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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for PTGES2 |
Basic gene info. | Gene symbol | PTGES2 |
Gene name | prostaglandin E synthase 2 | |
Synonyms | C9orf15|GBF-1|GBF1|PGES2|mPGES-2 | |
Cytomap | UCSC genome browser: 9q34.11 | |
Genomic location | chr9 :130882971-130890741 | |
Type of gene | protein-coding | |
RefGenes | NM_001256335.1, NM_025072.6,NM_198938.2,NM_198939.1,NM_198940.1, NR_027812.1, | |
Ensembl id | ENSG00000148334 | |
Description | GATE-binding factor 1gamma-interferon-activated transcriptional element-binding factor 1mPGE synthase-2membrane-associated prostaglandin E synthase 2membrane-associated prostaglandin E synthase-2microsomal prostaglandin E synthase-2prostaglandin-H(2 | |
Modification date | 20141207 | |
dbXrefs | MIM : 608152 | |
HGNC : HGNC | ||
Ensembl : ENSG00000148334 | ||
HPRD : 07458 | ||
Vega : OTTHUMG00000020730 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PTGES2 | |
BioGPS: 80142 | ||
Gene Expression Atlas: ENSG00000148334 | ||
The Human Protein Atlas: ENSG00000148334 | ||
Pathway | NCI Pathway Interaction Database: PTGES2 | |
KEGG: PTGES2 | ||
REACTOME: PTGES2 | ||
ConsensusPathDB | ||
Pathway Commons: PTGES2 | ||
Metabolism | MetaCyc: PTGES2 | |
HUMANCyc: PTGES2 | ||
Regulation | Ensembl's Regulation: ENSG00000148334 | |
miRBase: chr9 :130,882,971-130,890,741 | ||
TargetScan: NM_001256335 | ||
cisRED: ENSG00000148334 | ||
Context | iHOP: PTGES2 | |
cancer metabolism search in PubMed: PTGES2 | ||
UCL Cancer Institute: PTGES2 | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for PTGES2(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: PTGES2 |
Familial Cancer Database: PTGES2 |
* This gene is included in those cancer gene databases. |
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
KEGG_ARACHIDONIC_ACID_METABOLISM |
Others | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: PTGES2 |
MedGen: PTGES2 (Human Medical Genetics with Condition) | |
ClinVar: PTGES2 | |
Phenotype | MGI: PTGES2 (International Mouse Phenotyping Consortium) |
PhenomicDB: PTGES2 |
Mutations for PTGES2 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
There's no structural variation information in COSMIC data for this gene. |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows PTGES2 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
BG342124 | PTGES2 | 6 | 60 | 9 | 130889747 | 130889802 | PTGES2 | 59 | 729 | 9 | 130885212 | 130889772 |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
There's no copy number variation information in COSMIC data for this gene. |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=14) | (# total SNVs=5) |
(# total SNVs=0) | (# total SNVs=1) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr9:130885211-130885211 | p.? | 2 |
chr9:130884681-130884681 | p.R322Q | 2 |
chr9:130885340-130885340 | p.P254S | 1 |
chr9:130883435-130883435 | p.P375S | 1 |
chr9:130887694-130887694 | p.L102L | 1 |
chr9:130884744-130884744 | p.D301G | 1 |
chr9:130885353-130885359 | p.P248fs*94 | 1 |
chr9:130883442-130883442 | p.E372E | 1 |
chr9:130887715-130887716 | p.L96fs*8 | 1 |
chr9:130884753-130884753 | p.R298H | 1 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 2 |   |   | 3 |   |   | 1 |   |   |   |   |   | 2 | 1 |   |   | 3 | 4 | 1 | 3 |
# mutation | 3 |   |   | 2 |   |   | 1 |   |   |   |   |   | 2 | 1 |   |   | 3 | 3 | 1 | 3 |
nonsynonymous SNV | 2 |   |   | 1 |   |   | 1 |   |   |   |   |   |   | 1 |   |   | 1 | 2 | 1 | 3 |
synonymous SNV | 1 |   |   | 1 |   |   |   |   |   |   |   |   | 2 |   |   |   | 2 | 1 |   |   |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr9:130883508 | p.F350F,PTGES2 | 2 |
chr9:130884681 | p.R322Q,PTGES2 | 2 |
chr9:130886072 | p.A92A | 1 |
chr9:130883534 | p.R342C,PTGES2 | 1 |
chr9:130886805 | p.T75T | 1 |
chr9:130884666 | p.G327D,PTGES2 | 1 |
chr9:130887585 | p.V318G,PTGES2 | 1 |
chr9:130887690 | p.L293L,PTGES2 | 1 |
chr9:130884693 | p.L288V,PTGES2 | 1 |
chr9:130887694 | p.A283V,PTGES2 | 1 |
Other DBs for Point Mutations |
Copy Number for PTGES2 in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for PTGES2 |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
AURKAIP1,UQCC3,C19orf60,C9orf142,C9orf16,RABL6,CCDC124, DOHH,EDF1,GADD45GIP1,NTMT1,NDUFA11,NDUFB7,PMPCA, PTGES2,REXO4,RPL35,RPS19BP1,SSNA1,SURF2,TIMM13 | ADRM1,ATP5D,RABL6,ESRRA,EMC9,FAM195A,FASTK, CPTP,MAP2K2,NTMT1,MRPL12,MRPL14,NDUFA13,NDUFV1, NOSIP,PCBP4,PHPT1,PMF1,PTGES2,STK11,TIMM17B |
ATP5D,AURKAIP1,UQCC3,C9orf142,COQ4,ENDOG,FPGS, NTMT1,MRPL12,MRPL41,MRPS2,MRPS5,NDUFV1,PMPCA, PTGES2,PTRH1,SLC25A10,TUBB4B,UBAC1,WDR34,ZMYND19 | APEH,ASL,AURKAIP1,CDK2AP2,CYBA,DUS1L,SLC52A2, LMAN2,MAEA,MRPL12,MRPS34,NDUFS6,NDUFS7,NDUFV1, PTGES2,SLC25A10,SLC25A39,TIMM13,TLCD1,TUFM,UQCRC1 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for PTGES2 |
There's no related Drug. |
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Cross referenced IDs for PTGES2 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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