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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for POLR3GL |
Basic gene info. | Gene symbol | POLR3GL |
Gene name | polymerase (RNA) III (DNA directed) polypeptide G (32kD)-like | |
Synonyms | RPC32HOM|flj32422 | |
Cytomap | UCSC genome browser: 1q21.1 | |
Genomic location | chr1 :145456235-145470387 | |
Type of gene | protein-coding | |
RefGenes | NM_032305.1, | |
Ensembl id | ENSG00000266741 | |
Description | DNA-directed RNA polymerase III subunit G-likeDNA-directed RNA polymerase III subunit RPC7-likeRNA polymerase III subunit C7-likeRPC32-like proteinalternative RNA polymerase III subunit 32 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000121851 | ||
HPRD : 14546 | ||
Vega : OTTHUMG00000013739 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_POLR3GL | |
BioGPS: 84265 | ||
Gene Expression Atlas: ENSG00000266741 | ||
The Human Protein Atlas: ENSG00000266741 | ||
Pathway | NCI Pathway Interaction Database: POLR3GL | |
KEGG: POLR3GL | ||
REACTOME: POLR3GL | ||
ConsensusPathDB | ||
Pathway Commons: POLR3GL | ||
Metabolism | MetaCyc: POLR3GL | |
HUMANCyc: POLR3GL | ||
Regulation | Ensembl's Regulation: ENSG00000266741 | |
miRBase: chr1 :145,456,235-145,470,387 | ||
TargetScan: NM_032305 | ||
cisRED: ENSG00000266741 | ||
Context | iHOP: POLR3GL | |
cancer metabolism search in PubMed: POLR3GL | ||
UCL Cancer Institute: POLR3GL | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for POLR3GL(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: POLR3GL |
Familial Cancer Database: POLR3GL |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
KEGG_PURINE_METABOLISM KEGG_PYRIMIDINE_METABOLISM |
Mutations for POLR3GL |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
There's no structural variation information in COSMIC data for this gene. |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows POLR3GL related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
Mutation type/ Tissue ID | brca | cns | cerv | endome | haematopo | kidn | Lintest | liver | lung | ns | ovary | pancre | prost | skin | stoma | thyro | urina | |||
Total # sample |   |   |   | 1 |   |   |   |   | 1 |   |   |   |   |   |   |   |   | |||
GAIN (# sample) |   |   |   | 1 |   |   |   |   | 1 |   |   |   |   |   |   |   |   | |||
LOSS (# sample) |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract) |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=16) | (# total SNVs=9) |
(# total SNVs=2) | (# total SNVs=0) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr1:145460201-145460201 | p.R8R | 3 |
chr1:145456645-145456645 | p.I217V | 2 |
chr1:145459666-145459666 | p.A81V | 2 |
chr1:145460103-145460103 | p.L40L | 1 |
chr1:145457548-145457548 | p.R128R | 1 |
chr1:145460115-145460115 | p.Q36Q | 1 |
chr1:145457582-145457582 | p.E116D | 1 |
chr1:145460184-145460184 | p.G13G | 1 |
chr1:145457935-145457935 | p.D109H | 1 |
chr1:145460194-145460194 | p.R10H | 1 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample |   | 4 |   | 2 |   |   |   |   |   |   |   |   | 1 |   |   |   |   |   |   | 4 |
# mutation |   | 4 |   | 2 |   |   |   |   |   |   |   |   | 1 |   |   |   |   |   |   | 4 |
nonsynonymous SNV |   | 3 |   | 2 |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   | 2 |
synonymous SNV |   | 1 |   |   |   |   |   |   |   |   |   |   | 1 |   |   |   |   |   |   | 2 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr1:145459652 | p.A81V | 1 |
chr1:145459666 | p.Q36Q | 1 |
chr1:145460115 | p.R10H | 1 |
chr1:145456652 | p.D214D | 1 |
chr1:145460194 | p.E182D | 1 |
chr1:145457015 | p.R128R | 1 |
chr1:145457308 | p.R128R | 1 |
chr1:145457548 | p.E116D | 1 |
chr1:145457582 | p.D109H | 1 |
chr1:145457935 | p.D105N | 1 |
Other DBs for Point Mutations |
Copy Number for POLR3GL in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for POLR3GL |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
COMMD6,GABARAP,GNAI2,ISCU,MVP,PBXIP1,PEX11B, PFDN5,PMF1,POLR3GL,PPM1M,RAB13,RILPL2,LAMTOR2, RRAS,SNAPIN,STX4,STX8,THYN1,TMEM219,TNFSF12 | ACAA2,ALDH2,ANXA6,ADIRF,C1orf123,CAMK1,CD99L2, GABARAPL1,GYPC,IAH1,INPP5K,NDN,PJA1,PLA2G16, POLR3GL,PPP1R1A,ST6GALNAC6,TMBIM1,EMC3,VEGFB,VTI1B |
AIDA,C10orf10,LINC00467,DISP1,FAM114A2,DENND6B,GABARAP, LIX1L,PBXIP1,PHF1,PIAS3,POLR3GL,RAB13,S100A13, SDC3,SLC27A1,TK2,TLR5,TNFSF12,TXNIP,ZNF438 | AMZ2P1,ARL3,BEX4,C11orf74,CDPF1,CBY1,COMMD6, ISCU,MEAF6,MRFAP1L1,MSTN,PAIP2,PCMTD1,POLR3GL, RAP1A,RGS10,ZFP2,ZNF415,ZNF433,ZNF626,ZNF691 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for POLR3GL |
There's no related Drug. |
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Cross referenced IDs for POLR3GL |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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