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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for COASY |
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Phenotypic Information for COASY(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: COASY |
Familial Cancer Database: COASY |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS |
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OMIM | |
Orphanet | |
Disease | KEGG Disease: COASY |
MedGen: COASY (Human Medical Genetics with Condition) | |
ClinVar: COASY | |
Phenotype | MGI: COASY (International Mouse Phenotyping Consortium) |
PhenomicDB: COASY |
Mutations for COASY |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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There's no structural variation information in COSMIC data for this gene. |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows COASY related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
AI650663 | COASY | 12 | 126 | 17 | 40718187 | 40718301 | PPAN | 120 | 378 | 19 | 10220859 | 10221276 | |
BP275946 | COASY | 1 | 437 | 17 | 40714169 | 40714997 | LOC100507412 | 430 | 499 | ? | 109705 | 109774 | |
DC383781 | TAF1D | 1 | 64 | 11 | 93465527 | 93465590 | COASY | 65 | 563 | 17 | 40714169 | 40714791 | |
BG120370 | COASY | 1 | 61 | 17 | 40716721 | 40716794 | COASY | 52 | 757 | 17 | 40716816 | 40718145 | |
BE252620 | COASY | 1 | 266 | 17 | 40716570 | 40717050 | DTD1 | 264 | 586 | 20 | 18576749 | 18725309 | |
BQ212022 | COASY | 14 | 115 | 17 | 40716721 | 40716835 | COASY | 106 | 849 | 17 | 40716816 | 40718161 | |
CR739363 | COASY | 1 | 194 | 17 | 40714187 | 40714380 | PPAN | 189 | 483 | 19 | 10218787 | 10220884 |
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There's no copy number variation information in COSMIC data for this gene. |
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Stat. for Non-Synonymous SNVs (# total SNVs=35) | (# total SNVs=11) |
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(# total SNVs=2) | (# total SNVs=1) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr17:40714723-40714723 | p.S28L | 3 |
chr17:40716022-40716022 | p.V248V | 2 |
chr17:40714959-40714959 | p.L107F | 2 |
chr17:40716901-40716901 | p.E408Q | 2 |
chr17:40714961-40714961 | p.L107L | 2 |
chr17:40715065-40715067 | p.C144delC | 1 |
chr17:40717055-40717055 | p.F431C | 1 |
chr17:40717751-40717751 | p.S520S | 1 |
chr17:40714751-40714752 | p.Y38fs*26 | 1 |
chr17:40716755-40716755 | p.Y359S | 1 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 2 | 3 | 2 | 5 |   |   | 2 |   | 3 | 1 |   | 7 | 3 | 2 |   | 1 | 3 | 2 |   | 10 |
# mutation | 2 | 3 | 2 | 4 |   |   | 2 |   | 3 | 1 |   | 7 | 3 | 2 |   | 1 | 3 | 2 |   | 11 |
nonsynonymous SNV | 1 | 2 | 1 | 3 |   |   | 1 |   | 2 |   |   | 6 | 1 | 2 |   |   | 2 | 1 |   | 10 |
synonymous SNV | 1 | 1 | 1 | 1 |   |   | 1 |   | 1 | 1 |   | 1 | 2 |   |   | 1 | 1 | 1 |   | 1 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr17:40716755 | p.Y359C,COASY | 2 |
chr17:40717718 | p.A509A,COASY | 2 |
chr17:40717048 | p.R429W,COASY | 2 |
chr17:40715174 | p.P98P,COASY | 1 |
chr17:40714858 | p.R322K,COASY | 1 |
chr17:40717061 | p.A472S,COASY | 1 |
chr17:40715230 | p.L107F,COASY | 1 |
chr17:40716772 | p.G342E,COASY | 1 |
chr17:40714916 | p.L506L,COASY | 1 |
chr17:40717259 | p.P111T,COASY | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for COASY |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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AARSD1,ACBD4,BECN1,CCDC103,COA3,CHCHD5,COASY, FAM134C,G6PC3,GAMT,GHDC,HEXIM2,KAT2A,KRT19, NAGLU,PLEKHH3,RAB5C,SLC25A39,STK16,TMUB2,VPS25 | ARRDC1,ATP13A1,ATP13A2,HID1,C9orf114,CACFD1,COASY, COMT,COQ4,DAK,DUS1L,FUK,GAK,GSS, IGSF8,LLGL2,NARFL,NDOR1,PAK4,PICK1,SGSM3 | ||||
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AARSD1,CCDC137,CDC6,COASY,DBF4B,DUS1L,EFTUD2, ERAL1,GIT1,GPS1,KAT2A,MLX,MRM1,PNPO, POLDIP2,SLC25A19,SLC25A39,SMARCD2,TSEN54,TUBG1,VPS25 | ABCF3,AP1M2,APEH,APEX2,ARHGEF16,CKMT1B,COASY, E2F2,FBXL6,SLC52A2,IRAK1,LEMD2,PITPNM1,SH3BP1, SLC25A10,SMARCD2,STXBP2,TALDO1,TLCD1,TTLL12,USP43 |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for COASY |
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DB Category | DB Name | DB's ID and Url link |
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* Gene Centered Interaction Network. |
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* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB00151 | CoA synthase | approved; nutraceutical | L-Cysteine | ![]() | ![]() |
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Cross referenced IDs for COASY |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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