Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for TNKS1BP1
Basic gene info.Gene symbolTNKS1BP1
Gene nametankyrase 1 binding protein 1, 182kDa
SynonymsTAB182
CytomapUCSC genome browser: 11q12.1
Genomic locationchr11 :57067102-57092413
Type of geneprotein-coding
RefGenesNM_033396.2,
Ensembl idENSG00000149115
Description182 kDa tankyrase-1-binding proteintankyrase 1-binding protein of 182 kDa
Modification date20141207
dbXrefs MIM : 607104
HGNC : HGNC
Ensembl : ENSG00000149115
HPRD : 06164
Vega : OTTHUMG00000167022
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_TNKS1BP1
BioGPS: 85456
Gene Expression Atlas: ENSG00000149115
The Human Protein Atlas: ENSG00000149115
PathwayNCI Pathway Interaction Database: TNKS1BP1
KEGG: TNKS1BP1
REACTOME: TNKS1BP1
ConsensusPathDB
Pathway Commons: TNKS1BP1
MetabolismMetaCyc: TNKS1BP1
HUMANCyc: TNKS1BP1
RegulationEnsembl's Regulation: ENSG00000149115
miRBase: chr11 :57,067,102-57,092,413
TargetScan: NM_033396
cisRED: ENSG00000149115
ContextiHOP: TNKS1BP1
cancer metabolism search in PubMed: TNKS1BP1
UCL Cancer Institute: TNKS1BP1
Assigned class in ccmGDBC

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Phenotypic Information for TNKS1BP1(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: TNKS1BP1
Familial Cancer Database: TNKS1BP1
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
REACTOME_METABOLISM_OF_MRNA
REACTOME_METABOLISM_OF_RNA

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: TNKS1BP1
MedGen: TNKS1BP1 (Human Medical Genetics with Condition)
ClinVar: TNKS1BP1
PhenotypeMGI: TNKS1BP1 (International Mouse Phenotyping Consortium)
PhenomicDB: TNKS1BP1

Mutations for TNKS1BP1
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram

- Statistics for Tissue and Mutation typeTop
- For Inter-chromosomal Variations
There's no inter-chromosomal structural variation.
- For Intra-chromosomal Variations
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'.
SampleSymbol_aChr_aStart_aEnd_aSymbol_bChr_bStart_bEnd_b
pancreasTNKS1BP1chr115707085757070877OR5AK2chr115675681356756833
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract)

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows TNKS1BP1 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
BF810602TNKS1BP12202115707716757077371MACF119836313980287239806207
BG436080TNKS1BP11106115708328957083394PSG3102672194340753843411312
BF812770ZNF20718156173070047030700610TNKS1BP1142380115707493857075174
BF844047FHL2821032106025408106025429TNKS1BP192356115706720757067473
BF950679NLGN35401X7039028070390675TNKS1BP1390583115707647857076671
BF838059ANKDD1A22122156521875765218859TNKS1BP1111216115706729757067402
BF756786IGFBP41248173861364038613889TNKS1BP1246402115707636057076516
AV704306TNKS1BP11499115707509457075591LRCH44966147100172283100172403
BM693293TNKS1BP11142115707502057075161XCR113420134606634046066411

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
 
Mutation type/ Tissue IDbrcacnscervendomehaematopokidnLintestliverlungnsovarypancreprostskinstomathyrourina
Total # sample   1             
GAIN (# sample)   1             
LOSS (# sample)                 
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=9

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=114)
Stat. for Synonymous SNVs
(# total SNVs=38)
Stat. for Deletions
(# total SNVs=7)
Stat. for Insertions
(# total SNVs=1)

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr11:57077353-57077353p.A944A7
chr11:57080736-57080736p.F476I3
chr11:57081197-57081197p.T322S3
chr11:57076529-57076529p.G1219fs*152
chr11:57080907-57080907p.R419C2
chr11:57069988-57069988p.R1543Q2
chr11:57089263-57089263p.?2
chr11:57087724-57087724p.R186H2
chr11:57076793-57076793p.R1131I2
chr11:57077118-57077119p.G1023fs*82

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample76 22  7 83 16103 12011115
# mutation76 26  7 83 17123 12513119
nonsynonymous SNV55 16  5 72 1393 11911 13
synonymous SNV21 10  2 11 43   6216
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr11:57077320p.T607T2
chr11:57080341p.R1131T2
chr11:57080351p.P604R2
chr11:57087724p.A898V2
chr11:57077492p.R186H2
chr11:57076793p.A972T2
chr11:57077271p.R959K2
chr11:57077309p.S955S2
chr11:57069596p.L818I1
chr11:57088123p.G1694R1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for TNKS1BP1 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for TNKS1BP1

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

AGRN,C11orf31,C9orf69,CCDC9,CLP1,EHD1,FAM73B,
INTS5,MAP3K11,MED19,OSBPL5,PBXIP1,PLCB3,PLXNB2,
RAB43,SIX5,TIMM10,TNKS1BP1,TSPAN9,ZBTB7B,ZDHHC5
AKT1,DDAH2,EGLN2,EML3,KIFC3,LRPAP1,MEGF8,
MUM1,OS9,PFKL,PLCB3,PPP1R12C,RAB35,SDF4,
SLC38A10,SLC4A2,SUN2,TAOK2,TMEM129,TNIP2,TNKS1BP1

AHDC1,AHNAK,AKAP13,ARHGAP1,CIC,GLG1,GOLGA2,
HSPG2,IL4R,KDM2A,KIAA0247,MKL1,MYH9,RAI1,
RAPGEF3,SH3PXD2A,SLC9A3R2,SUN2,TECPR1,TNKS1BP1,TRIM8
AGRN,ANKRD11,ANKRD52,BRD4,FBXL19,GTF3C1,KDM2A,
LARP1,MCM3AP,KMT2B___KMT2D,MUC4,PHRF1,SEC16A,SMARCA4,
SPEN,SRCAP,TAOK2,TNKS1BP1,TRIM56,TRRAP,VPS13D
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for TNKS1BP1


There's no related Drug.
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Cross referenced IDs for TNKS1BP1
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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