Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for UGT2B15
Basic gene info.Gene symbolUGT2B15
Gene nameUDP glucuronosyltransferase 2 family, polypeptide B15
SynonymsHLUG4|UDPGT 2B8|UDPGT2B15|UDPGTH3|UGT2B8
CytomapUCSC genome browser: 4q13
Genomic locationchr4_ctg9_hap1 :224913-249081
Type of geneprotein-coding
RefGenesNM_001076.3,
Ensembl idENSG00000196620
DescriptionUDP glycosyltransferase 2B15UDP-glucuronosyltransferase 2B15UDP-glucuronosyltransferase 2B8UDP-glucuronosyltransferase UGT2B15UDP-glucuronyltransferase, family 2, beta-15UDPGT 2B15UDPGTh-3
Modification date20141207
dbXrefs MIM : 600069
HGNC : HGNC
Ensembl : ENSG00000196620
HPRD : 07192
Vega : OTTHUMG00000161507
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_UGT2B15
BioGPS: 7366
Gene Expression Atlas: ENSG00000196620
The Human Protein Atlas: ENSG00000196620
PathwayNCI Pathway Interaction Database: UGT2B15
KEGG: UGT2B15
REACTOME: UGT2B15
ConsensusPathDB
Pathway Commons: UGT2B15
MetabolismMetaCyc: UGT2B15
HUMANCyc: UGT2B15
RegulationEnsembl's Regulation: ENSG00000196620
miRBase: chr4_ctg9_hap1 :224,913-249,081
TargetScan: NM_001076
cisRED: ENSG00000196620
ContextiHOP: UGT2B15
cancer metabolism search in PubMed: UGT2B15
UCL Cancer Institute: UGT2B15
Assigned class in ccmGDBC

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Phenotypic Information for UGT2B15(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: UGT2B15
Familial Cancer Database: UGT2B15
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_ASCORBATE_AND_ALDARATE_METABOLISM
KEGG_STARCH_AND_SUCROSE_METABOLISM
KEGG_RETINOL_METABOLISM
KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM
KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450
KEGG_DRUG_METABOLISM_CYTOCHROME_P450
KEGG_DRUG_METABOLISM_OTHER_ENZYMES

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: UGT2B15
MedGen: UGT2B15 (Human Medical Genetics with Condition)
ClinVar: UGT2B15
PhenotypeMGI: UGT2B15 (International Mouse Phenotyping Consortium)
PhenomicDB: UGT2B15

Mutations for UGT2B15
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows UGT2B15 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=1

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=1)
Stat. for Synonymous SNVs
(# total SNVs=0)
There's no s-snv.
Stat. for Deletions
(# total SNVs=0)
Stat. for Insertions
(# total SNVs=0)
There's no deleted snv.There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr4:69563451-69563451p.E295D1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=3

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample 3111 4 1  134   243 13
# mutation 3111 4 1  124   333 12
nonsynonymous SNV 2111 2 1  73   222 8
synonymous SNV 1    2    51   111 4
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr4:69519925p.I381I3
chr4:69536328p.L3L2
chr4:69536055p.D452N2
chr4:69535816p.M215I2
chr4:69513061p.L94L2
chr4:69535692p.R174Q2
chr4:69535920p.F248L1
chr4:69519874p.L170L1
chr4:69536220p.L11L1
chr4:69512912p.I487I1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for UGT2B15 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for UGT2B15

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

AP3M1,BAG5,BEST3,METTL25,CA2,FAM9A,FRG2B,
LEO1,OR10J5,RPL3L,SPPL2A,TFF1,TRH,TSG1,
TYRP1,UGT2B10,UGT2B11,UGT2B15,USP29,USP8,VSIG1
ALB,ANGPTL3,ANKFN1,BCO1,HNF1A-AS1,SMCO3,C5,
FGL1,HABP2,HNF1A,IGFL2,KIF12,MIA2,MTNR1B,
PKHD1,RHBG,SERPINA4,TMED6,TTLL6,UGT2B15,ZNF385B

ADH1C,AMPD1,B3GALT1,ADTRP,CA2,CA4,CASR,
CEACAM7,GPR15,GUCA2A,HSD3B2,ITM2C,LDHD,MS4A12,
NR3C2,PIGR,SCNN1B,SLC25A34,TMIGD1,UGT2B15,USP2
ACCSL,AGGF1,CDH20,CNOT6L,FMR1,IFNAR1,IL13RA1,
IREB2,KDM3A,LOC148824,LRRC6,MAN1A1,PTEN,TLR3,
TMEM229B,TSGA10IP,UGT2B15,VCPIP1,ZHX1,ZNF217,ZNF654
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for UGT2B15
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB00675UDP glucuronosyltransferase 2 family, polypeptide B15approvedTamoxifen
DB00842UDP glucuronosyltransferase 2 family, polypeptide B15approvedOxazepam
DB00973UDP glucuronosyltransferase 2 family, polypeptide B15approvedEzetimibe
DB00184UDP glucuronosyltransferase 2 family, polypeptide B15approvedNicotine
DB00313UDP glucuronosyltransferase 2 family, polypeptide B15approved; investigationalValproic Acid
DB00186UDP glucuronosyltransferase 2 family, polypeptide B15approvedLorazepam
DB01033UDP glucuronosyltransferase 2 family, polypeptide B15approvedMercaptopurine
DB00563UDP glucuronosyltransferase 2 family, polypeptide B15approvedMethotrexate
DB00890UDP glucuronosyltransferase 2 family, polypeptide B15approvedDienestrol
DB00252UDP glucuronosyltransferase 2 family, polypeptide B15approvedPhenytoin


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Cross referenced IDs for UGT2B15
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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