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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for AOC3 |
Basic gene info. | Gene symbol | AOC3 |
Gene name | amine oxidase, copper containing 3 | |
Synonyms | HPAO|SSAO|VAP-1|VAP1 | |
Cytomap | UCSC genome browser: 17q21 | |
Genomic location | chr17 :41003200-41010140 | |
Type of gene | protein-coding | |
RefGenes | NM_001277731.1, NM_001277732.1,NM_003734.3,NR_102422.1, | |
Ensembl id | ENSG00000131471 | |
Description | amine oxidase, copper containing 3 (vascular adhesion protein 1)copper amine oxidasemembrane primary amine oxidaseplacenta copper monamine oxidasesemicarbazide-sensitive amine oxidase | |
Modification date | 20141207 | |
dbXrefs | MIM : 603735 | |
HGNC : HGNC | ||
Ensembl : ENSG00000131471 | ||
HPRD : 04770 | ||
Vega : OTTHUMG00000180656 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_AOC3 | |
BioGPS: 8639 | ||
Gene Expression Atlas: ENSG00000131471 | ||
The Human Protein Atlas: ENSG00000131471 | ||
Pathway | NCI Pathway Interaction Database: AOC3 | |
KEGG: AOC3 | ||
REACTOME: AOC3 | ||
ConsensusPathDB | ||
Pathway Commons: AOC3 | ||
Metabolism | MetaCyc: AOC3 | |
HUMANCyc: AOC3 | ||
Regulation | Ensembl's Regulation: ENSG00000131471 | |
miRBase: chr17 :41,003,200-41,010,140 | ||
TargetScan: NM_001277731 | ||
cisRED: ENSG00000131471 | ||
Context | iHOP: AOC3 | |
cancer metabolism search in PubMed: AOC3 | ||
UCL Cancer Institute: AOC3 | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for AOC3(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: AOC3 |
Familial Cancer Database: AOC3 |
* This gene is included in those cancer gene databases. |
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM KEGG_TYROSINE_METABOLISM KEGG_PHENYLALANINE_METABOLISM KEGG_BETA_ALANINE_METABOLISM |
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OMIM | |
Orphanet | |
Disease | KEGG Disease: AOC3 |
MedGen: AOC3 (Human Medical Genetics with Condition) | |
ClinVar: AOC3 | |
Phenotype | MGI: AOC3 (International Mouse Phenotyping Consortium) |
PhenomicDB: AOC3 |
Mutations for AOC3 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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There's no structural variation information in COSMIC data for this gene. |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows AOC3 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
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There's no copy number variation information in COSMIC data for this gene. |
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Stat. for Non-Synonymous SNVs (# total SNVs=61) | (# total SNVs=26) |
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(# total SNVs=0) | (# total SNVs=0) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr17:41004707-41004707 | p.S449S | 2 |
chr17:41004823-41004823 | p.R488Q | 2 |
chr17:41004333-41004333 | p.V325F | 2 |
chr17:41003669-41003669 | p.L103L | 2 |
chr17:41004722-41004722 | p.G454G | 2 |
chr17:41004468-41004468 | p.A370T | 2 |
chr17:41004729-41004729 | p.E457K | 2 |
chr17:41004340-41004340 | p.G327E | 2 |
chr17:41004133-41004133 | p.R258H | 2 |
chr17:41004661-41004661 | p.Q434R | 2 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 1 | 4 |   | 17 | 2 |   | 5 |   | 1 |   |   | 11 | 6 | 1 |   |   | 17 | 8 |   | 9 |
# mutation | 1 | 4 |   | 16 | 2 |   | 5 |   | 1 |   |   | 11 | 6 | 1 |   |   | 17 | 9 |   | 10 |
nonsynonymous SNV | 1 | 2 |   | 8 | 1 |   | 5 |   | 1 |   |   | 8 | 4 | 1 |   |   | 7 | 6 |   | 8 |
synonymous SNV |   | 2 |   | 8 | 1 |   |   |   |   |   |   | 3 | 2 |   |   |   | 10 | 3 |   | 2 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr17:41004133 | p.S449S,AOC3 | 2 |
chr17:41004468 | p.A370T,AOC3 | 2 |
chr17:41004707 | p.G454G,AOC3 | 2 |
chr17:41003593 | p.R78Q,AOC3 | 2 |
chr17:41004563 | p.R258H,AOC3 | 2 |
chr17:41004722 | p.G401G,AOC3 | 2 |
chr17:41004004 | p.S523S,AOC3 | 1 |
chr17:41004728 | p.G155R,AOC3 | 1 |
chr17:41004371 | p.G116G,AOC3 | 1 |
chr17:41006556 | p.R269C,AOC3 | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for AOC3 |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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ADH1B,ADIPOQ,AOC3,AQP7,C14orf180,CIDEC,GLYAT, GPD1,HEPACAM,ITIH5,KCNIP2,KLB,LIPE,NPR1, PLIN1,PLIN4,RDH5,SLC19A3,TMEM132C,TNS1,VWF | ACO1,AOC3,FAM213A,DMGDH,EHD2,ESYT1,GPD1, GYG2,HEPACAM,HEPN1,HRASLS5,LIPE,MGLL,MRAS, PLIN1,RDH5,TNS1,TSPAN3,TUSC5,TYRO3,VKORC1L1 | ||||
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ACTA2,AOC3,ATP2B4,BOC,CALD1,CLIP3,CPXM2, FERMT2,FHL1,ITGA7,KANK2,MEIS1,MSRB3,MYL9, NEXN,PGR,RNF150,SPARCL1,TAGLN,TNS1,ZEB1 | ACTN1,AOC3,ATP2B4,BVES,CACNA1C,CACNA1H,CPXM2, DACT3,FLNA,ITGA1,ITGB3,KCNH2,LDB3,MPP2, NPTXR,PDLIM7,PYGM,SLC8A2,TACR2,VCL,ZFHX4 |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for AOC3 |
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DB Category | DB Name | DB's ID and Url link |
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* Gene Centered Interaction Network. |
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* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB00780 | amine oxidase, copper containing 3 | approved | Phenelzine | ![]() | ![]() |
DB01275 | amine oxidase, copper containing 3 | approved | Hydralazine | ![]() | ![]() |
DB04334 | amine oxidase, copper containing 3 | experimental | 6-hydroxydopa quinone | ![]() | ![]() |
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Cross referenced IDs for AOC3 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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