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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for DOHH |
Basic gene info. | Gene symbol | DOHH |
Gene name | deoxyhypusine hydroxylase/monooxygenase | |
Synonyms | HLRC1|hDOHH | |
Cytomap | UCSC genome browser: 19p13.3 | |
Genomic location | chr19 :3490818-3500621 | |
Type of gene | protein-coding | |
RefGenes | NM_001145165.1, NM_031304.4, | |
Ensembl id | ENSG00000129932 | |
Description | HEAT-like (PBS lyase) repeat containing 1HEAT-like repeat-containing protein 1deoxyhypusine dioxygenasedeoxyhypusine hydroxylasedeoxyhypusine monooxygenase | |
Modification date | 20141207 | |
dbXrefs | MIM : 611262 | |
HGNC : HGNC | ||
Ensembl : ENSG00000129932 | ||
HPRD : 14627 | ||
Vega : OTTHUMG00000180762 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_DOHH | |
BioGPS: 83475 | ||
Gene Expression Atlas: ENSG00000129932 | ||
The Human Protein Atlas: ENSG00000129932 | ||
Pathway | NCI Pathway Interaction Database: DOHH | |
KEGG: DOHH | ||
REACTOME: DOHH | ||
ConsensusPathDB | ||
Pathway Commons: DOHH | ||
Metabolism | MetaCyc: DOHH | |
HUMANCyc: DOHH | ||
Regulation | Ensembl's Regulation: ENSG00000129932 | |
miRBase: chr19 :3,490,818-3,500,621 | ||
TargetScan: NM_001145165 | ||
cisRED: ENSG00000129932 | ||
Context | iHOP: DOHH | |
cancer metabolism search in PubMed: DOHH | ||
UCL Cancer Institute: DOHH | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for DOHH(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: DOHH |
Familial Cancer Database: DOHH |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
REACTOME_METABOLISM_OF_PROTEINS |
Others | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: DOHH |
MedGen: DOHH (Human Medical Genetics with Condition) | |
ClinVar: DOHH | |
Phenotype | MGI: DOHH (International Mouse Phenotyping Consortium) |
PhenomicDB: DOHH |
Mutations for DOHH |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
There's no structural variation information in COSMIC data for this gene. |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows DOHH related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
There's no copy number variation information in COSMIC data for this gene. |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=12) | (# total SNVs=5) |
(# total SNVs=1) | (# total SNVs=0) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr19:3496805-3496805 | p.T3M | 2 |
chr19:3491733-3491733 | p.V222V | 2 |
chr19:3496736-3496736 | p.R26Q | 2 |
chr19:3492397-3492397 | p.P151L | 1 |
chr19:3496774-3496774 | p.T13T | 1 |
chr19:3494028-3494028 | p.E117* | 1 |
chr19:3496777-3496777 | p.Q12H | 1 |
chr19:3494053-3494053 | p.K108K | 1 |
chr19:3496787-3496787 | p.A9V | 1 |
chr19:3494071-3494071 | p.E102E | 1 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample |   |   |   | 2 |   |   | 1 |   |   |   |   |   |   |   |   |   |   | 4 |   |   |
# mutation |   |   |   | 2 |   |   | 2 |   |   |   |   |   |   |   |   |   |   | 4 |   |   |
nonsynonymous SNV |   |   |   | 1 |   |   | 1 |   |   |   |   |   |   |   |   |   |   | 3 |   |   |
synonymous SNV |   |   |   | 1 |   |   | 1 |   |   |   |   |   |   |   |   |   |   | 1 |   |   |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr19:3496774 | p.R156H,DOHH | 1 |
chr19:3496787 | p.L107L,DOHH | 1 |
chr19:3496805 | p.E102K,DOHH | 1 |
chr19:3492382 | p.Q79Q,DOHH | 1 |
chr19:3494056 | p.S51P,DOHH | 1 |
chr19:3494073 | p.D48N,DOHH | 1 |
chr19:3496576 | p.T13T,DOHH | 1 |
chr19:3496662 | p.A9D,DOHH | 1 |
chr19:3496671 | p.T3M,DOHH | 1 |
Other DBs for Point Mutations |
Copy Number for DOHH in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for DOHH |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
CACTIN,C19orf60,C19orf70,CCDC124,CDC34,DAPK3,DOHH, ABHD17A,HDGFRP2,KLF16,LSM7,MAP2K2,MBD3,NCLN, NDUFS7,PLEKHJ1,POLRMT,SGTA,SIRT6,TIMM13,WDR18 | ALDH16A1,ARFRP1,ASPSCR1,C19orf60,FAM207A,CCDC124,DOHH, MZT2B,FAM173A,GADD45GIP1,GIPC1,HDGFRP2,MBD3,NFKBIB, NUBP2,OGFR,RBM42,SCAF1,TMUB1,ZNF428,ZNF787 |
ADAT3,CACTIN,CCDC124,DAZAP1,DOHH,ELAVL1,FZR1, HDGFRP2,KLF16,LONP1,MBD3,NCLN,POLRMT,PPAN, RAVER1,REXO1,SAFB,SGTA,STK11,THOP1,TOMM40 | CCDC9,DAZAP1,DDX54,DHX37,DIS3L2,DOHH,EIF3B, ELAVL1,FBXL19,HNRNPA0,HNRNPM,KHSRP,CLUH,LONP1, MBD3,MYBBP1A,NOC2L,SAFB,TELO2,TMEM201,VARS |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for DOHH |
There's no related Drug. |
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Cross referenced IDs for DOHH |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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