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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for YWHAZ |
Basic gene info. | Gene symbol | YWHAZ |
Gene name | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | |
Synonyms | 14-3-3-zeta|HEL-S-3|HEL4|KCIP-1|YWHAD | |
Cytomap | UCSC genome browser: 8q23.1 | |
Genomic location | chr8 :101930803-101962799 | |
Type of gene | protein-coding | |
RefGenes | NM_001135699.1, NM_001135700.1,NM_001135701.1,NM_001135702.1,NM_003406.3, NM_145690.2, | |
Ensembl id | ENSG00000164924 | |
Description | 14-3-3 delta14-3-3 protein zeta/delta14-3-3 protein/cytosolic phospholipase A214-3-3 zetaepididymis luminal protein 4epididymis secretory protein Li 3phospholipase A2protein kinase C inhibitor protein 1protein kinase C inhibitor protein-1tyrosine | |
Modification date | 20141222 | |
dbXrefs | MIM : 601288 | |
HGNC : HGNC | ||
Ensembl : ENSG00000164924 | ||
HPRD : 03183 | ||
Vega : OTTHUMG00000134291 | ||
Protein | UniProt: P63104 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_YWHAZ | |
BioGPS: 7534 | ||
Gene Expression Atlas: ENSG00000164924 | ||
The Human Protein Atlas: ENSG00000164924 | ||
Pathway | NCI Pathway Interaction Database: YWHAZ | |
KEGG: YWHAZ | ||
REACTOME: YWHAZ | ||
ConsensusPathDB | ||
Pathway Commons: YWHAZ | ||
Metabolism | MetaCyc: YWHAZ | |
HUMANCyc: YWHAZ | ||
Regulation | Ensembl's Regulation: ENSG00000164924 | |
miRBase: chr8 :101,930,803-101,962,799 | ||
TargetScan: NM_001135699 | ||
cisRED: ENSG00000164924 | ||
Context | iHOP: YWHAZ | |
cancer metabolism search in PubMed: YWHAZ | ||
UCL Cancer Institute: YWHAZ | ||
Assigned class in ccmGDB | B - This gene belongs to cancer gene. |
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Phenotypic Information for YWHAZ(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: YWHAZ |
Familial Cancer Database: YWHAZ |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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REACTOME_METABOLISM_OF_MRNA REACTOME_METABOLISM_OF_RNA |
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OMIM | 601288; gene. 601288; gene. |
Orphanet | |
Disease | KEGG Disease: YWHAZ |
MedGen: YWHAZ (Human Medical Genetics with Condition) | |
ClinVar: YWHAZ | |
Phenotype | MGI: YWHAZ (International Mouse Phenotyping Consortium) |
PhenomicDB: YWHAZ |
Mutations for YWHAZ |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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- Statistics for Tissue and Mutation type | Top |
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- For Inter-chromosomal Variations |
There's no inter-chromosomal structural variation. |
- For Intra-chromosomal Variations |
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'. |
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Sample | Symbol_a | Chr_a | Start_a | End_a | Symbol_b | Chr_b | Start_b | End_b |
ovary | YWHAZ | chr8 | 101936730 | 101936930 | chr8 | 101757242 | 101757442 | |
ovary | YWHAZ | chr8 | 101951124 | 101951144 | YWHAZ | chr8 | 101951174 | 101951194 |
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract) |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows YWHAZ related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
AA307240 | SRCAP | 9 | 116 | 16 | 30748537 | 30748642 | YWHAZ | 109 | 415 | 8 | 101960844 | 101964177 | |
BG284443 | YWHAZ | 1 | 337 | 8 | 101936487 | 101960996 | NDUFB9 | 330 | 501 | 8 | 125562047 | 125562218 | |
DB135580 | YWHAZ | 1 | 121 | 8 | 101965496 | 101965616 | AZIN1 | 119 | 549 | 8 | 103851958 | 103870380 | |
BF754131 | YWHAZ | 21 | 74 | 8 | 101947415 | 101947468 | ACTL6A | 72 | 334 | 3 | 179304363 | 179305922 | |
