Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for GEMIN7
Basic gene info.Gene symbolGEMIN7
Gene namegem (nuclear organelle) associated protein 7
SynonymsSIP3
CytomapUCSC genome browser: 19q13.32
Genomic locationchr19 :45582529-45594782
Type of geneprotein-coding
RefGenesNM_001007269.1,
NM_001007270.1,NM_024707.2,
Ensembl idENSG00000142252
Descriptiongem-associated protein 7gemin 7gemin-7
Modification date20141207
dbXrefs MIM : 607419
HGNC : HGNC
Ensembl : ENSG00000142252
HPRD : 07600
Vega : OTTHUMG00000181768
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_GEMIN7
BioGPS: 79760
Gene Expression Atlas: ENSG00000142252
The Human Protein Atlas: ENSG00000142252
PathwayNCI Pathway Interaction Database: GEMIN7
KEGG: GEMIN7
REACTOME: GEMIN7
ConsensusPathDB
Pathway Commons: GEMIN7
MetabolismMetaCyc: GEMIN7
HUMANCyc: GEMIN7
RegulationEnsembl's Regulation: ENSG00000142252
miRBase: chr19 :45,582,529-45,594,782
TargetScan: NM_001007269
cisRED: ENSG00000142252
ContextiHOP: GEMIN7
cancer metabolism search in PubMed: GEMIN7
UCL Cancer Institute: GEMIN7
Assigned class in ccmGDBC

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Phenotypic Information for GEMIN7(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: GEMIN7
Familial Cancer Database: GEMIN7
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
REACTOME_METABOLISM_OF_NON_CODING_RNA
REACTOME_METABOLISM_OF_RNA

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: GEMIN7
MedGen: GEMIN7 (Human Medical Genetics with Condition)
ClinVar: GEMIN7
PhenotypeMGI: GEMIN7 (International Mouse Phenotyping Consortium)
PhenomicDB: GEMIN7

Mutations for GEMIN7
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram

- Statistics for Tissue and Mutation typeTop
- For Inter-chromosomal Variations
There's no inter-chromosomal structural variation.
- For Intra-chromosomal Variations
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'.
SampleSymbol_aChr_aStart_aEnd_aSymbol_bChr_bStart_bEnd_b
ovaryGEMIN7chr194559298845593008CLASRPchr194556913945569159
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract)

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows GEMIN7 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
 
Mutation type/ Tissue IDbrcacnscervendomehaematopokidnLintestliverlungnsovarypancreprostskinstomathyrourina
Total # sample        1        
GAIN (# sample)        1        
LOSS (# sample)                 
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=3

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=14)
Stat. for Synonymous SNVs
(# total SNVs=4)
Stat. for Deletions
(# total SNVs=0)
Stat. for Insertions
(# total SNVs=0)
There's no deleted snv.There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr19:45593382-45593382p.P4T1
chr19:45593553-45593553p.A61T1
chr19:45593700-45593700p.P110S1
chr19:45593386-45593386p.V5A1
chr19:45593555-45593555p.A61A1
chr19:45593723-45593723p.A117A1
chr19:45593388-45593388p.N6D1
chr19:45593559-45593559p.R63W1
chr19:45593739-45593739p.D123N1
chr19:45593461-45593461p.R30L1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample1  3  1 1  422 122 3
# mutation1  3  1 1  522 122 3
nonsynonymous SNV1  2  1 1  4 2 112 2
synonymous SNV   1       12   1  1
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr19:45593559p.R63W,GEMIN72
chr19:45593386p.G85G,GEMIN71
chr19:45593756p.R87H,GEMIN71
chr19:45593388p.V5A,GEMIN71
chr19:45593579p.G93A,GEMIN71
chr19:45593435p.N6D,GEMIN71
chr19:45593596p.D96N,GEMIN71
chr19:45593461p.F21F,GEMIN71
chr19:45593627p.P110S,GEMIN71
chr19:45593483p.R30L,GEMIN71

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for GEMIN7 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for GEMIN7

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

AP2S1,UQCC3,ERCC1,EXOSC5,GEMIN7,IRF2BP1,IRF3,
MYPOP,POLR2I,QPCTL,RBM42,RPS19,SDHAF1,SNRPD2,
TOMM40,TRAPPC6A,UBE2M,ZNF428,ZNF524,ZNF576,ZNHIT1
ARF5,C16orf91,COA4,CUTA,DNAJC4,ETHE1,GEMIN7,
HSD11B1L,LAGE3,LCMT1,NHP2L1,OTUB1,POLR2H,PRCC,
PTOV1,TARBP2,TMEM134,TMEM141,TSEN34,VPS25,WRAP53

C19orf53,ECE2,GADD45GIP1,GEMIN7,MRPL11,MRPL54,MRPS12,
MYEOV2,NDUFA11,NDUFA13,NDUFB7,NME1,PRMT1,RPS16,
RPS5,RUVBL2,SNRPD2,TIMM50,TIMM8B,UQCR11,ZNF576
ABT1,ANAPC5,ARV1,ATP6V0B,CYC1,DCTPP1,DPM3,
FLAD1,GEMIN7,INTS10,MED11,MRPL54,MRPS12,NPRL2,
STK16,STOML2,TARBP2,TMEM183A,TMEM223,TRUB2,ZNHIT1
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for GEMIN7


There's no related Drug.
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Cross referenced IDs for GEMIN7
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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