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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for MCEE |
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Phenotypic Information for MCEE(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: MCEE |
Familial Cancer Database: MCEE |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
KEGG_PROPANOATE_METABOLISM REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS |
Others | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: MCEE |
MedGen: MCEE (Human Medical Genetics with Condition) | |
ClinVar: MCEE | |
Phenotype | MGI: MCEE (International Mouse Phenotyping Consortium) |
PhenomicDB: MCEE |
Mutations for MCEE |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
There's no structural variation information in COSMIC data for this gene. |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows MCEE related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
DR980649 | MCEE | 1 | 161 | 2 | 71351563 | 71357359 | METTL8 | 157 | 217 | 2 | 172180339 | 172180849 |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
There's no copy number variation information in COSMIC data for this gene. |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=15) | (# total SNVs=1) |
(# total SNVs=4) | (# total SNVs=0) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr2:71337212-71337212 | p.K140fs*6 | 4 |
chr2:71351338-71351338 | p.E126K | 3 |
chr2:71351574-71351574 | p.R47Q | 2 |
chr2:71337226-71337226 | p.M135I | 1 |
chr2:71351487-71351487 | p.A76V | 1 |
chr2:71351507-71351508 | p.L69>? | 1 |
chr2:71351373-71351373 | p.K114R | 1 |
chr2:71351516-71351516 | p.K66N | 1 |
chr2:71351378-71351378 | p.L112L | 1 |
chr2:71351523-71351523 | p.F64Y | 1 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 1 |   |   | 2 |   |   |   |   |   |   |   | 2 | 1 | 1 |   |   | 2 | 3 |   | 1 |
# mutation | 1 |   |   | 2 |   |   |   |   |   |   |   | 2 | 1 | 1 |   |   | 2 | 3 |   | 1 |
nonsynonymous SNV | 1 |   |   | 2 |   |   |   |   |   |   |   | 2 | 1 |   |   |   | 1 | 2 |   | 1 |
synonymous SNV |   |   |   |   |   |   |   |   |   |   |   |   |   | 1 |   |   | 1 | 1 |   |   |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr2:71351415 | p.H82Y | 1 |
chr2:71351470 | p.A76A | 1 |
chr2:71351486 | p.K66N | 1 |
chr2:71351516 | p.F64Y | 1 |
chr2:71351523 | p.S41Y | 1 |
chr2:71337190 | p.A8A | 1 |
chr2:71351592 | p.E147D | 1 |
chr2:71337204 | p.R143C | 1 |
chr2:71357326 | p.L137F | 1 |
chr2:71337220 | p.E126K | 1 |
Other DBs for Point Mutations |
Copy Number for MCEE in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for MCEE |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
ANAPC13,C11orf1,ATRAID,COA5,NMRK1,CDNF,EIF4EBP3, FLJ36777,LYRM1,MCEE,MGST2,NDUFV2,NFU1,OCIAD1, PIGH,PIGV,REEP5,SPCS1,UNC50,VIPR1,ZCWPW2 | ANAPC16,ATP5S,AUH,MPC1,GHITM,GPN3,KLHDC2, LACTB2,MCEE,MNAT1,MRPL39,MRPS10,MRPS22,MRPS36, NDUFB5,NDUFS4,PCCB,SDHD,SNRNP27,SUCLG2,TMEM14B | ||||
ACN9,C14orf142,COA5,PRADC1,PTRHD1,TMEM261,CHMP5, DUSP11,HSCB,IFT20,KBTBD3,MCEE,NDUFA6,NDUFB5, NDUFB6,NIPSNAP3A,NUDT2,OST4,OSTC,PIGF,SAR1B | KANSL2,C12orf57,TIMMDC1,C6orf57,COG6,DPY30,ERLEC1, HAUS1,HSCB,INTS10,LYRM2,MCEE,NSMCE4A,RPL41, RPSAP58,SNRPD2,SSR2,TGDS,TMEM216,ZNF511,ZNHIT3 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for MCEE |
Cross-referenced pharmacological DB IDs from Uniprot |
DB Category | DB Name | DB's ID and Url link |
Drug-Gene Interaction Network |
* Gene Centered Interaction Network. |
* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB00121 | methylmalonyl CoA epimerase | approved; nutraceutical | Biotin |
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Cross referenced IDs for MCEE |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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