BG985122 | YWHAZ | 22 | 137 | 8 | 101943586 | 101943701 | CAMTA2 | 129 | 242 | 17 | 4875587 | 4875700 | |
AI761355 | YWHAZ | 1 | 190 | 8 | 101951468 | 101951657 | ABCC3 | 188 | 273 | 17 | 48721338 | 48721423 | |
BF910449 | YWHAZ | 3 | 205 | 8 | 101942751 | 101942953 | YWHAZ | 203 | 413 | 8 | 101942158 | 101942368 | |
BF329619 | KIF7 | 19 | 281 | 15 | 90175272 | 90175540 | YWHAZ | 277 | 350 | 8 | 101935311 | 101935384 | |
AW860114 | YWHAZ | 7 | 250 | 8 | 101961160 | 101961402 | DYRK1A | 247 | 309 | 21 | 38741268 | 38741331 |
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Mutation type/ Tissue ID | brca | cns | cerv | endome | haematopo | kidn | Lintest | liver | lung | ns | ovary | pancre | prost | skin | stoma | thyro | urina | |||
Total # sample | 1 |   | 1 | 1 |   |   |   |   | 1 |   | 2 |   |   |   |   |   |   | |||
GAIN (# sample) | 1 |   | 1 | 1 |   |   |   |   | 1 |   | 2 |   |   |   |   |   |   | |||
LOSS (# sample) |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract) |
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Stat. for Non-Synonymous SNVs (# total SNVs=17) | (# total SNVs=9) |
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(# total SNVs=0) | (# total SNVs=2) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr8:101960848-101960848 | p.L90L | 2 |
chr8:101960863-101960863 | p.K85N | 2 |
chr8:101932928-101932929 | p.E244fs*>3 | 2 |
chr8:101960878-101960878 | p.R80R | 2 |
chr8:101932962-101932962 | p.Q233E | 1 |
chr8:101937250-101937250 | p.F104L | 1 |
chr8:101960887-101960887 | p.Q77H | 1 |
chr8:101932970-101932970 | p.S230L | 1 |
chr8:101960825-101960825 | p.L98P | 1 |
chr8:101960935-101960935 | p.V61V | 1 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 1 | 1 |   | 2 |   |   | 2 |   |   |   |   | 1 |   |   |   |   |   | 3 |   | 1 |
# mutation | 1 | 1 |   | 2 |   |   | 2 |   |   |   |   | 1 |   |   |   |   |   | 3 |   | 1 |
nonsynonymous SNV | 1 | 1 |   | 1 |   |   | 2 |   |   |   |   |   |   |   |   |   |   | 2 |   | 1 |
synonymous SNV |   |   |   | 1 |   |   |   |   |   |   |   | 1 |   |   |   |   |   | 1 |   |   |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr8:101936216 | p.S230L,YWHAZ | 1 |
chr8:101936232 | p.L220V,YWHAZ | 1 |
chr8:101936241 | p.I217T,YWHAZ | 1 |
chr8:101937190 | p.T215T,YWHAZ | 1 |
chr8:101937250 | p.S210L,YWHAZ | 1 |
chr8:101960911 | p.S207I,YWHAZ | 1 |
chr8:101961019 | p.D124E,YWHAZ | 1 |
chr8:101932959 | p.F104L,YWHAZ | 1 |
chr8:101961020 | p.T69T,YWHAZ | 1 |
chr8:101932970 | p.G33G,YWHAZ | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for YWHAZ |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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ANKRD46,ATP6V1C1,AZIN1,DCAF13,DERL1,EBAG9,ESRP1, INTS8,MTDH,MTERF3,NUDCD1,OTUD6B,POLR2K,PTDSS1, RAD21,RAD54B,SLC25A32,STK3,EMC2,YWHAZ,ZNF706 | CALM2,CHMP2B,DYNLT3,FAM49B,GOLT1B,BBIP1,NDFIP1, PLEKHA3,POLR2K,LRR1,RAB28,RAP1B,RNF139,SLC25A32, STK3,TCEA1,TRAM1,VPS26A,YPEL5,YWHAZ,ZNF706 |
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ATP6V1C1,AZIN1,CHRAC1,CPNE3,DCAF13,DERL1,EBAG9, ENY2,RMDN1,FAM91A1,NUDCD1,POLR2K,RAB2A,RAD21, RNF139,SLC25A32,TCEB1,EMC2,UBE2V2,YWHAZ,ZNF706 | AAGAB,ATG4A,C12orf49,CAP1,CHMP2B,MICU2,GMFB, HDAC1,NIPA2,PEX13,PPP6C,RAB11A,RALA,SLC25A24, STX19,TMEM167A,TPMT,UBE2K,VPS26A,YWHAB,YWHAZ |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for YWHAZ |
There's no related Drug. |
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Cross referenced IDs for YWHAZ |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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