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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for ACOX2 |
Basic gene info. | Gene symbol | ACOX2 |
Gene name | acyl-CoA oxidase 2, branched chain | |
Synonyms | BCOX|BRCACOX|BRCOX|THCCox | |
Cytomap | UCSC genome browser: 3p14.3 | |
Genomic location | chr3 :58490862-58522929 | |
Type of gene | protein-coding | |
RefGenes | NM_003500.3, | |
Ensembl id | ENSG00000168306 | |
Description | 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidaseTHCA-CoA oxidaseacyl-Coenzyme A oxidase 2, branched chainperoxisomal acyl-coenzyme A oxidase 2peroxisomal bra | |
Modification date | 20141207 | |
dbXrefs | MIM : 601641 | |
HGNC : HGNC | ||
Ensembl : ENSG00000168306 | ||
HPRD : 09037 | ||
Vega : OTTHUMG00000159154 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ACOX2 | |
BioGPS: 8309 | ||
Gene Expression Atlas: ENSG00000168306 | ||
The Human Protein Atlas: ENSG00000168306 | ||
Pathway | NCI Pathway Interaction Database: ACOX2 | |
KEGG: ACOX2 | ||
REACTOME: ACOX2 | ||
ConsensusPathDB | ||
Pathway Commons: ACOX2 | ||
Metabolism | MetaCyc: ACOX2 | |
HUMANCyc: ACOX2 | ||
Regulation | Ensembl's Regulation: ENSG00000168306 | |
miRBase: chr3 :58,490,862-58,522,929 | ||
TargetScan: NM_003500 | ||
cisRED: ENSG00000168306 | ||
Context | iHOP: ACOX2 | |
cancer metabolism search in PubMed: ACOX2 | ||
UCL Cancer Institute: ACOX2 | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for ACOX2(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: ACOX2 |
Familial Cancer Database: ACOX2 |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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REACTOME_PEROXISOMAL_LIPID_METABOLISM REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS |
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OMIM | |
Orphanet | |
Disease | KEGG Disease: ACOX2 |
MedGen: ACOX2 (Human Medical Genetics with Condition) | |
ClinVar: ACOX2 | |
Phenotype | MGI: ACOX2 (International Mouse Phenotyping Consortium) |
PhenomicDB: ACOX2 |
Mutations for ACOX2 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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There's no structural variation information in COSMIC data for this gene. |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ACOX2 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
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Mutation type/ Tissue ID | brca | cns | cerv | endome | haematopo | kidn | Lintest | liver | lung | ns | ovary | pancre | prost | skin | stoma | thyro | urina | |||
Total # sample |   |   |   |   |   |   |   |   |   |   | 1 |   |   |   |   |   |   | |||
GAIN (# sample) |   |   |   |   |   |   |   |   |   |   | 1 |   |   |   |   |   |   | |||
LOSS (# sample) |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract) |
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Stat. for Non-Synonymous SNVs (# total SNVs=34) | (# total SNVs=19) |
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(# total SNVs=4) | (# total SNVs=0) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr3:58512309-58512309 | p.R410S | 2 |
chr3:58510265-58510266 | p.P472fs*9 | 2 |
chr3:58512375-58512375 | p.A388A | 2 |
chr3:58490979-58490979 | p.L673P | 2 |
chr3:58519830-58519830 | p.F122F | 2 |
chr3:58520786-58520786 | p.R16R | 2 |
chr3:58516206-58516206 | p.R327W | 2 |
chr3:58519737-58519740 | p.T154fs*25 | 1 |
chr3:58516239-58516239 | p.A316S | 1 |
chr3:58520251-58520251 | p.? | 1 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 2 | 1 | 1 | 7 | 2 |   | 3 |   | 2 | 2 |   | 5 | 2 |   |   |   | 9 | 7 |   | 11 |
# mutation | 2 | 1 | 1 | 7 | 2 |   | 3 |   | 2 | 2 |   | 5 | 2 |   |   |   | 9 | 7 |   | 12 |
nonsynonymous SNV | 2 | 1 |   | 5 | 1 |   | 1 |   | 1 | 1 |   | 4 | 1 |   |   |   | 6 | 4 |   | 7 |
synonymous SNV |   |   | 1 | 2 | 1 |   | 2 |   | 1 | 1 |   | 1 | 1 |   |   |   | 3 | 3 |   | 5 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr3:58519830 | p.F122F | 2 |
chr3:58514651 | p.V515L | 1 |
chr3:58519189 | p.N377N | 1 |
chr3:58503042 | p.H181Y | 1 |
chr3:58510295 | p.I511M | 1 |
chr3:58519857 | p.L347L | 1 |
chr3:58514681 | p.V179E | 1 |
chr3:58519210 | p.T501M | 1 |
chr3:58508254 | p.T342I | 1 |
chr3:58510329 | p.T175N | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for ACOX2 |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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ABAT,ACOX2,ADAMTSL5,AP3S1,ATG12,LINC00467,C9orf116, CAPN13,DSCR8,FOXA1,KCNS3,KCTD6,MST1R,NFKBIZ, PCGEM1,PDHB,PFKFB3,PRKCD,RBKS,SLC22A18,TMEM63C | ACO1,ACOX2,ALDH2,AOC3,CALB2,CIDEC,DGAT1, FAH,GPD1,GYG2,HEPACAM,HEPN1,LIPE,NDN, PEX19,PJA1,PLIN1,RDH5,TSPAN3,TYRO3,VTI1B | ||||
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ACOX2,ACSL6,TRABD2A,CRB2,CYP39A1,ENPP3,GRM8, ISX,NR1I2,QPRT,RXFP4,SHROOM1,SLC39A5,SPHK2, STAP2,SUOX,TDGF1,TDGF1P3,TMEM211,TMEM63C,USH1C | ACOX2,ATRN,BTD,ADIRF,EEPD1,ESRRG,EXOC6B, GNB1,HEBP1,HOXC11,HOXC6,MAOB,MATN2,MARC2, NELL2,PGRMC2,PPP2R5D,SCAPER,STAU2,TMEM117,TMEM25 |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for ACOX2 |
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DB Category | DB Name | DB's ID and Url link |
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* Gene Centered Interaction Network. |
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* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB00145 | acyl-CoA oxidase 2, branched chain | approved; nutraceutical | Glycine | ![]() | ![]() |
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Cross referenced IDs for ACOX2 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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