Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

Home

Search

Download

 Statistics

Help

About Us
Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for GALNT14
Basic gene info.Gene symbolGALNT14
Gene namepolypeptide N-acetylgalactosaminyltransferase 14
SynonymsGALNT15|GalNac-T10|GalNac-T14
CytomapUCSC genome browser: 2p23.1
Genomic locationchr2 :31133330-31361592
Type of geneprotein-coding
RefGenesNM_001253826.1,
NM_001253827.1,NM_024572.3,NR_045602.1,
Ensembl idENSG00000158089
DescriptionUDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 14UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase T10UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase T14UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltran
Modification date20141207
dbXrefs MIM : 608225
HGNC : HGNC
Ensembl : ENSG00000158089
HPRD : 12194
Vega : OTTHUMG00000074077
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_GALNT14
BioGPS: 79623
Gene Expression Atlas: ENSG00000158089
The Human Protein Atlas: ENSG00000158089
PathwayNCI Pathway Interaction Database: GALNT14
KEGG: GALNT14
REACTOME: GALNT14
ConsensusPathDB
Pathway Commons: GALNT14
MetabolismMetaCyc: GALNT14
HUMANCyc: GALNT14
RegulationEnsembl's Regulation: ENSG00000158089
miRBase: chr2 :31,133,330-31,361,592
TargetScan: NM_001253826
cisRED: ENSG00000158089
ContextiHOP: GALNT14
cancer metabolism search in PubMed: GALNT14
UCL Cancer Institute: GALNT14
Assigned class in ccmGDBC

Top
Phenotypic Information for GALNT14(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: GALNT14
Familial Cancer Database: GALNT14
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
REACTOME_METABOLISM_OF_PROTEINS

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: GALNT14
MedGen: GALNT14 (Human Medical Genetics with Condition)
ClinVar: GALNT14
PhenotypeMGI: GALNT14 (International Mouse Phenotyping Consortium)
PhenomicDB: GALNT14

Mutations for GALNT14
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram

- Statistics for Tissue and Mutation typeTop
- For Inter-chromosomal Variations
There's no inter-chromosomal structural variation.
- For Intra-chromosomal Variations
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'.
SampleSymbol_aChr_aStart_aEnd_aSymbol_bChr_bStart_bEnd_b
breastGALNT14chr23120785331207853SPATS2Lchr2201339517201339517
ovaryGALNT14chr23119066331190683ITGB6chr2161042792161042812
ovaryGALNT14chr23124994831249968GALNT14chr23125011331250133
pancreasGALNT14chr23127942131279441chr21199105611991076
pancreasGALNT14chr23128140231281422NRXN1chr25035016250350182
pancreasGALNT14chr23129160831291628chr21042429610424316
pancreasGALNT14chr23132548931325509chr23257693332576953
pancreasGALNT14chr23132986831329888chr21367857113678591
pancreasGALNT14chr23133241931332439NRXN1chr25057082650570846
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract)

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows GALNT14 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
BU676719GALNT141821423113333331133529GALNT1420941723113350231133710
CV383660KIAA12172287102479940224799687GALNT1428134823137600331376070
BU679527GALNT141821323113333331133529GALNT1420841623113350231133710
BU685357GALNT141821423113333331133529GALNT1420941723113350231133710
CF143349GALNT14714723127790731278047GALNT1414148723128258031282926
AK024039GALNT142162023114706431361369LAMTOR2161922241156024587156028296
BQ358366KIAA12171315102479937024799687GALNT1430937623137600331376070

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

Top
check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
 
Mutation type/ Tissue IDbrcacnscervendomehaematopokidnLintestliverlungnsovarypancreprostskinstomathyrourina
Total # sample      1   1  11  
GAIN (# sample)          1  11  
LOSS (# sample)      1          
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

Top
check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=4

Top
check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=66)		Stat. for Synonymous SNVs
(# total SNVs=37)
Stat. for Deletions
(# total SNVs=0)		Stat. for Insertions
(# total SNVs=0)
There's no deleted snv.There's no inserted snv.

Top
check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr2:31178570-31178570p.A190T4
chr2:31165143-31165143p.F285F4
chr2:31133827-31133827p.I533I4
chr2:31178795-31178795p.R172H3
chr2:31167740-31167740p.P271S3
chr2:31165103-31165103p.D299N2
chr2:31215847-31215847p.L52L2
chr2:31165110-31165110p.G296G2
chr2:31155016-31155016p.V326I2
chr2:31133839-31133839p.N529N2

Top
check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=3

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample 11163 5    17551 28919
# mutation 11163 5    18541 3510111
nonsynonymous SNV  1133 5    9421 21716
synonymous SNV 1 3       912  143 5
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

Top
check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr2:31133827p.F285L,GALNT143
chr2:31165143p.I533I,GALNT143
chr2:31154991p.V334G,GALNT143
chr2:31133788p.H546H,GALNT142
chr2:31215756p.A486T,GALNT142
chr2:31147092p.G296G,GALNT142
chr2:31168704p.P484S,GALNT142
chr2:31147108p.R268C,GALNT142
chr2:31168707p.E83K,GALNT142
chr2:31135133p.R172H,GALNT142

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for GALNT14 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

Top
Gene Expression for GALNT14

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
Top
check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


Top
Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

LINC00488,CDC25A,CENPA,CHEK2,DGKG,EPCAM,FAM136A,
FAM64A,FOXM1,GALNT14,GAPDH,GPRIN1,IL13RA2,LRP8,
NCAPD2,PSAT1,RANBP1,TRIM51,TEAD4,TPI1,YARS		CADM4,COL8A2,D4S234E,DLK2,FJX1,GALNT14,IL34,
IL4R,ITGB4,JAG2,KRT14,KRT5,LAMC2,PDLIM4,
PLD4,PPP1R13L,RIPK4,SFN,TACSTD2,TRIM29,WNT10A

BDNF,ANKUB1,DPY19L2P4,GALNT14,GRM5,GUCA1C,IL1RL1,
KHDC1L,KRT1,MBL1P,NRK,NTF4,OR10H4,PCDH9,
PLGLA,SACS,SLC35F3,SPANXA2,SPANXB2,SYT16,UTS2B		AADAC,ABCC2,CCL25,CPO,CRISP1,FAM99A,FAM99B,
FMO1,GALNT14,GRAMD1B,GSTA5,LCE3E,LOC388428,MME,
MOS,ONECUT3,OR10H1,OR10H5,OR4N5,PWAR4___F2RL3___PAWR,SHBG,
SLC28A1,SLC2A2,SOAT2,SPA
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

Top
check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

Top
Pharmacological Information for GALNT14


There's no related Drug.
Top
Cross referenced IDs for GALNT14
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



Copyright © 2016-Present - The Univsersity of Texas Health Science Center at Houston @
Site Policies | State of Texas