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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for UCK1 |
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Phenotypic Information for UCK1(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: UCK1 |
Familial Cancer Database: UCK1 |
* This gene is included in those cancer gene databases. |
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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KEGG_PYRIMIDINE_METABOLISM KEGG_DRUG_METABOLISM_OTHER_ENZYMES REACTOME_METABOLISM_OF_NUCLEOTIDES REACTOME_PYRIMIDINE_METABOLISM |
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OMIM | |
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Disease | KEGG Disease: UCK1 |
MedGen: UCK1 (Human Medical Genetics with Condition) | |
ClinVar: UCK1 | |
Phenotype | MGI: UCK1 (International Mouse Phenotyping Consortium) |
PhenomicDB: UCK1 |
Mutations for UCK1 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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There's no structural variation information in COSMIC data for this gene. |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows UCK1 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
BF203809 | BRSK1 | 2 | 273 | 19 | 55795898 | 55800890 | UCK1 | 269 | 689 | 9 | 134404397 | 134406032 |
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There's no copy number variation information in COSMIC data for this gene. |
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Stat. for Non-Synonymous SNVs (# total SNVs=17) | (# total SNVs=8) |
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(# total SNVs=1) | (# total SNVs=1) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr9:134406559-134406559 | p.M1I | 2 |
chr9:134401335-134401335 | p.P211P | 2 |
chr9:134400533-134400533 | p.S243F | 2 |
chr9:134404407-134404407 | p.R176L | 2 |
chr9:134404419-134404419 | p.R172Q | 1 |
chr9:134404928-134404928 | p.I104I | 1 |
chr9:134400586-134400586 | p.Q225Q | 1 |
chr9:134406551-134406551 | p.A4V | 1 |
chr9:134404515-134404515 | p.V170I | 1 |
chr9:134404931-134404931 | p.N103N | 1 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample |   |   |   | 2 | 1 |   | 2 |   | 1 | 1 |   |   |   |   |   |   | 4 | 4 |   | 9 |
# mutation |   |   |   | 2 | 1 |   | 2 |   | 1 | 1 |   |   |   |   |   |   | 4 | 5 |   | 9 |
nonsynonymous SNV |   |   |   |   | 1 |   | 2 |   | 1 |   |   |   |   |   |   |   | 2 | 3 |   | 7 |
synonymous SNV |   |   |   | 2 |   |   |   |   |   | 1 |   |   |   |   |   |   | 2 | 2 |   | 2 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr9:134404542 | p.D161N,UCK1 | 2 |
chr9:134404931 | p.D170N,UCK1 | 1 |
chr9:134404388 | p.S37P,UCK1 | 1 |
chr9:134404932 | p.L37P | 1 |
chr9:134404410 | p.T160T,UCK1 | 1 |
chr9:134404963 | p.I148T,UCK1 | 1 |
chr9:134404515 | p.E125E,UCK1 | 1 |
chr9:134404971 | p.L123L,UCK1 | 1 |
chr9:134405877 | p.P113P,UCK1 | 1 |
chr9:134404543 | p.I104I,UCK1 | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for UCK1 |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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ANAPC2,C9orf114,C9orf142,ARRDC1-AS1,RABL6,NELFB,COQ4, DPM2,EDF1,MRPL41,NDOR1,PHPT1,POMT1,PPP2R4, PTGES2,REXO4,SSNA1,SURF2,UCK1,URM1,USP20 | BOLA1,TSR3,CCDC106,CHMP2A,CPSF4,CTDSP1,EXOC3, FIS1,FKBP8,GRHPR,KLHL22,NDUFB7,PIN1,PSMC3, RPS19BP1,STUB1,THAP3,UBXN6,UCK1,USE1,WDR13 | ||||
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ANAPC2,ASB6,C9orf114,ARRDC1-AS1,C9orf69,C9orf78,NELFB, DOLK,INPP5E,LOC100272217,MAPKAP1,MED27,POMT1,SSNA1, TBC1D13,TMEM203,TOR1A,TRAF2,UCK1,URM1,USP20 | AIP,ARL3,FAM227B,C6orf1,CAMLG,CUEDC2,MANBAL, NINJ1,PPM1M,R3HCC1,RGS10,SIRT2,SNRPN,STOML1, TPD52L2,UBL4A,UCK1,UROD,ZC3H10,ZMAT5,ZNF691 |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for UCK1 |
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DB Category | DB Name | DB's ID and Url link |
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* Gene Centered Interaction Network. |
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* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB02745 | uridine-cytidine kinase 1 | experimental | Uridine | ![]() | ![]() |
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Cross referenced IDs for UCK1 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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