Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for MRI1
Basic gene info.Gene symbolMRI1
Gene namemethylthioribose-1-phosphate isomerase 1
SynonymsMRDI|MTNA|Ypr118w
CytomapUCSC genome browser: 19p13.2
Genomic locationchr19 :13875336-13885096
Type of geneprotein-coding
RefGenesNM_001031727.2,
NM_032285.2,
Ensembl idENSG00000037757
DescriptionM1PiMTR-1-P isomeraseS-methyl-5-thioribose-1-phosphate isomerase 1mediator of RhoA-dependent invasionmethylthioribose-1-phosphate isomerasemethylthioribose-1-phosphate isomerase homologtranslation initiation factor eIF-2B subunit alpha/beta/delta-li
Modification date20141207
dbXrefs MIM : 615105
HGNC : HGNC
Ensembl : ENSG00000037757
HPRD : 14548
Vega : OTTHUMG00000180867
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MRI1
BioGPS: 84245
Gene Expression Atlas: ENSG00000037757
The Human Protein Atlas: ENSG00000037757
PathwayNCI Pathway Interaction Database: MRI1
KEGG: MRI1
REACTOME: MRI1
ConsensusPathDB
Pathway Commons: MRI1
MetabolismMetaCyc: MRI1
HUMANCyc: MRI1
RegulationEnsembl's Regulation: ENSG00000037757
miRBase: chr19 :13,875,336-13,885,096
TargetScan: NM_001031727
cisRED: ENSG00000037757
ContextiHOP: MRI1
cancer metabolism search in PubMed: MRI1
UCL Cancer Institute: MRI1
Assigned class in ccmGDBC

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Phenotypic Information for MRI1(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: MRI1
Familial Cancer Database: MRI1
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
REACTOME_SULFUR_AMINO_ACID_METABOLISM
REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES
REACTOME_METABOLISM_OF_POLYAMINES

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: MRI1
MedGen: MRI1 (Human Medical Genetics with Condition)
ClinVar: MRI1
PhenotypeMGI: MRI1 (International Mouse Phenotyping Consortium)
PhenomicDB: MRI1

Mutations for MRI1
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows MRI1 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=3

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=13)
Stat. for Synonymous SNVs
(# total SNVs=7)
Stat. for Deletions
(# total SNVs=4)
Stat. for Insertions
(# total SNVs=0)
There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr19:13882968-13882968p.H330fs*244
chr19:13876915-13876915p.L173L3
chr19:13883024-13883024p.E347*2
chr19:13875456-13875456p.Q18H2
chr19:13879816-13879816p.P301P1
chr19:13876916-13876916p.A174S1
chr19:13879819-13879819p.G302G1
chr19:13876943-13876943p.G183C1
chr19:13882933-13882933p.?1
chr19:13879484-13879484p.E219D1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample   21 1    11  114 2
# mutation   21 1    11  114 2
nonsynonymous SNV   1  1    11  113  
synonymous SNV   11            1 2
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr19:13875456p.Q18H,MRI12
chr19:13879744p.G302G,MRI11
chr19:13879776p.H330H,MRI11
chr19:13879814p.E347D,MRI11
chr19:13879819p.D361N,MRI11
chr19:13882975p.E4D,MRI11
chr19:13875414p.L173L1
chr19:13883026p.P147P1
chr19:13883066p.R249H,MRI11
chr19:13876915p.D255N,MRI11

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for MRI1 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for MRI1

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

AKAP8,ANO8,C19orf44,CC2D1A,CCDC130,CHERP,CRTC1,
DCAF15,GTPBP3,HOOK2,KRI1,MED26,MRI1,RFX1,
SIN3B,STX10,TNPO2,TRMT1,TYK2,WIZ,ZNF700
ARHGAP33,BPNT1,ATAT1,TBC1D32,CDK20,FLJ45445,GK5,
HSD17B7P2,METTL17,MRI1,NSUN7,PABPC1L,PMS2,QPCTL,
SECISBP2,SNHG10,WDR73,ZNF266,ZNF273,ZNF433,ZNF785

ANKRD16,ANKRD49,ARMC6,C19orf60,C19orf70,DDX39A,DDX49,
DUS3L,DUSP28,LOC401588,MRI1,MRPL4,NDUFA11,NR2C2AP,
OGT,PNO1,QTRT1,ST20,TIA1,TRMT1,UBA2
AGAP4,AHSA2,ANKS3,APBB3,CALCR,CEP95,EFHC1,
IKBKB,MRI1,PAN2,POLM,RBM5,SNHG12,STAG3L1,
TBC1D3,THSD1P1,TRIM4,TRPV1,USPL1,ZNF75D,ZNF839
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for MRI1


There's no related Drug.
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Cross referenced IDs for MRI1
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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