AND_ALDARATE_METABOLISM KEGG_STARCH_AND_SUCROSE_METABOLISM KEGG_RETINOL_METABOLISM KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 KEGG_DRUG_METABOLISM_CYTOCHROME_P450 KEGG_DRUG_METABOLISM_OTHER_ENZYMES |
Mutations for UGT2B15 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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There's no structural variation information in COSMIC data for this gene. |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows UGT2B15 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
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There's no copy number variation information in COSMIC data for this gene. |
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Stat. for Non-Synonymous SNVs (# total SNVs=1) | (# total SNVs=0) |
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(# total SNVs=0) | (# total SNVs=0) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr4:69563451-69563451 | p.E295D | 1 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample |   | 3 | 1 | 1 | 1 |   | 4 |   | 1 |   |   | 13 | 4 |   |   |   | 24 | 3 |   | 13 |
# mutation |   | 3 | 1 | 1 | 1 |   | 4 |   | 1 |   |   | 12 | 4 |   |   |   | 33 | 3 |   | 12 |
nonsynonymous SNV |   | 2 | 1 | 1 | 1 |   | 2 |   | 1 |   |   | 7 | 3 |   |   |   | 22 | 2 |   | 8 |
synonymous SNV |   | 1 |   |   |   |   | 2 |   |   |   |   | 5 | 1 |   |   |   | 11 | 1 |   | 4 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr4:69519925 | p.I381I | 3 |
chr4:69536055 | p.M215I | 2 |
chr4:69535816 | p.L94L | 2 |
chr4:69513061 | p.R174Q | 2 |
chr4:69535692 | p.L3L | 2 |
chr4:69536328 | p.D452N | 2 |
chr4:69536035 | p.R448I | 1 |
chr4:69533901 | p.L219I | 1 |
chr4:69512998 | p.V101A | 1 |
chr4:69519807 | p.E441D | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for UGT2B15 |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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AP3M1,BAG5,BEST3,METTL25,CA2,FAM9A,FRG2B, LEO1,OR10J5,RPL3L,SPPL2A,TFF1,TRH,TSG1, TYRP1,UGT2B10,UGT2B11,UGT2B15,USP29,USP8,VSIG1 | ALB,ANGPTL3,ANKFN1,BCO1,HNF1A-AS1,SMCO3,C5, FGL1,HABP2,HNF1A,IGFL2,KIF12,MIA2,MTNR1B, PKHD1,RHBG,SERPINA4,TMED6,TTLL6,UGT2B15,ZNF385B | ||||
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ADH1C,AMPD1,B3GALT1,ADTRP,CA2,CA4,CASR, CEACAM7,GPR15,GUCA2A,HSD3B2,ITM2C,LDHD,MS4A12, NR3C2,PIGR,SCNN1B,SLC25A34,TMIGD1,UGT2B15,USP2 | ACCSL,AGGF1,CDH20,CNOT6L,FMR1,IFNAR1,IL13RA1, IREB2,KDM3A,LOC148824,LRRC6,MAN1A1,PTEN,TLR3, TMEM229B,TSGA10IP,UGT2B15,VCPIP1,ZHX1,ZNF217,ZNF654 |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for UGT2B15 |
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DB Category | DB Name | DB's ID and Url link |
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* Gene Centered Interaction Network. |
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* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB00675 | UDP glucuronosyltransferase 2 family, polypeptide B15 | approved | Tamoxifen | ![]() | ![]() |
DB00842 | UDP glucuronosyltransferase 2 family, polypeptide B15 | approved | Oxazepam | ![]() | ![]() |
DB00973 | UDP glucuronosyltransferase 2 family, polypeptide B15 | approved | Ezetimibe | ![]() | ![]() |
DB00184 | UDP glucuronosyltransferase 2 family, polypeptide B15 | approved | Nicotine | ![]() | ![]() |
DB00313 | UDP glucuronosyltransferase 2 family, polypeptide B15 | approved; investigational | Valproic Acid | ![]() | ![]() |
DB00186 | UDP glucuronosyltransferase 2 family, polypeptide B15 | approved | Lorazepam | ![]() | ![]() |
DB01033 | UDP glucuronosyltransferase 2 family, polypeptide B15 | approved | Mercaptopurine | ![]() | ![]() |
DB00563 | UDP glucuronosyltransferase 2 family, polypeptide B15 | approved | Methotrexate | ![]() | ![]() |
DB00890 | UDP glucuronosyltransferase 2 family, polypeptide B15 | approved | Dienestrol | ![]() | ![]() |
DB00252 | UDP glucuronosyltransferase 2 family, polypeptide B15 | approved | Phenytoin | ![]() | ![]() |
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Cross referenced IDs for UGT2B15 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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