Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

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	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for TUSC3

Basic gene info.	Gene symbol	TUSC3
	Gene name	tumor suppressor candidate 3
	Synonyms	D8S1992\|M33\|MRT22\|MRT7\|N33\|OST3A
	Cytomap	UCSC genome browser: 8p22
	Genomic location	chr8 :15397595-15624158
	Type of gene	protein-coding
	RefGenes	NM_006765.3, NM_178234.2,
	Ensembl id	ENSG00000104723
	Description	Putative prostate cancer tumor suppressormagnesium uptake/transporter TUSC3oligosaccharyltransferase 3 homolog A
	Modification date	20141219
dbXrefs	MIM : 601385
	HGNC : HGNC
	Ensembl : ENSG00000104723
	HPRD : 03228
	Vega : OTTHUMG00000094803
Protein	UniProt: Q13454 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_TUSC3
	BioGPS: 7991
	Gene Expression Atlas: ENSG00000104723
	The Human Protein Atlas: ENSG00000104723
Pathway	NCI Pathway Interaction Database: TUSC3
	KEGG: TUSC3
	REACTOME: TUSC3
	ConsensusPathDB
	Pathway Commons: TUSC3
Metabolism	MetaCyc: TUSC3
	HUMANCyc: TUSC3
Regulation	Ensembl's Regulation: ENSG00000104723
	miRBase: chr8 :15,397,595-15,624,158
	TargetScan: NM_006765
	cisRED: ENSG00000104723
Context	iHOP: TUSC3
	cancer metabolism search in PubMed: TUSC3
	UCL Cancer Institute: TUSC3
Assigned class in ccmGDB	B - This gene belongs to cancer gene.

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Phenotypic Information for TUSC3(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: TUSC3
	Familial Cancer Database: TUSC3

* This gene is included in those cancer gene databases.

						.
Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in	Therapeutic Vulnerabilities in Cancer¹

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
REACTOME_METABOLISM_OF_PROTEINS

Others
OMIM	601385; gene. 611093; phenotype.
Orphanet	88616; Autosomal recessive non-syndromic intellectual disability.
Disease	KEGG Disease: TUSC3
	MedGen: TUSC3 (Human Medical Genetics with Condition)
	ClinVar: TUSC3
Phenotype	MGI: TUSC3 (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: TUSC3

Mutations for TUSC3

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

- Statistics for Tissue and Mutation type

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- For Inter-chromosomal Variations

There's no inter-chromosomal structural variation.

- For Intra-chromosomal Variations

* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'.

Sample	Symbol_a	Chr_a	Start_a	End_a	Symbol_b	Chr_b	Start_b	End_b
ovary	TUSC3	chr8	15441626	15441646	TUSC3	chr8	15441800	15441820

cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract)

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows TUSC3 related fusion information.

Head Gene

Tail Gene

Accession

Gene_a

qStart_a

qEnd_a

Chromosome_a

tStart_a

tEnd_a

Gene_a

qStart_a

qEnd_a

Chromosome_a

tStart_a

tEnd_a

BF990912

ARHGEF7

371

111955946

111956281

TUSC3

365

622

15397987

15480755

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

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Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

Mutation type/ Tissue ID

brca

cns

cerv

endome

haematopo

kidn

Lintest

liver

lung

ovary

pancre

prost

skin

stoma

thyro

urina

Total # sample

GAIN (# sample)

LOSS (# sample)

cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=7

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Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=59)	Stat. for Synonymous SNVs (# total SNVs=14)

Stat. for Deletions (# total SNVs=0)	Stat. for Insertions (# total SNVs=0)
There's no deleted snv.	There's no inserted snv.

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Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr8:15605946-15605946	p.R334C	6
chr8:15480695-15480695	p.R82L	4
chr8:15480646-15480646	p.F66I	3
chr8:15508247-15508247	p.R117H	2
chr8:15605922-15605922	p.F326L	2
chr8:15480717-15480717	p.M89I	2
chr8:15397952-15397952	p.G5S	2
chr8:15517163-15517163	p.?	2
chr8:15480637-15480637	p.R63C	2
chr8:15519674-15519674	p.F193L	2

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SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=4

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample				14	4		3		2	1	1	9	3	1	1		10	15		6
# mutation				15	4		3		2	1	1	8	3	1	1		9	14		6
nonsynonymous SNV				9	3		3		1	1	1	6	2	1	1		6	13		6
synonymous SNV				6	1				1			2	1				3	1

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chr8:15605946	p.R334C,TUSC3	4
chr8:15480646	p.F66V,TUSC3	4
chr8:15480695	p.R74L,TUSC3	3
chr8:15480671	p.R82Q,TUSC3	3
chr8:15517134	p.A290T,TUSC3	2
chr8:15605922	p.A113A,TUSC3	2
chr8:15508236	p.I182T,TUSC3	2
chr8:15601052	p.R117C,TUSC3	2
chr8:15508246	p.R117H,TUSC3	2
chr8:15508247	p.F326V,TUSC3	2

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for TUSC3 in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for TUSC3

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

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CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

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Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


AGPAT5,C8orf48,C9orf72,CNOT7,EXTL3,INTS10,KCTD9, LONRF1,PBK,PLAA,POLR3D,RAVER2,RRAGA,SCGB1D4, SRSF12,SLC39A14,TUSC3,UGT2A1,VPS37A,XPO7,ZDHHC2	ATL1,B3GALNT1,RHNO1,VWA9,FAXC,CD24,CDS1, CTBP2,DYX1C1,E2F5,ESRP1,KCTD1,LRRC8D,MARVELD2, OAT,PAICS,PRMT6,SPATS2,SSX2IP,TUSC3,YTHDF2

BCL6B,CLEC1A,CNRIP1,DSEL,DZIP1,ECSCR,EFS, ELOVL4,FAM101B,FAM110B,FBXL7,FSTL1,GUCY1B3,KIAA1462, LAMA4,LDB2,LPHN2,THBD,THY1,TRPV2,TUSC3	AVPR1B,CCDC85A,CFC1B,CPB1,CRH,CYP2W1,FMOD, GABRA6,GPR12,HOXD12,INSL5,KCNK15,LOC440925,PCSK1, RIMS4,SCG5,SLC26A4,TBX4,TNNC1,TPH1,TUSC3

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

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Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for TUSC3

There's no related Drug.

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Cross referenced IDs for TUSC3

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information