Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for MBOAT7
Basic gene info.Gene symbolMBOAT7
Gene namemembrane bound O-acyltransferase domain containing 7
SynonymsBB1|LENG4|LPIAT|LRC4|MBOA7|OACT7|hMBOA-7
CytomapUCSC genome browser: 19q13.4
Genomic locationchr19 :54677105-54693733
Type of geneprotein-coding
RefGenesNM_001146056.2,
NM_001146082.2,NM_001146083.2,NM_024298.4,
Ensembl idENSG00000261917
Description1-acylglycerophosphatidylinositol O-acyltransferaseLPLAT 7bladder and breast carcinoma-overexpressed gene 1 proteinh-mboa-7leukocyte receptor cluster (LRC) member 4lyso-PI acyltransferaselysophosphatidylinositol acyltransferaselysophospholipid acyl
Modification date20141211
dbXrefs MIM : 606048
HGNC : HGNC
Ensembl : ENSG00000125505
HPRD : 06925
Vega : OTTHUMG00000066516
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MBOAT7
BioGPS: 79143
Gene Expression Atlas: ENSG00000261917
The Human Protein Atlas: ENSG00000261917
PathwayNCI Pathway Interaction Database: MBOAT7
KEGG: MBOAT7
REACTOME: MBOAT7
ConsensusPathDB
Pathway Commons: MBOAT7
MetabolismMetaCyc: MBOAT7
HUMANCyc: MBOAT7
RegulationEnsembl's Regulation: ENSG00000261917
miRBase: chr19 :54,677,105-54,693,733
TargetScan: NM_001146056
cisRED: ENSG00000261917
ContextiHOP: MBOAT7
cancer metabolism search in PubMed: MBOAT7
UCL Cancer Institute: MBOAT7
Assigned class in ccmGDBC

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Phenotypic Information for MBOAT7(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: MBOAT7
Familial Cancer Database: MBOAT7
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_GLYCEROPHOSPHOLIPID_METABOLISM
REACTOME_PHOSPHOLIPID_METABOLISM
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: MBOAT7
MedGen: MBOAT7 (Human Medical Genetics with Condition)
ClinVar: MBOAT7
PhenotypeMGI: MBOAT7 (International Mouse Phenotyping Consortium)
PhenomicDB: MBOAT7

Mutations for MBOAT7
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram

- Statistics for Tissue and Mutation typeTop
- For Inter-chromosomal Variations
There's no inter-chromosomal structural variation.
- For Intra-chromosomal Variations
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'.
SampleSymbol_aChr_aStart_aEnd_aSymbol_bChr_bStart_bEnd_b
ovaryMBOAT7chr195468299654683016MBOAT7chr195468642454686444
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract)

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows MBOAT7 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
BF877350C19orf6153421910115891012159MBOAT7329505195467782654678003
AV726722SDSL1233712113872004113874629MBOAT7332555195467711254677335
AV727483SDSL132612113872004113874629MBOAT7321499195467715754677335
BF919648MBOAT72238195468826954688505MBOAT7235393195469091154691069

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=3

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=29)
Stat. for Synonymous SNVs
(# total SNVs=12)
Stat. for Deletions
(# total SNVs=2)
Stat. for Insertions
(# total SNVs=0)
There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr19:54677813-54677813p.G448G3
chr19:54678121-54678121p.A346T2
chr19:54684811-54684811p.E178G2
chr19:54684658-54684658p.A229G2
chr19:54692145-54692145p.F44L2
chr19:54677759-54677759p.P466P1
chr19:54684685-54684685p.D220G1
chr19:54677935-54677935p.D408H1
chr19:54687484-54687484p.P138L1
chr19:54692331-54692331p.V11A1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample52 21 8     2 1125 11
# mutation52 21 7     2 1125 14
nonsynonymous SNV4  21 5     1  122 9
synonymous SNV12    2     1 1  3 5
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr19:54677813p.G375G,MBOAT72
chr19:54677887p.R351W,MBOAT72
chr19:54677780p.S386S,MBOAT71
chr19:54691160p.Y290C,MBOAT71
chr19:54677942p.H72H,MBOAT71
chr19:54682578p.A385S,MBOAT71
chr19:54677785p.G284S,MBOAT71
chr19:54692078p.P36Q,MBOAT71
chr19:54677944p.T275T,MBOAT71
chr19:54684691p.S34A,MBOAT71

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for MBOAT7 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for MBOAT7

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

AKT1S1,AP2A1,CCDC106,CNOT3,EPN1,FIZ1,ISOC2,
LENG1,MBOAT7,MED25,NAT14,PPP2R1A,PRPF31,PTOV1,
PPP6R1,TFPT,TMC4,TSEN34,ZNF444,ZNF579,ZNF581
AP1M2,AP1S1,ARRDC1,EMC10,CACFD1,CHPF,DAK,
LMAN2,LPAR2,LSR,MBOAT7,MTFP1,PAFAH1B3,PAK4,
PRPF19,PVRL2,SCAMP4,SLC35A2,SPINT2,TMED3,TMEM102

ALDH16A1,CALM3,CBLC,CLPTM1,DEDD2,GRIN2D,KDELR1,
LPAR5,LSR,MBOAT7,MICALL2,PAK4,PLCB3,PLLP,
PRKD2,PVRL2,PXN,SIRT7,SPINT2,UBE2M,UNC93B1
KIAA1211L,CTDP1,CTSD,DENND1C,DKFZp761E198,EPN1,IL17RE,
INF2,KIAA1522,CAMSAP3,MAP3K11,MBOAT7,MPND,NR2F6,
PRKCZ,SIPA1L3,SPINT1,TMC4,TMEM102,VILL,VIPR1
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for MBOAT7


There's no related Drug.
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Cross referenced IDs for MBOAT7
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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