Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

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	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for MOGS

Basic gene info.	Gene symbol	MOGS
	Gene name	mannosyl-oligosaccharide glucosidase
	Synonyms	CDG2B\|CWH41\|DER7\|GCS1
	Cytomap	UCSC genome browser: 2p13.1
	Genomic location	chr2 :74688183-74692537
	Type of gene	protein-coding
	RefGenes	NM_001146158.1, NM_006302.2,
	Ensembl id	ENSG00000115275
	Description	glucosidase Iprocessing A-glucosidase I
	Modification date	20141219
dbXrefs	MIM : 601336
	HGNC : HGNC
	Ensembl : ENSG00000115275
	HPRD : 03214
	Vega : OTTHUMG00000152886
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_MOGS
	BioGPS: 7841
	Gene Expression Atlas: ENSG00000115275
	The Human Protein Atlas: ENSG00000115275
Pathway	NCI Pathway Interaction Database: MOGS
	KEGG: MOGS
	REACTOME: MOGS
	ConsensusPathDB
	Pathway Commons: MOGS
Metabolism	MetaCyc: MOGS
	HUMANCyc: MOGS
Regulation	Ensembl's Regulation: ENSG00000115275
	miRBase: chr2 :74,688,183-74,692,537
	TargetScan: NM_001146158
	cisRED: ENSG00000115275
Context	iHOP: MOGS
	cancer metabolism search in PubMed: MOGS
	UCL Cancer Institute: MOGS
Assigned class in ccmGDB	C

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Phenotypic Information for MOGS(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: MOGS
	Familial Cancer Database: MOGS

* This gene is included in those cancer gene databases.

						.
Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in	Therapeutic Vulnerabilities in Cancer¹

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
REACTOME_METABOLISM_OF_PROTEINS

Others
OMIM
Orphanet
Disease	KEGG Disease: MOGS
	MedGen: MOGS (Human Medical Genetics with Condition)
	ClinVar: MOGS
Phenotype	MGI: MOGS (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: MOGS

Mutations for MOGS

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

There's no structural variation information in COSMIC data for this gene.

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows MOGS related fusion information.

ID	Head Gene						Tail Gene
Accession	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a
BG979303	MOGS	10	112	2	74689490	74689596	MOGS	112	245	2	74688425	74688558
BF899407	MOGS	1	210	2	74688491	74689159	HBB	208	505	11	5246906	5248183
BF899427	MOGS	7	210	2	74688491	74688694	HBB	208	508	11	5246903	5248183
BF803127	MOGS	15	135	2	74689405	74689528	MALAT1	128	433	11	65271740	65272046
DA571383	INO80B	1	203	2	74686976	74687172	MOGS	191	718	2	74691438	74691965

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

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Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

There's no copy number variation information in COSMIC data for this gene.

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SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=3

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Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=50)	Stat. for Synonymous SNVs (# total SNVs=9)

Stat. for Deletions (# total SNVs=1)	Stat. for Insertions (# total SNVs=1)

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Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr2:74688908-74688908	p.Q670E	3
chr2:74691708-74691708	p.A165D	2
chr2:74688678-74688678	p.D746D	2
chr2:74689312-74689312	p.R535Q	2
chr2:74690475-74690475	p.F206F	2
chr2:74689078-74689078	p.R613Q	2
chr2:74690323-74690323	p.Y257C	2
chr2:74689928-74689928	p.I330V	1
chr2:74692262-74692262	p.R38L	1
chr2:74688844-74688844	p.Y691S	1

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SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample	5	2	1	11			5					7	3		1		3	12		9
# mutation	5	2	1	11			5					7	4		1		3	14		9
nonsynonymous SNV	4	2	1	8			5					5	3				1	10		6
synonymous SNV	1			3								2	1		1		2	4		3

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chr2:74688908	p.P128L,MOGS	2
chr2:74691819	p.G299S,MOGS	2
chr2:74689172	p.Q670E,MOGS	2
chr2:74690021	p.L582L,MOGS	2
chr2:74690042	p.L573P,MOGS	1
chr2:74688900	p.N346S,MOGS	1
chr2:74689328	p.Q179P,MOGS	1
chr2:74691753	p.R720R,MOGS	1
chr2:74689839	p.R565Q,MOGS	1
chr2:74688678	p.F334S,MOGS	1

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for MOGS in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for MOGS

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

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CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

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Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


ATAD3A,B4GALT2,PRADC1,CTU2,DAZAP1,ECE2,FAM58A, GTF2H4,HTRA2,LEMD2,MOGS,MUTYH,PCGF1,PLOD3, PREB,PRKCSH,RTKN,SMYD5,TMUB1,WDR46,YIPF2	ANAPC2,ARFGAP1,C19orf25,CC2D1A,CNOT3,CXXC1,EHMT2, GAK,GGA1,HMG20B,MAN1B1,MOGS,NDOR1,PPOX, RABEP2,RHOT2,SLC12A9,SPPL2B,TARBP2,TRIM11,TRIM28

AHSA2,ANKS3,ATG4B,CEP131,C2orf68,RABL6,CAPN10, CDK10,E4F1,EIF2B4,ING5,KANSL3,MOGS,RECQL5, SMPD4,SNAPC4,SNRNP70,STK25,SUPT7L,TMCO6,ZNF142	ABCF3,ADRBK1,AP1G2,ARHGEF10L,ATP13A1,ATP6AP1,GPR56, GTF3C2,HDAC6,IGSF8,KIAA1804,LPAR5,MEN1,MOGS, POLG,RFX1,SEMA4G,SH3RF2,SYK,TYK2,ZBED4

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

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Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for MOGS

There's no related Drug.

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Cross referenced IDs for MOGS

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information