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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for TUBB6 |
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Phenotypic Information for TUBB6(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: TUBB6 |
Familial Cancer Database: TUBB6 |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
REACTOME_METABOLISM_OF_PROTEINS |
Others | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: TUBB6 |
MedGen: TUBB6 (Human Medical Genetics with Condition) | |
ClinVar: TUBB6 | |
Phenotype | MGI: TUBB6 (International Mouse Phenotyping Consortium) |
PhenomicDB: TUBB6 |
Mutations for TUBB6 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
- Statistics for Tissue and Mutation type | Top |
- For Inter-chromosomal Variations |
There's no inter-chromosomal structural variation. |
- For Intra-chromosomal Variations |
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'. |
Sample | Symbol_a | Chr_a | Start_a | End_a | Symbol_b | Chr_b | Start_b | End_b |
pancreas | TUBB6 | chr18 | 12315240 | 12315260 | TUBB6 | chr18 | 12315952 | 12315972 |
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract) |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows TUBB6 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
BU927907 | IL4I1 | 3 | 229 | 19 | 50410779 | 50411007 | TUBB6 | 224 | 429 | 18 | 12326345 | 12326549 | |
BF095880 | ADI1 | 1 | 432 | 2 | 3502501 | 3504659 | TUBB6 | 429 | 487 | 18 | 12326076 | 12326134 | |
AA416878 | RYR2 | 134 | 155 | 1 | 237787094 | 237787116 | TUBB6 | 152 | 496 | 18 | 12324898 | 12325242 |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
There's no copy number variation information in COSMIC data for this gene. |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=22) | (# total SNVs=16) |
(# total SNVs=0) | (# total SNVs=0) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr18:12325590-12325590 | p.P268S | 2 |
chr18:12326037-12326037 | p.D417N | 2 |
chr18:12308793-12308793 | p.S55S | 2 |
chr18:12325685-12325685 | p.M299I | 2 |
chr18:12326001-12326001 | p.E405K | 2 |
chr18:12308711-12308711 | p.H28R | 1 |
chr18:12325072-12325072 | p.T95M | 1 |
chr18:12325740-12325740 | p.R318C | 1 |
chr18:12325410-12325410 | p.Y208H | 1 |
chr18:12326006-12326006 | p.M406I | 1 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 2 | 1 |   | 7 |   |   | 4 |   | 1 |   |   | 3 | 1 |   |   |   | 7 | 10 |   | 9 |
# mutation | 2 | 1 |   | 8 |   |   | 4 |   | 1 |   |   | 3 | 1 |   |   |   | 8 | 11 |   | 9 |
nonsynonymous SNV | 2 | 1 |   | 4 |   |   | 3 |   | 1 |   |   |   |   |   |   |   | 7 | 7 |   | 5 |
synonymous SNV |   |   |   | 4 |   |   | 1 |   |   |   |   | 3 | 1 |   |   |   | 1 | 4 |   | 4 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr18:12326037 | p.P268S | 2 |
chr18:12325590 | p.D417N | 2 |
chr18:12308734 | p.Y36H | 1 |
chr18:12325656 | p.P173L | 1 |
chr18:12325201 | p.T290A | 1 |
chr18:12325960 | p.E45K | 1 |
chr18:12325518 | p.E205K | 1 |
chr18:12308761 | p.D295N | 1 |
chr18:12325671 | p.A63A | 1 |
chr18:12325202 | p.Y208H | 1 |
Other DBs for Point Mutations |
Copy Number for TUBB6 in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for TUBB6 |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
ARHGAP22,B4GALT2,BATF3,BRI3,PXDC1,CDC42EP1,FHL3, KIFC3,LMNA,MICALL1,NXN,PDLIM7,PIM1,PLAUR, PLSCR3,PRKCDBP,PTRF,S100A10,TPM2,TUBB6,VIM | AP1M1,ADIRF,CCDC107,CD81,EHD2,FNDC4,HABP4, LGALS1,NUMBL,PALM,PNMA1,PRR5,PTRF,RRAS, SURF4,TESK1,TFE3,TPD52L2,TUBB6,VEGFB,VIM |
AMOTL1,BNC2,CNRIP1,COPZ2,DPYSL3,EFEMP2,EFS, EHD2,EMILIN1,FBXL7,FERMT2,FEZ1,GLI3,GYPC, LAYN,MRAS,PDLIM7,PLEKHO1,PTRF,RAB34,TUBB6 | BVES,CALD1,CSRP1,DNAJB5,DPYSL3,FERMT2,ITGB1BP2, LOC401093,MSRB3,MYLK,NCS1,PDLIM3,PDLIM4,PDLIM7, PTRF,SYNPO2,TPM1,TPM2,TSPAN2,TUBA1A,TUBB6 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for TUBB6 |
There's no related Drug. |
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Cross referenced IDs for TUBB6 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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