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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for ELOVL7 |
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Phenotypic Information for ELOVL7(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: ELOVL7 |
Familial Cancer Database: ELOVL7 |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS |
Others | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: ELOVL7 |
MedGen: ELOVL7 (Human Medical Genetics with Condition) | |
ClinVar: ELOVL7 | |
Phenotype | MGI: ELOVL7 (International Mouse Phenotyping Consortium) |
PhenomicDB: ELOVL7 |
Mutations for ELOVL7 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
- Statistics for Tissue and Mutation type | Top |
- For Inter-chromosomal Variations |
There's no inter-chromosomal structural variation. |
- For Intra-chromosomal Variations |
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'. |
Sample | Symbol_a | Chr_a | Start_a | End_a | Symbol_b | Chr_b | Start_b | End_b |
ovary | ELOVL7 | chr5 | 60077078 | 60077098 | NDUFAF2 | chr5 | 60242168 | 60242188 |
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract) |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ELOVL7 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
AI934581 | PAFAH1B1 | 14 | 130 | 17 | 2497210 | 2541418 | ELOVL7 | 130 | 550 | 5 | 60047749 | 60048169 | |
AA506314 | ELOVL7 | 4 | 83 | 5 | 60048105 | 60048184 | ELOVL7 | 79 | 256 | 5 | 60047982 | 60048159 | |
BQ340167 | ELOVL7 | 10 | 113 | 5 | 60128753 | 60128856 | DSE | 109 | 191 | 6 | 116599271 | 116599354 |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
Mutation type/ Tissue ID | brca | cns | cerv | endome | haematopo | kidn | Lintest | liver | lung | ns | ovary | pancre | prost | skin | stoma | thyro | urina | |||
Total # sample | 1 |   | 1 |   |   |   |   |   | 1 |   | 1 |   | 1 |   |   |   |   | |||
GAIN (# sample) |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   | |||
LOSS (# sample) | 1 |   | 1 |   |   |   |   |   | 1 |   | 1 |   | 1 |   |   |   |   |
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract) |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=19) | (# total SNVs=5) |
(# total SNVs=1) | (# total SNVs=1) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr5:60053463-60053463 | p.G170E | 2 |
chr5:60067911-60067911 | p.V25D | 2 |
chr5:60067809-60067809 | p.R59H | 2 |
chr5:60060157-60060157 | p.I132I | 1 |
chr5:60067810-60067810 | p.R59C | 1 |
chr5:60053392-60053392 | p.G194W | 1 |
chr5:60062459-60062459 | p.? | 1 |
chr5:60050476-60050476 | p.G274V | 1 |
chr5:60067816-60067816 | p.E57K | 1 |
chr5:60053405-60053405 | p.G189G | 1 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 2 |   |   | 4 | 2 |   | 2 |   | 2 |   |   | 2 |   | 1 |   |   | 7 | 2 |   | 4 |
# mutation | 2 |   |   | 4 | 2 |   | 2 |   | 2 |   |   | 2 |   | 1 |   |   | 8 | 2 |   | 4 |
nonsynonymous SNV | 1 |   |   | 2 | 2 |   | 1 |   | 2 |   |   | 2 |   |   |   |   | 5 | 1 |   | 3 |
synonymous SNV | 1 |   |   | 2 |   |   | 1 |   |   |   |   |   |   | 1 |   |   | 3 | 1 |   | 1 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr5:60053414 | p.S186S,ELOVL7 | 2 |
chr5:60050591 | p.G194W,ELOVL7 | 1 |
chr5:60063651 | p.R59C,ELOVL7 | 1 |
chr5:60067911 | p.G189G,ELOVL7 | 1 |
chr5:60050614 | p.L41I,ELOVL7 | 1 |
chr5:60063670 | p.S32S,ELOVL7 | 1 |
chr5:60083198 | p.F172L,ELOVL7 | 1 |
chr5:60053392 | p.L30L,ELOVL7 | 1 |
chr5:60067734 | p.G170E,ELOVL7 | 1 |
chr5:60083202 | p.V25D,ELOVL7 | 1 |
Other DBs for Point Mutations |
Copy Number for ELOVL7 in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for ELOVL7 |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
ACSM1,AKR1D1,ALOX15B,B3GAT1,CLDN8,DEPDC1B,ELOVL7, HPGD,IDI1,ISX,KLHL31,LST-3TM12,NANOG,PNLIPRP3, RLN3,RNASE12,SCP2,SLCO1B1,SRD5A1,SULT1C3,UGT2B28 | ABCC12,ADCY10,AKR1D1,ALOX15B,C15orf43,CHRNA2,CTNNA2, DDC,ELOVL7,EPS8L3,HIST1H2AG,HPGD,IDI1,IYD, LST-3TM12,SERHL,SGPP2,SLC12A3,TMPRSS11F,UGT2B10,ZP2 |
AGR2,HID1,SLC18B1,CREB3L1,CYMP,ELOVL7,FAM57A, GATA6,GSTTP2,KDELR3,LMO4,LRRC16A,MAGEB10,PGM3, PLLP,POLD3,RBP3,REG4,RSPH1,SAP30,TSTA3 | CDH16,CEACAM18,CYP2J2,ELOVL7,F11,FABP2,GAL3ST1, GALNT6,MLXIPL,NAGS,PFKFB4,PNLIPRP2,SERPINA1,SLC13A2, SLC15A1,SLC30A2,SLC37A4,SLC6A19,TM4SF5,UGT2B7,UNC93A |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for ELOVL7 |
There's no related Drug. |
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Cross referenced IDs for ELOVL7 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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