Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for PTGES2
Basic gene info.Gene symbolPTGES2
Gene nameprostaglandin E synthase 2
SynonymsC9orf15|GBF-1|GBF1|PGES2|mPGES-2
CytomapUCSC genome browser: 9q34.11
Genomic locationchr9 :130882971-130890741
Type of geneprotein-coding
RefGenesNM_001256335.1,
NM_025072.6,NM_198938.2,NM_198939.1,NM_198940.1,
NR_027812.1,
Ensembl idENSG00000148334
DescriptionGATE-binding factor 1gamma-interferon-activated transcriptional element-binding factor 1mPGE synthase-2membrane-associated prostaglandin E synthase 2membrane-associated prostaglandin E synthase-2microsomal prostaglandin E synthase-2prostaglandin-H(2
Modification date20141207
dbXrefs MIM : 608152
HGNC : HGNC
Ensembl : ENSG00000148334
HPRD : 07458
Vega : OTTHUMG00000020730
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PTGES2
BioGPS: 80142
Gene Expression Atlas: ENSG00000148334
The Human Protein Atlas: ENSG00000148334
PathwayNCI Pathway Interaction Database: PTGES2
KEGG: PTGES2
REACTOME: PTGES2
ConsensusPathDB
Pathway Commons: PTGES2
MetabolismMetaCyc: PTGES2
HUMANCyc: PTGES2
RegulationEnsembl's Regulation: ENSG00000148334
miRBase: chr9 :130,882,971-130,890,741
TargetScan: NM_001256335
cisRED: ENSG00000148334
ContextiHOP: PTGES2
cancer metabolism search in PubMed: PTGES2
UCL Cancer Institute: PTGES2
Assigned class in ccmGDBC

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Phenotypic Information for PTGES2(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: PTGES2
Familial Cancer Database: PTGES2
* This gene is included in those cancer gene databases.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_ARACHIDONIC_ACID_METABOLISM

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: PTGES2
MedGen: PTGES2 (Human Medical Genetics with Condition)
ClinVar: PTGES2
PhenotypeMGI: PTGES2 (International Mouse Phenotyping Consortium)
PhenomicDB: PTGES2

Mutations for PTGES2
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows PTGES2 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
BG342124PTGES26609130889747130889802PTGES2597299130885212130889772

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=2

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=14)
Stat. for Synonymous SNVs
(# total SNVs=5)
Stat. for Deletions
(# total SNVs=0)
Stat. for Insertions
(# total SNVs=1)
There's no deleted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr9:130885211-130885211p.?2
chr9:130884681-130884681p.R322Q2
chr9:130883434-130883434p.P375Q1
chr9:130887690-130887690p.L104L1
chr9:130884742-130884742p.N302Y1
chr9:130885340-130885340p.P254S1
chr9:130883435-130883435p.P375S1
chr9:130887694-130887694p.L102L1
chr9:130884744-130884744p.D301G1
chr9:130885353-130885359p.P248fs*941

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample2  3  1     21  3413
# mutation3  2  1     21  3313
nonsynonymous SNV2  1  1      1  1213
synonymous SNV1  1        2   21  
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr9:130883508p.F350F,PTGES22
chr9:130884681p.R322Q,PTGES22
chr9:130883435p.L104L1
chr9:130886051p.P375S,PTGES21
chr9:130886072p.L102L1
chr9:130883534p.A92A1
chr9:130886805p.R342C,PTGES21
chr9:130884666p.T75T1
chr9:130887585p.G327D,PTGES21
chr9:130887690p.V318G,PTGES21

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for PTGES2 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for PTGES2

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

AURKAIP1,UQCC3,C19orf60,C9orf142,C9orf16,RABL6,CCDC124,
DOHH,EDF1,GADD45GIP1,NTMT1,NDUFA11,NDUFB7,PMPCA,
PTGES2,REXO4,RPL35,RPS19BP1,SSNA1,SURF2,TIMM13
ADRM1,ATP5D,RABL6,ESRRA,EMC9,FAM195A,FASTK,
CPTP,MAP2K2,NTMT1,MRPL12,MRPL14,NDUFA13,NDUFV1,
NOSIP,PCBP4,PHPT1,PMF1,PTGES2,STK11,TIMM17B

ATP5D,AURKAIP1,UQCC3,C9orf142,COQ4,ENDOG,FPGS,
NTMT1,MRPL12,MRPL41,MRPS2,MRPS5,NDUFV1,PMPCA,
PTGES2,PTRH1,SLC25A10,TUBB4B,UBAC1,WDR34,ZMYND19
APEH,ASL,AURKAIP1,CDK2AP2,CYBA,DUS1L,SLC52A2,
LMAN2,MAEA,MRPL12,MRPS34,NDUFS6,NDUFS7,NDUFV1,
PTGES2,SLC25A10,SLC25A39,TIMM13,TLCD1,TUFM,UQCRC1
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for PTGES2


There's no related Drug.
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Cross referenced IDs for PTGES2
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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