Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

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	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for TUBA1C

Basic gene info.	Gene symbol	TUBA1C
	Gene name	tubulin, alpha 1c
	Synonyms	TUBA6\|bcm948
	Cytomap	UCSC genome browser: 12q13.12
	Genomic location	chr12 :49658864-49667113
	Type of gene	protein-coding
	RefGenes	NM_001303114.1, NM_001303115.1,NM_001303116.1,NM_001303117.1,NM_032704.4,
	Ensembl id	ENSG00000167553
	Description	alpha-tubulin 6tubulin alpha-1C chaintubulin alpha-6 chaintubulin, alpha 6
	Modification date	20141218
dbXrefs	HGNC : HGNC
	Ensembl : ENSG00000167553
	HPRD : 06747
	Vega : OTTHUMG00000169497
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_TUBA1C
	BioGPS: 84790
	Gene Expression Atlas: ENSG00000167553
	The Human Protein Atlas: ENSG00000167553
Pathway	NCI Pathway Interaction Database: TUBA1C
	KEGG: TUBA1C
	REACTOME: TUBA1C
	ConsensusPathDB
	Pathway Commons: TUBA1C
Metabolism	MetaCyc: TUBA1C
	HUMANCyc: TUBA1C
Regulation	Ensembl's Regulation: ENSG00000167553
	miRBase: chr12 :49,658,864-49,667,113
	TargetScan: NM_001303114
	cisRED: ENSG00000167553
Context	iHOP: TUBA1C
	cancer metabolism search in PubMed: TUBA1C
	UCL Cancer Institute: TUBA1C
Assigned class in ccmGDB	C

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Phenotypic Information for TUBA1C(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: TUBA1C
	Familial Cancer Database: TUBA1C

* This gene is included in those cancer gene databases.

						.
Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in	Therapeutic Vulnerabilities in Cancer¹

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
REACTOME_METABOLISM_OF_PROTEINS

Others
OMIM
Orphanet
Disease	KEGG Disease: TUBA1C
	MedGen: TUBA1C (Human Medical Genetics with Condition)
	ClinVar: TUBA1C
Phenotype	MGI: TUBA1C (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: TUBA1C

Mutations for TUBA1C

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

There's no structural variation information in COSMIC data for this gene.

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows TUBA1C related fusion information.

ID	Head Gene						Tail Gene
Accession	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a
BM785206	TUBA1C	4	389	12	49658867	49663672	RPS23	383	455	5	81571883	81571955
CD368754	NCF2	18	335	1	183524697	183525014	TUBA1C	330	634	12	49666095	49666398
CD367941	TUBA1C	16	581	12	49666552	49667117	UBB	577	698	17	16285676	16285798
BE907310	TUBA1C	1	539	12	49666560	49667098	VPS39	539	742	15	42451247	42451456

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

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Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

There's no copy number variation information in COSMIC data for this gene.

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SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=2

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Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=30)	Stat. for Synonymous SNVs (# total SNVs=11)

Stat. for Deletions (# total SNVs=0)	Stat. for Insertions (# total SNVs=0)
There's no deleted snv.	There's no inserted snv.

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Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr12:49666312-49666312	p.D218N	2
chr12:49663751-49663751	p.R123C	2
chr12:49663397-49663397	p.T51T	2
chr12:49666563-49666563	p.Q301H	2
chr12:49666152-49666152	p.K164K	1
chr12:49666705-49666705	p.T349A	1
chr12:49666942-49666942	p.L428F	1
chr12:49663626-49663626	p.G81D	1
chr12:49666155-49666155	p.S165S	1
chr12:49666727-49666727	p.N356S	1

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SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample	1	2	1	5					2			3	3				2	3		5
# mutation	1	2	1	5					2			3	3				2	3		5
nonsynonymous SNV	1	2	1	4								2	1				1	3		5
synonymous SNV				1					2			1	2				1

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chr12:49666312	p.D218N	2
chr12:49666675	p.S165S	1
chr12:49666051	p.S170S	1
chr12:49666705	p.A174A	1
chr12:49666122	p.S198P	1
chr12:49666727	p.R2P	1
chr12:49666152	p.S277C	1
chr12:49666750	p.Q31L	1
chr12:49663249	p.T292A	1
chr12:49666155	p.V66V	1

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for TUBA1C in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for TUBA1C

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

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CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

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Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


AURKB,AUNIP,CCNB1,CCNB2,CDC20,CDCA3,CDCA8, CENPA,CENPN,CKS1B,KIF20A,KIF2C,PLK1,PSMB2, PTTG1,RAN,TPX2,TROAP,TUBA1B,TUBA1C,UBE2C	ACOT7,ACTB,ATP6V0B,R3HDM4,CFL1,CLIC1,DNAJB11, GNA15,HM13,HNRNPAB,MANF,PFN1,PPP4C,PRELID1, RHOC,TAGLN2,TUBA1A,TUBA1B,TUBA1C,TUBB4B,VASP

CCT2,COX6A1,DIABLO,EMG1,EPR1,HN1,MCRS1, MRPS12,NDUFA12,NME1,NUP37,PGAM5,PSMA5,PSMD9, PTGES3,RAN,SRSF9,SNRPF,TUBA1B,TUBA1C,UBE2N	AAGAB,AMD1,ANXA2,ANXA2P2,ARPC4,ATG4A,BZW1, C12orf49,C20orf24,CSTF2,F2RL1,NMNAT1,ORMDL2,RABIF, SERPINB1,SLMO2,TAGLN2,TPMT,TUBA1C,TUBB4B,UPP1

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

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Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for TUBA1C

Cross-referenced pharmacological DB IDs from Uniprot

DB Category

DB Name

DB's ID and Url link

Drug-Gene Interaction Network

* Gene Centered Interaction Network.

* Drug Centered Interaction Network.

DrugBank ID	Target Name	Drug Groups	Generic Name	Drug Centered Network	Drug Structure
DB01873	tubulin, alpha 1c	experimental; investigational	Epothilone D
DB03010	tubulin, alpha 1c	experimental; investigational	Epothilone B
DB07574	tubulin, alpha 1c	experimental	2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE

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Cross referenced IDs for TUBA1C

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information