|
Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for ALG2 |
Basic gene info. | Gene symbol | ALG2 |
Gene name | ALG2, alpha-1,3/1,6-mannosyltransferase | |
Synonyms | CDGIi|NET38|hALPG2 | |
Cytomap | UCSC genome browser: 9q22.33 | |
Genomic location | chr9 :101978706-101984246 | |
Type of gene | protein-coding | |
RefGenes | NM_033087.3, NR_024532.1,NM_197973.2, | |
Ensembl id | ENSG00000119523 | |
Description | GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferaseGDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferaseGDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferasealpha-1,3-mannosyltransferase ALG2alpha-1,3/1,6-mannosyltransferase ALG2asp | |
Modification date | 20141222 | |
dbXrefs | MIM : 607905 | |
HGNC : HGNC | ||
HPRD : 09716 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ALG2 | |
BioGPS: 85365 | ||
Gene Expression Atlas: ENSG00000119523 | ||
The Human Protein Atlas: ENSG00000119523 | ||
Pathway | NCI Pathway Interaction Database: ALG2 | |
KEGG: ALG2 | ||
REACTOME: ALG2 | ||
ConsensusPathDB | ||
Pathway Commons: ALG2 | ||
Metabolism | MetaCyc: ALG2 | |
HUMANCyc: ALG2 | ||
Regulation | Ensembl's Regulation: ENSG00000119523 | |
miRBase: chr9 :101,978,706-101,984,246 | ||
TargetScan: NM_033087 | ||
cisRED: ENSG00000119523 | ||
Context | iHOP: ALG2 | |
cancer metabolism search in PubMed: ALG2 | ||
UCL Cancer Institute: ALG2 | ||
Assigned class in ccmGDB | C |
Top |
Phenotypic Information for ALG2(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: ALG2 |
Familial Cancer Database: ALG2 |
* This gene is included in those cancer gene databases. |
. | ||||||||||||||||||||
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
REACTOME_METABOLISM_OF_PROTEINS |
Others | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: ALG2 |
MedGen: ALG2 (Human Medical Genetics with Condition) | |
ClinVar: ALG2 | |
Phenotype | MGI: ALG2 (International Mouse Phenotyping Consortium) |
PhenomicDB: ALG2 |
Mutations for ALG2 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
- Statistics for Tissue and Mutation type | Top |
- For Inter-chromosomal Variations |
There's no inter-chromosomal structural variation. |
- For Intra-chromosomal Variations |
There's no intra-chromosomal structural variation. |
Sample | Symbol_a | Chr_a | Start_a | End_a | Symbol_b | Chr_b | Start_b | End_b |
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract) |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ALG2 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
AI371982 | TNRC6C | 1 | 276 | 17 | 76100746 | 76101021 | ALG2 | 273 | 494 | 9 | 101980528 | 101980749 |
Other DBs for Structural Variants |
Top |
Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
There's no copy number variation information in COSMIC data for this gene. |
Top |
SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
|
Top |
Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=28) | (# total SNVs=6) |
(# total SNVs=0) | (# total SNVs=0) |
Top |
Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr9:101980889-101980889 | p.H193R | 4 |
chr9:101980562-101980562 | p.S302Y | 2 |
chr9:101980890-101980890 | p.H193Y | 2 |
chr9:101980430-101980430 | p.S346L | 1 |
chr9:101984055-101984055 | p.Q41P | 1 |
chr9:101980729-101980729 | p.A246A | 1 |
chr9:101980896-101980896 | p.L191L | 1 |
chr9:101980452-101980452 | p.C339R | 1 |
chr9:101984110-101984110 | p.D23Y | 1 |
chr9:101980740-101980740 | p.A243S | 1 |
Top |
SNV Counts per Each Loci in TCGA data |
|
Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 3 | 2 |   | 8 |   |   | 3 |   | 1 | 1 |   | 3 | 5 | 1 |   | 1 | 5 | 1 |   | 2 |
# mutation | 3 | 2 |   | 5 |   |   | 3 |   | 1 | 1 |   | 4 | 5 | 1 |   | 1 | 5 | 1 |   | 3 |
nonsynonymous SNV | 2 | 2 |   | 5 |   |   | 2 |   | 1 |   |   | 3 | 3 | 1 |   |   | 4 | 1 |   | 2 |
synonymous SNV | 1 |   |   |   |   |   | 1 |   |   | 1 |   | 1 | 2 |   |   | 1 | 1 |   |   | 1 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
Top |
Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr9:101980889 | p.H193R | 4 |
chr9:101980562 | p.S302Y | 2 |
chr9:101980890 | p.P366L | 2 |
chr9:101980370 | p.H193Y | 2 |
chr9:101980452 | p.F179Y | 1 |
chr9:101980791 | p.R301M | 1 |
chr9:101981079 | p.D171N | 1 |
chr9:101980476 | p.V297V | 1 |
chr9:101980827 | p.K132N | 1 |
chr9:101981082 | p.L284F | 1 |
Other DBs for Point Mutations |
Copy Number for ALG2 in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
Top |
Gene Expression for ALG2 |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
Top |
CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
Top |
Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
ALG2,C9orf156,FAM206A,DNAJB9,DNAJC25,ERP44,FAM120A, FAM120AOS,HIATL1,ISCA1,MRPL50,NAA35,PSMD5,RAB14, RAD23B,RNF103,RNF20,SEC61B,SPTLC1,STX17,ZNF189 | ADO,ADSS,ALG2,SMIM15,CISD2,DAZAP2,HPRT1, IQCK,LOC653566,MARCKS,MYCBP,NPTN,PERP,RAB14, SERP1,TMCO1,TMEM14A,TMEM33,TMEM9B,TP53RK,YWHAQ |
ALG2,ATP6V1G1,C9orf156,CAAP1,C9orf85,CHMP5,DNAJC25, DOLK,ERP44,FXN,ISCA1,ISCA1P1,MRPL50,NANS, POLE3,PSMD5,SEC61B,SERP1,SRPRB,SURF4,TEX10 | ADPGK,ALG2,VWA9,DCBLD1,ERLIN1,FAM136A,KIAA0391, MEST,MIOS,MRPS30,MRRF,PIGF,RFWD2,RINT1, SERP1,SHQ1,SLC30A5,SLC30A9,TMED5,UTP18,XBP1 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
Top |
Interacting Genes (from Pathway Commons) |
Top |
Pharmacological Information for ALG2 |
There's no related Drug. |
Top |
Cross referenced IDs for ALG2 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
Copyright © 2016-Present - The Univsersity of Texas Health Science Center at Houston @ |